Ali ihsan OLUK retweetledi
Ali ihsan OLUK
15K posts

Ali ihsan OLUK
@KasosMete
iç hastalıkları uzmanı- medikal onkoloji
Ankara Katılım Mart 2022
626 Takip Edilen503 Takipçiler
Ali ihsan OLUK retweetledi

#ASCO2026
HER2CLIMB-05 delivers across every key subgroup.
Adding tucatinib to maintenance trastuzumab/pertuzumab significantly prolonged PFS in HER2+ metastatic breast cancer:
🧠 Brain metastases: 8.5 vs 4.2 months
🌸 HR+ disease: 25.0 vs 18.1 months
🚀 De novo metastatic disease: 28.9 vs 16.8 months
Consistent benefit across subgroups reinforces tucatinib as a compelling maintenance strategy after first-line THP.@OncBrothers @OncoAlert @Larvol




English
Ali ihsan OLUK retweetledi

Day 5 #ASCO26 highlights:
1. #HER2CLIMB05: Tucatinib maintenance in HER2 metastatic breast cancer
2. ADC in 1L mTNBC
3. #SERENA6: Camizestrant in HR+ Breast Ca
4. #VIKTORIA1: Gedatolisib in HR+ Breast Ca
5. #REDUSE: DeEscalation BMA
#OncTwitter @ASCO @OncoAlert
1/6🙏🏽

English
Ali ihsan OLUK retweetledi

🆙 #ASCO26 #LCSM Poster
🔥≥4-Year Long-Term Beneficiaries of ICIs in Advanced NSCLC
✅Lung cancer specific OS 97.8% at 6yr, 88.0% at 8yr
✅Late progression only 11.1%; all ≤5 lesions; 42% treated locally
✅68% of deaths ≥4yr were non-primary-lung cancer
🎙️ @M_Torasawa Dr. Yoshihiro Masui @HHorinouchi
🔢8561
🔗 asco.org/abstracts-pres…
@OncoAlert @Larvol @ASCO

English
Ali ihsan OLUK retweetledi

👁️ Giant Cell Arteritis Red Flags
🚨 New headache after age 50
🚨 Jaw claudication
🚨 Visual symptoms
🚨 Scalp tenderness
⚠️ Time is vision.
Permanent visual loss may be preventable with early recognition and treatment.
#GCA #Vasculitis #Rheumatology #MedTwitter #MedicalEducation @docakx @IhabFathiSulima

Aravind Palraj@Rheumat_Aravind
Giant Cell Arteritis: @IhabFathiSulima @DrAkhilX @CelestinoGutirr #MedTwitter
English
Ali ihsan OLUK retweetledi

15-year SOFT/TEXT update confirms what many of us already sensed in clinic:
Not every premenopausal HR+ breast cancer needs endocrine escalation.
But the youngest, highest-risk patients absolutely do. 🎯
🔹 Exemestane + OFS continued to reduce distant recurrence vs tamoxifen + OFS
🔹 Biggest absolute benefit seen in:
• Age <35
• Grade 3 disease
• HER2-negative tumors
• Prior chemotherapy cohorts
In women <35 years with HER2-negative disease:
15-year OS:
➡️ 82.5% with exemestane + OFS
➡️ 68.1% with tamoxifen alone
That is not a marginal difference.
The real message from SOFT/TEXT in 2026:
Risk-adapted endocrine therapy matters more than ever. 📈
#ASCO26 #bcsm #OncoTwitter @OncoAlert @myesmo @esmo_open @ASCO

English
Ali ihsan OLUK retweetledi
Ali ihsan OLUK retweetledi
Ali ihsan OLUK retweetledi
Ali ihsan OLUK retweetledi
Ali ihsan OLUK retweetledi
Ali ihsan OLUK retweetledi
Ali ihsan OLUK retweetledi
Ali ihsan OLUK retweetledi

#ASCO26
IRIS-A
Adjuvant cape + trastuzumab in stage IA HER2+ BC
80.2% had tumors ≤0.5 cm, Tmic:%56!!
87.2% were HR-negative
5-year iDFS: 97.9%!
Systemic therapy for tumors ≤0.5 cm remains a gray area. However, in selected high-risk patients, this may be a practical option that avoids IV chemotherapy.


Yakup Ergün@dr_yakupergun
#ASCO26 IRIS-A trial Adjuvant capecitabine + trastuzumab in stage IA HER2+ breast cancer. n=187 5-year iDFS: 97.9% Grade ≥3 AE: 2.7% ‼️80% of patients had tumors ≤0.5 cm. Patients enrolled in APT and ATEMPT were higher risk. This looks like a potential IV chemotherapy-free option for low-risk stage I disease. Full data will matter.
English
Ali ihsan OLUK retweetledi
Ali ihsan OLUK retweetledi
Ali ihsan OLUK retweetledi

#ASCO26
Evolving landscape of metastatic TNBC
From the presentation by Rita Nanda, MD.
Source: Hennessy et al., ASCO Educational Book, 2026.

English
Ali ihsan OLUK retweetledi
Ali ihsan OLUK retweetledi

LORIN delivers one of the most impressive neoadjuvant targeted therapy datasets seen in stage III NSCLC.
🔹 pCR: 47%
🔹 MPR: 81%
🔹 R0 resection: 97%
🔹 Overall nodal downstaging: 90%
Perhaps the most striking finding: 72% of cN3 patients converted to pN0 after just 12 weeks of neoadjuvant lorlatinib.
#ASCO26 #ALK
@OncoAlert @StephenVLiu @OncoReporte @MedwatchKate @christine_lovly @RManochakian @weoncologists



English
Ali ihsan OLUK retweetledi



































