Science Signaling

In a new study, scientists identify a series of molecular events that coordinates the widening of heart muscle cells in mice. @UPennPhysiology @Prosser_Lab scim.ag/4sLQeSo

How do #ostoeclasts fine-tune bone resorption despite being surrounded by Ca2+? New work in cells and mice shows that the membrane protein Tmem178 dampens the flow of Ca2+ into osteoclasts and restrains activation of the NLRP3 #inflammasome. @WashUMedBMD scim.ag/4cLX5VY

In this week’s Editors’ Choice piece, we highlight a study by Nagaraja and colleagues in @Nature, showing that colitis imposes epigenetic changes that prime colonic stem cells for tumor growth in mice. Read a summary: scim.ag/4sXsRpj

A deep dive into the #secretome reveals how peritoneal dialysis can trigger fibrosis and damage blood vessels, providing a resource that could inform efforts to limit toxicity from this lifesaving therapy. @klauskratochwi1 @RebeccaHerzog11 @MedUni_Wien scim.ag/3QBKLjV

The hormone CRH is produced outside of the brain in response to nerve damage and mediates a body-to-brain mechanism that sustains neuropathic pain, according to new work in mice that also shows CRH blockade alleviates pain sensitivity. scim.ag/4cDEeOj

Analyzing patient samples and a new cell culture workflow, scientists interrogate how #PeritonealDialysis fluid disrupts the secretome and how lithium chloride supplementation counteracts these side effects. @klauskratochwi1 @RebeccaHerzog11 @MedUni_Wien scim.ag/3QBKLjV

A deep dive into the secretome decrypts the origins of fibrotic side effects from peritoneal dialysis, a study in mice shows how blocking stress hormone signaling alleviates neuropathic pain, and more this week in #ScienceSignaling. scim.ag/4mWUz44

In a new srudy, scientists identify a series of molecular events that coordinates the widening of heart muscle cells in mice. @UPennPhysiology @Prosser_Lab scim.ag/4sLQeSo

How does high glucose impair cognition in diabetes? A team shows that high lactate from #glycolysis correlates with cognitive impairment in patients and that high glucose facilitates O-GlcNAcylation of Creb3 and leads to neurotoxic levels of lactate. scim.ag/4dQwdGI

New work sheds light on how the neurotrophic factor #BDNF critically supports the repair of motor neuron axons, yielding findings that may steer therapeutic development for motor neuron diseases, such as #ALS. @UCL_QS_CNMD scim.ag/3Q97mnK

How do #ostoeclasts fine-tune bone resorption despite being surrounded by Ca2+? New work in cells and mice shows that the membrane protein Tmem178 dampens the flow of Ca2+ into osteoclasts and restrains activation of the NLRP3 #inflammasome. @WashUMedBMD scim.ag/4cLX5VY

New work reveals how #phosphorylation of 4EBP1 by the kinase ERK at a previously uncharacterized site redistributes the accumulation of newly synthesized proteins to promote the concentric hypertrophy of #cardiomyocytes. @UPennPhysiology @Prosser_Lab scim.ag/4sLQeSo

Researchers have uncovered a pathway that keeps bone resorption in check by dampening the activation of #inflammasomes in osteoclasts—identifying an important restraint and helping to answer a paradox in the field of bone biology. @WashUMedBMD scim.ag/4sTa9Pv

This week’s new issue of #ScienceSignaling has arrived! A bone-protecting mechanism that restrains inflammasomes solves a paradox in osteoclast signaling, research identifies a pathway for expanding cardiomyocyte girth in mice, and more. scim.ag/3OCKRa9

New work sheds light on how the neurotrophic factor #BDNF critically supports the repair of motor neuron axons, yielding findings that may steer therapeutic development for motor neuron diseases, such as #ALS. @UCL_QS_CNMD scim.ag/3Q97mnK

Leveraging synthetic antibodies and single-molecule microscopy, scientists interrogate how #Wnt ligands may induce different downstream responses depending on which coreceptors are recruited to the Wnt receptor Frizzled. @StephAngers @uoftmedicine scim.ag/4e30J00

In a new Review, researchers discuss emerging paradigms in the study of brain #metastases, including the inner wiring of these tumors and potential therapeutic strategies to exploit their metabolic vulnerabilities. @sheilasinghlab @McMasterU scim.ag/3QwLHpq

An analysis of mice and more than 2000 patients reveals how high levels of glucose seen in #diabetes disrupt cognitive function by triggering the death of neurons in the hippocampus, a region in the brain involved in learning and memory. scim.ag/4dQwdGI

This week, a culture-based model of motor neuron regeneration reveals how BDNF regulates the array of pathways required for axon maintenance and repair, including the coordination of RNA stability and expression of injury-responsive genes. @UCL_QS_CNMD scim.ag/3Q97mnK

How does high glucose impair cognition in diabetes? A team shows that high lactate from #glycolysis correlates with cognitive impairment in patients and that high glucose facilitates O-GlcNAcylation of Creb3 and leads to neurotoxic levels of lactate. scim.ag/4dQwdGI