Science Signaling

An RNA-editing enzyme restrains the excessive proliferation of intestinal stem cells—a major hallmark of #aging in humans and other organisms—according to new work involving fruit flies and data from mice and human samples. @IHuaXi scim.ag/4x2MTkw

A signaling pathway involving the metabolite G3P and the protein complex #mTORC1 activates the production of triglycerides in the liver and may contribute to fatty liver disease, according to recent work in cells and mice. @uazmedphx scim.ag/44yeTQS

High expression of #NDRG1 in cancers supports DNA damage repair, according to new work that also reveals how mutations in other DNA repair genes can render tumors vulnerable to NDRG1-disrupting drugs such as quinacrine. @UCPH_Research @ScheibyeKnudsen scim.ag/4bWJ8F2

In this week’s Editors’ Choice, we highlight a study by He and colleagues in @Cell_Metabolism, showing how chronic stress in mice causes anxiety and hyperglycemia by inducing senescence in amygdala astrocytes. Read a summary: scim.ag/4wb5dY4

Using strategic chemical design, a team engineers an analog of the psychedelic #quipazine that targets 5-HT2AR but not 5-HT3R—preserving its antidepressant effects in mice, while minimizing off-target effects like nausea and vomiting. @jgmaeso @VCUPharmacy scim.ag/4vH1gtK

The RNA-editing enzyme ADAR works through an epigenetic and transcriptomic pathway to restrain proliferation of intestinal stem cells but declines with age and after gut injury, shows new work suggesting that ADAR acts as as a conserved safeguard. @IHuaXi scim.ag/4x2MTkw

Don’t miss this week’s new issue of #ScienceSignaling! Scientists trace how an RNA-editing enzyme restrains a hallmark of aging in intestinal stem cells, our Editors’ Choice piece considers recent findings about how stress induces senescence, and more. scim.ag/3RwR5dl

Scientists discover that high expression of the gene NDRG1 in various cancers supports DNA damage repair—a finding that could inform therapeutic efforts to take advantage of DNA damage and repair dependencies in cancer. @UCPH_Research @ScheibyeKnudsen scim.ag/4bWJ8F2

By studying cultured macrophages and a mouse model of #colitis, researchers have identified an enzyme that limits potentially damaging inflammatory responses by protecting cells from stress in the endoplasmic reticulum. scim.ag/4vCjInp

A signaling pathway involving the metabolite G3P and the protein complex #mTORC1 activates the production of triglycerides in the liver and may contribute to fatty liver disease, according to recent work in cells and mice. @uazmedphx scim.ag/44yeTQS

High expression of #NDRG1 in cancers supports DNA damage repair, according to new work that also reveals how mutations in other DNA repair genes can render tumors vulnerable to NDRG1-disrupting drugs such as quinacrine. @UCPH_Research @ScheibyeKnudsen scim.ag/4bWJ8F2

By leveraging strategic chemical design, researchers design an analog of the #psychedelic drug quipazine to produce fewer gastrointestinal side effects in mice, while maintaining its ability to alleviate depression-like behaviors. @jgmaeso @VCUPharmacy scim.ag/4vH1gtK

Using strategic chemical design, a team engineers an analog of the psychedelic #quipazine that targets 5-HT2AR but not 5-HT3R—preserving its antidepressant effects in mice, while minimizing off-target effects like nausea and vomiting. @jgmaeso @VCUPharmacy scim.ag/4vH1gtK

A redesigned psychedelic shows promising antidepressant-like effects in mice with fewer side effects, scientists discover a genetic marker of DNA damage vulnerability in cancer, and more in the new issue of #ScienceSignaling. scim.ag/4pytXro

By studying cultured macrophages and a mouse model of #colitis, researchers have identified an enzyme that limits potentially damaging inflammatory responses by protecting cells from stress in the endoplasmic reticulum. scim.ag/4vCjInp

A Review highlights recent advances that have uncovered how the Wnt and Hedgehog signaling pathways share many parallels and operate on a similar biochemical logic to perform a versatile array of roles. @huntsmancancer @Myers_lab scim.ag/4foCYzM

Leveraging real-time imaging, scientists show that interferon-γ from cytotoxic T cells directly kills melanoma cells that lack TBK1 and IKKε by inducing TNFR1 and ZPB1 and activating an inflammatory form of apoptosis via NF-κB signaling. @MayoClinic scim.ag/4bxqnYD

In this week’s Editors’ Choice piece, we highlight a study by Lu and colleagues in @Nature, showing that a molecular glue degrader tackles mutant BRAF in drug-resistant colorectal cancer by disrupting mRNA splicing. Read a summary: scim.ag/3RcuqTr

A signaling pathway involving the metabolite G3P and the protein complex #mTORC1 activates the production of triglycerides in the liver and may contribute to fatty liver disease, according to new work in cells and mice. @uazmedphx scim.ag/44yeTQS

The enzyme TRIM13 limits inflammatory responses in macrophages induced by TLR4 by targeting the calcium sensor STIM1 in the endoplasmic reticulum for degradation—and its loss exaerbates colitis in a mouse model. Learn more in new research: scim.ag/4vCjInp