PAIN Journal

We're extremely proud to announce #PAIN's 2025 supplemental issue: Advancing Pain Research and Management for the Next 50 Years. The entire issue is free to read on our website! bit.ly/3IQ6hOq

In this week’s #PAIN Featured Image, @fadelzeidan et al. demonstrate how mindfulness meditation significantly reduced state anxiety relative to control, but lower state anxiety was only marginally associated with lower pain intensity ratings #PAIN bit.ly/3NgFmxj

@LouiseKuhlmann et al. identify three chronic pancreatitis pain phenotypes using COMPAT-SF. Phenotypes differed in psychological burden, sensory function, and quality of life, supporting tailored treatment approaches. Learn more in #PAIN bit.ly/4b9vCgo

Glass et al. find no evidence that (V) low birth weight or preterm birth was associated with increased odds of caregiver-reported chronic pain in childhood or adolescence. Learn more in #PAIN bit.ly/4cuJYu3

Papic et al. find that chronic pain affects up to half of adults after moderate to severe TBI (about double the general population rates) with psychosocial factors and prior headache predicting risk. Evidence for effective treatments remains limited #PAIN bit.ly/4cP17ij

Morchio et al. demonstrate how transcriptomics of rare human neuromas reveals a novel role for endothelial cell dysfunction and HLA-A in neuropathic pain. Learn more in #PAIN bit.ly/4cx5Hl6

In this week’s #PAIN Featured Image, Cermak et al. depict increased perineuronal nets in the nucleus accumbens core and shell of a mouse model of neuropathic pain. Learn more at bit.ly/4cvRRPS

@DrFehlings et al. find that pain in patients with degenerative cervical myelopathy can be reduced by surgery; however, individuals can follow fundamentally different trajectories, including chronic postsurgical pain. Learn more in #PAIN bit.ly/4b9fjA3

@JemmaLTodd et al. find that fear of recurrence/progression is common in endometriosis and is linked to existential concerns, greater pain, and poorer well-being. Learn more in #PAIN bit.ly/3N5XXfi

Aulenkamp et al. find that visceral pain is highly susceptible to nocebo effects, which can arise or intensify through cross-modal transfer from adverse somatic experiences, underscoring relevance of provider communication. Learn more in #PAIN bit.ly/4b603nw

Ranathunga et al. find that small nerve fiber pathology is present in several non-neuropathic chronic pain conditions, though its clinical significance remains unclear. Learn more in #PAIN bit.ly/4b73HO5

This week’s #PAIN Featured Image is from @SutureHeadache et al. They found that noninvasive cranial suture stimulation can induce headache. Despite contradictive animal data, the effect appears unrelated to the stimulation sites with respect to the suture bit.ly/4cwiCDI

Zhang et al. find that intrathecal PF-05089771 produces potent, side-effect-free analgesia in mice, highlighting central Nav1.7 as a key target for effective pain relief. Learn more in #PAIN bit.ly/4b5TwJt

@ambinshtok et al. find that activating a single nociceptor terminal in vivo triggers the activation of a remote nonstimulated terminal of the same neuron. This efferent signaling increases during inflammation. Learn more in #PAIN bit.ly/3N7gJTx

@johnstreicher1 et al. find that inhibition of Heat shock protein 90 in the mouse spinal cord leads to enhanced Src kinase signaling in microglia, which further leads to enhanced opioid antinociception. Learn more in #PAIN bit.ly/4cZSXU8

Staedtler et al. highlight the key role of TRPV1 nociceptors in human tissue damage and neuropathic pain and discuss how molecularly distinct nociceptor subtypes may guide the development of new analgesic targets. Learn more in #PAIN bit.ly/3NbHJBk

In this week’s #PAIN Featured Image, @jon_enders et al. depict representative images of cultured wildtype and Fabry DRG neurons, and 2-way ANOVA, with a main effect of genotype: P < 0.005. Learn more at bit.ly/4qid6b6

Zeng et al. find that hydrogen-rich water alleviates neuropathic pain by modulating gut microbiota-related bile acid metabolites and activating TGR5 in the spinal cord, dorsal root ganglia, and colon, thereby promoting autophagy. Learn more in #PAIN bit.ly/3MMwaAJ

Ang et al. find that self-guided online cognitive behavioral therapy did not offer benefits beyond those of duloxetine monotherapy, highlighting the importance of compliance to the CBT program. Learn more in #PAIN bit.ly/3MJj4nO

Inflammatory profiles during acute low back pain diverge by sex and age. Brown et al. find that monocyte and lymphocyte differentiation predict chronic pain transition independent of age and sex. Learn more in #PAIN bit.ly/4rX22Sm

Hopkins et al. find that prescription opioid discontinuation was not associated with suicide death but was associated with reduced odds of fatal unintentional overdose in a set of Australian nested case-control studies. Learn more in #PAIN bit.ly/4qhZWLa