Nature Chemical Biology

Our March issue is live! nature.com/nchembio/volum… The cover depicts the neuron as a plant with the nodules surround the roots representing condensates of SARM1, which lead to axonal fragmentation, illustrated as fractured roots

A new paper reports a high-throughput platform for quantifying the rare earth metal selectivity of lanmodulin proteins, enabling high-purity rare earth metal recovery and separations nature.com/articles/s4158…

Activation and regulation of the dynein-dynactin-NuMa complex in organizing microtubules in mitotic spindle assembly nature.com/articles/s4158…

A new paper reports that IDO1 regulates rhythmic oscillations of ROS dynamics, which are lost in hypoxic tumor cells. AhR mediates disordered ROS accumulation, and dual inhibition of IDO1 and AhR is shown to be a potential cancer therapeutic strategy nature.com/articles/s4158…

A new Comment discusses how an integrative cross-disciplinary research program in China aims to link RNA biology with traditional drug discovery to accelerate RNA innovation in RNA-centered therapeutics nature.com/articles/s4158…

Iterative catalysis in RiPP biosynthesis typically modifies linear peptides. Here, the authors discover GNAT enzymes that iteratively modify fully folded lasso peptides and engineer them to create lipolasso peptides with expanded chemical diversity nature.com/articles/s4158…

A deep redox proteomics study identifies redox-regulated and druggable cysteines in immune proteins nature.com/articles/s4158…

A CRISPR-based system records cell signaling activity as DNA edits readable by imaging nature.com/articles/s4158…

Chimerization expands peroxiredoxin scope – Check out the associated News & Views by Hortense Mazon, Benjamin Selles, and Sophie Rahuel-Clermont nature.com/articles/s4158…

Peroxiredoxins from diverse organisms are found to assemble into hybrid complexes, not just identical ones. These mixed assemblies reshape structure and stability, challenging a long-held view of peroxiredoxin assembly in cells nature.com/articles/s4158…

The three enzymes ALG3, ALG9, and ALG12 catalyze the synthesis of the branched mannose core in N-glycans in four distinct steps. Now, their structures reveal the molecular logic of oligomannose core assembly #glycotime nature.com/articles/s4158…

A new Perspective by Kate Carroll and Jing Yang provides a chemical framework of sulfur and the cysteine redoxome and discusses probe and proteomics workflow development and decoding the dynamic changes in the cysteine redoxome nature.com/articles/s4158…

The Front Half includes Research Highlights on natural product discovery, GPCR signaling, and protein design and a Review on degron and degradation signals promoting substrate-E3 ligase interactions

Our March issue is live! nature.com/nchembio/volum… The cover depicts the neuron as a plant with the nodules surround the roots representing condensates of SARM1, which lead to axonal fragmentation, illustrated as fractured roots

Mast cell extracellular granules are found to be condensates formed through sugar-metabolite interactions with elevated pH and higher metal concentration that enrich and enhance the activity of immune modulators, such as cytokines and proteases nature.com/articles/s4158…

A new Review discusses current research and future directions in protein persulfidation and polysulfidation to enable their full potential in redox-based therapeutic efforts nature.com/articles/s4158…

A chemigenetic DNA nanoprobe enables rapid and selective mapping of norepinephrine dynamics in organelles and is used to show that norepinephrine bursts in the ER trigger neuronal death during traumatic brain injury nature.com/articles/s4158…

Drug-controlled DROP-CARs enable reversible extracellular control of CAR T cell function via human-derived protein switches that modulate cell-cell interactions and support dual-antigen targeting as well as logic-gated signaling nature.com/articles/s4158…

Mechanosensitive PIEZO channels sense and open through membrane tension, but their dynamic gating mechanisms remain unclear. A multi-scale simulation approach and electrophysiology reveal a clockwork mechanism for PIEZO2 involving two open states nature.com/articles/s4158…

A high-throughput approach modifies existing ligands into molecular glue degraders nature.com/articles/s4158…

A new paper reveals that adhesion GPCRs promote extracellular vesicle (EV) formation and EVs spread GPCRs into neighboring cells to activate G-protein signaling, providing a novel mechanism for cell-cell communication nature.com/articles/s4158…