Neural Cell News

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The following review highlights cathepsins as emerging biomarkers and therapeutic targets in glioblastoma, summarizing current research and future directions for clinical application. 📖 bit.ly/48RPrZi

In this @NatureComms study, scientists develop a synthetic foldamer that stabilizes transient helical regions in Aβ, reducing aggregation and improving pathology in #Alzheimers disease models. 📝 go.nature.com/4tw4SOa

🔬 Researchers led by Dr. Luca Lo Piccolo identify a pyrazolopyridine alkaloid that reduces neuronal ER stress and improves age-related decline, highlighting a potential strategy for #neurodegenerative disease intervention. 🔖 go.nature.com/3Pbfiom

Scientists in the lab of Dr. Ilyas Singeç at @ncats_nih_gov have developed human iPSC-derived #CerebellarOrganoids that model cerebellar development and #FriedreichsAtaxia, enabling disease studies and therapeutic testing. 🧠 Read the study in @CommsBio: go.nature.com/4db5eDF

As brain cells age, they often make mistakes when processing their genetic instructions. This creates #RNAPollution, which accumulates over decades, making the brain highly vulnerable to neurodegenerative diseases. Researchers at @UCSDMedSchool, the @salkinstitute, and @sbpdiscovery have received a $13M award to investigate how to reverse age-related neurodegeneration by eliminating RNA pollution in aging neurons. 🧠 Learn more: bit.ly/4cYaAU9

Check out this new study from the lab of Dr. Dimitra Thomaidou! 👇 It shows that TET1 and LIN28A are key regulators that enhance miR-124/ISX9-driven astrocyte-to-neuron reprogramming and #NeuronalMaturation. Learn more: bit.ly/42cwgWl

A team of researchers at @UCSDMedSchool, @salkinstitute, and @sbpdiscovery have been funded to investigate how to reverse age-related #neurodegeneration by eliminating what the researchers call "RNA pollution" in aging neurons. The ultimate goal is to develop new therapies to protect against neurodegenerative diseases. 🧠 bit.ly/4cYaAU9

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Led by Drs. Donovan Pineau and Jean-Philippe Hugnot, researchers show that EDNRB-dependent endothelin signaling reduces glioma cell proliferation while driving proneural-to-mesenchymal transition and tumor plasticity. Learn more here: ▶️ bit.ly/3OSCAza

Modeling glioblastoma relapse in vitro! Scientists explore the spectrum of in vitro models from 2D cultures to organ-on-chip systems, to better study #glioblastoma relapse and therapy resistance. Learn more here: 📖 go.nature.com/42ECLBe

In search for new astrocyte-specific therapies! 🧠 Drs. Alexei Verkhratsky, C. Justin Lee, Agneta Nordberg, and colleagues review how #astrocyte dysfunction contributes to neurological diseases and explore astrocyte-specific therapeutic strategies. 🔖 go.nature.com/49gs7nW

Linking oxidative stress to neurodegeneration 🔍 Researchers show that oxidative stress drives astrocyte-derived collagen production, forming glial barriers that promote #neuronal death after stroke. ▶️ bit.ly/494agk7

Investigators at the @broadinstitute alongside Dr. Jen Pan investigate the functional consequences of XPO7 loss of function in hiPSC-derived #neurons, focusing on its role as a schizophrenia risk gene. 📗 go.nature.com/4uaW1Sy

🧠 Scientists suggest that MECP2-pS423 is a promising mechanism-based biomarker and potential therapeutic target because its accumulation correlates with pathological and cognitive deficits in the brain and serum of human sporadic Alzheimer’s disease. 🔗 bit.ly/4cxJqmE

🧫 Scientists demonstrated that FABP7 is essential for maintaining RG scaffold stability and proper neuronal positioning, and describe the convergent consistency of FABP7 deficiency with neurodevelopmental diseases. @PNASNews | bit.ly/4sJNUeH

Rasmus Rydbirk and investigators at @UniSouthDenmark performed single-nucleus RNA sequencing on postmortem striatal brain tissue from 7 MSA and 12 PD patients, and 10 non-neurological cases to elucidate the distinct cellular pathophysiology. @NatureComms | go.nature.com/48dJDZH

💡 Researchers suggest that neural circuits can undergo adaptive reshaping under conditions of synaptic reduction and may provide a foundation for editing synaptic architecture with therapeutic potential for connectopathies. @NatureComms | go.nature.com/41PzoHo

🧠 Investigators show that the dysfunction of CAR T cells in #glioblastoma is attributed, at least in part, to glucose deficiency in the tumor microenvironment driven by the substantial consumption of glucose by cancer cells. @ScienceTM | bit.ly/41KNhXq

Researchers at @UCLIoN alongside Dr. Giampietro Schiavo found that the neurotrophin brain-derived neurotrophic factor amplifies multiple neuron-intrinsic programs to foster axonal regeneration in human iPSC-derived lower motor neurons. 🔖 bit.ly/4cwq7Jf

Scientists at @Harvard alongside Dr. Victor M. Navarro highlight how neurokinin receptor antagonists target KNDy neuron signaling to treat menopausal hot flashes, offering a promising non-hormonal therapy. 📖 go.nature.com/4swY16t