Sam Gattis

Big thank you to @BattlefieldLead and Colonel Kevin Farrell for an enriching workshop. Who knew long-ago decisions on the battlefield could have such relevance today? #leadershipmatters #oerthlings

Interesting: label recombinant E3s on Cys w/ maleimide + linker + target binder, electroporate into cells, see if degradation ensues. Complementary to covalent fragment screens. Eye-opener was that a tagged CRL adaptor (SKP1) also led to degradation. cell.com/cell-chemical-…

SCOOP: An insanely well-funded company called Altos Labs is going after "rejuvenation" technology. Yamanaka factors. Epigenetic clocks. CRISPR. Offering academics $1 million salaries and more. Investor rumor mill: Milner, Bezos, ARCH. Musk? technologyreview.com/2021/09/04/103…

Assessing target engagement using proteome-wide solvent shift assays biorxiv.org/cgi/content/sh… #bioRxiv