Science Signaling

This week’s new issue of #ScienceSignaling is here! Scientists identify a redox switch in plants that fine-tunes the plant immune system’s response to infections, a team discovers metastatic functions for a protein long assumed to be inactive, and more. scim.ag/4bsifbg

How do plants balance immunity and growth? A team identifies a redox switch based on the transcription factor HAT1 that restrains immune responses in healthy #arabidopsis by sequestering TGA3 from NPR1, a process reversed during bacterial infection. @SCUCN scim.ag/4cTB6OG

“AI will not replace biological reasoning, but it may become indispensable for navigating biological systems whose complexity exceeds human intuition.” Read the new Focus that explores AI’s role in cancer #neuroscience: scim.ag/4djUTa9 @PancNeuropathy @TU_Muenchen

New work exploits #lncRNAs in the dark transcriptome that possess anti-inflammatory properties by reengineering them to dampen acute inflammation in mice—a finding that could open a new field of lncRNA-based therapies. @OFKLab @JanicePang_ @bme_uoft scim.ag/4urlDfg

A new variant of tracking and localization microscopy uses modified nanobodies and protein tags that periodically dissociate from target molecules to overcome photobleaching, thus extending tracking times from seconds to one hour. @UniOsnabrueck scim.ag/46Is9DX

How does STAT3 drive #CRC progression? A team shows that #glycolysis and the metabolite GlcNAc keep STAT3 in an abnormally activated state in CRC cells and that targeting glycolysis dampens STAT3 signaling and shrinks tumors in mice. @UMich scim.ag/4sq5SmU

In this week’s Editors’ Choice piece, we highlight a study by Zhang and colleagues in @CellCellPress, showing how sensory neurons convert cues from breast cancer cells into a barrier against anti-tumor immunity. Read a summary: scim.ag/4sHq6bS

"AI will not replace biological reasoning, but it may become indispensable for navigating biological systems whose complexity exceeds human intuition." A perspective on future applications for cancer neuroscience science.org/doi/10.1126/sc… @scisignal

The emergence of #AI tools is not only helpful in cancer #neuroscience, but may be needed to decode the highly complex networks that connect cancer cells to the nervous and immune systems, researchers argue in a new Focus. @PancNeuropathy @TU_Muenchen scim.ag/4djUTa9

A team presents the synthesis and chemical engineering of 3 #lncRNAs to suppress inflammation in mice and in human cells—one of the first demonstrations that lncRNAs outside of cells can be deployed to affect cell biology. @OFKLab @JanicePang_ @bme_uoft scim.ag/4urlDfg

The new issue of #ScienceSignaling is out! Scientists exploit the dark transcriptome to generate one of the first potential lncRNA therapies, a Focus discusses how AI is becoming a necessary tool to decode the mysteries of cancer neuroscience, and more. scim.ag/47vQVr9

A recent Review details the latest discoveries about how #metabolism changes in the aftermath of traumatic nerve injury—and explores how this metabolic landscape offers various targets for therapies to regenerate damaged axons. @N_Blab #NantongUniversity scim.ag/40yju3o

In this issue, a team of scientists devises a method to extend the time that individual molecules can be tracked in a cell, widening the analysis window from several seconds to more than an hour. @UniOsnabrueck #CellBiology scim.ag/46Is9DX

New work analyzes changes in protein abundance and phosphorylation that occur during the neuronal differentiation of KOLF2.IJ cells, providing data to assess changes during neurodevelopment and neurodegeneration in this promising cell line. @NIHAging scim.ag/4qTSdDd

Scientists show that the metabolite #acetate enhances the formation of long-term memories in female mice, revealing a previously unknown sex difference in the #epigenetic mechanisms that support memory formation. @eperiandri @WashUGenetics @GaborEgervari scim.ag/4aJU1c4

Researchers have shown how the metabolism of glucose drives #ColorectalCancer by activating a growth-fueling signaling pathway—and show that targeting this pathway can shrink tumors in mice. @UMich scim.ag/4sq5SmU #ColorectalCancerAwarenessMonth

Congrats to @UMPhysiology PhD Student Kathryn Buscher and collaborators in the @yatrikshahlab for her first author paper in @scisignal showing that glucose and downstream GlcNAC maintains STAT3 activation and contributes to colorectal cancer tumor growth.

A new variant of tracking and localization microscopy (TALM) uses modified nanobodies and protein tags that periodically dissociate from target molecules to overcome photobleaching, thus extending tracking times from seconds to one hour. @UniOsnabrueck scim.ag/46Is9DX

How does STAT3 drive #CRC progression? A team shows that #glycolysis and the metabolite GlcNAc keep STAT3 in an abnormally activated state in CRC cells and that targeting glycolysis dampens STAT3 signaling and shrinks tumors in mice. @UMich scim.ag/4sq5SmU

The new issue of #ScienceSignaling has arrived! A hyperactive signaling pathway presents a new target in colorectal cancer, a new imaging technique extends the tracking of single molecules from seconds to an hour, and more. scim.ag/3ONWyKY