PRONTO Trial

PRONTO trial - procalcitonin in sepsis. Great to hear the confusing initial results. CRASH2 taught us the importance of planning a subgroup analysis based on underlying condition in EM trials - hopefully this will be in the PRONTO publication due early 2025. @Pronto_Trial

Will be with @LBrookesHowell today at #ICTMC2024 presenting some qualitative findings on the challenges of intervention adoption and challenges of recruitment and consent (RWPC) from @Pronto_Trial. @CTRCardiffUni @NIHRresearch @ResearchWales @ictmc2024

🏥 Sepsis can be tricky to diagnose: @Pronto_Trial is testing new methods to guide treatment faster and more effectively. Read about Julie's journey and how we’re fighting sepsis: blogs.cardiff.ac.uk/centre-for-tri… #WorldSepsisDay @ResearchWales @UKCTUNetwork

🌍 On #WorldSepsisDay, we highlight @Pronto_Trial's role in reducing sepsis deaths through timely antibiotics and reduced antibiotic resistance. Read Julie’s journey as a sepsis survivor here: blogs.cardiff.ac.uk/centre-for-tri… #WorldSepsisDay @ResearchWales @UKCTUNetwork @CUBLSResearch

Good morning! Analysis begins next week and site close down is due to commence. A couple of reminders: • Please pack your study tablets ready for collection. • Please ensure you send any remaining data queries back to our data manager (just a couple more left). Thank you!

This #InternationalWomensDay, @GlobalSepsis & @MedWomenIntl unite to fight #sepsis & enhance women's health globally. DYK? women face 26.2M sepsis cases yearly. Tag, share & like for #sepsisawareness worldsepsisday.org/news/2024/3/8/…

Great news but we’re still missing much needed information on utility of POC tests to enable targeted and ‘appropriate’ use of antibiotics at the front door. @Pronto_Trial is now in analysis phase and will report later this year.

It’s the end of #WAAW2023 & we’ve been highlighting work from our infections division at @CTRCardiffUni. #AMR & antimicrobial stewardship needs to be at forefront of our minds. We need better diagnostics, implemented quickly once evidence exists for better patient outcomes.

As part of #WAAW2023 let us congratulate our lead PPI rep Julie who completed the Conwy Half Marathon this weekend to raise awareness (and money) for the @UKSepsisTrust. Julie is a sepsis survivor and an inspiration to many. We work with Julie on other @CTRCardiffUni studies too!

Hurray! No prising open to steal the chocolates ahead of Dec 1st please! 🙃

🌍💊This #WAAW2023, learn how @CTRCardiffUni is contributing to research on antimicrobial resistance (AMR). Our World Antimicrobial Resistance Awareness Week blog: 🔗blogs.cardiff.ac.uk/centre-for-tri… @ResearchWales @UKCTUNetwork @Pronto_Trial @PEACH_Study1 @BATCH_trial @CarrolEnitan

@RaquelAkieme @EDRSCH @MartinLlewelyn More than deserved. We hope you enjoy 😊

You should all be receiving your Hotel Chocolat advent calendars now! Here are some more happy recipients, this time from @EDRSCH @RaquelAkieme @MartinLlewelyn Very well deserved guys! Now hold out until December 1st. (Permission received to share photo)

@Razorruddick You are more than welcome!

Lovely gift received today from @Pronto_Trial. Counting down the days until I can open it. Thank You so much 😋

We are busy planning a Christmas quiz for all involved iN PRONTO. Keep your eyes out for a Doodle poll of potential dates!

ANALYSIS TIMELINES —————————— Group 1 (May closure): Secondary outcome data queries due back Nov 17th. Group 2 (November Closure): Primary AND Secondary queries to be sent out Nov 17th. Due back by Christmas. Both Groups: all remaining general data queries to be sent in Jan.

So proud of our amazing team! Thank you our ED colleagues too who played a massive part in this huge achievement! They are engaged and supportive of research which is half the battle and without them we could not have achieved this. 💕💕

As we concentrate our efforts on data queries, another special mention goes to our lead site overall, Royal Liverpool University Hospital, @LivHospitals, who recruited a total of 1,256 patients into PRONTO! Wonderful effort from all. Thank you!

Each and every site has contributed to the amazing success of PRONTO but a special thanks goes to @UHDBTrust, our first site to open and who worked tirelessly throughout to recruit 1,511 patients (a smidge under 20 % of our target). Outstanding