SextonLab

Congrats to our own @jesse_wotring in his most recent publication: validating lactoferrin’s anti-SARS-CoV-2 activity! journalofdairyscience.org/article/S0022-…

@biorxivpreprint This project was not possible without the hard work and collaboration between @Charles_J_Zhang @momeara @CapelingMeghan @DayFerrerTorres @TheSpenceLab @RobertFontanaMD @jonnysexton and others

A Multi-Omics Human Liver Organoid Screening Platform for DILI Risk Prediction biorxiv.org/cgi/content/sh… #bioRxiv

Drug-induced liver injury has always been a burden on drug development, calling for better in vitro liver models. In this study, we combined a protocol for developing human liver organoids from iPSCs and a microfluidic “chip” system towards that goal.

US Study Shows 'Several Drug Contenders' Kill SARS-CoV2 Infection in Cells ibtimes.sg/A000FY4?utm_so…

@jesse_wotring @Charles_J_Zhang @MedChemMcCarty @tristanfrum @teresa_omeara

We are happy to announce our SARS-CoV-2 drug repurposing screen has just been published in PNAS! This was a massive team effort that would not be possible without many, including @ChristianeWobus @TheSpenceLab @ArulChinnaiyan @momeara pnas.org/content/118/36…

Exciting to share our work from a strong collaboration! Such great work by @DayFerrerTorres that we are thankful to be a part of.

Congrats to our three grad students, @Charles_J_Zhang, @MedChemMcCarty, and @jesse_wotring for flawlessly advancing into candidacy! Big things to come!

As #COVID19 manifests differently in different tissues we study their effects on a wide variety of cell lines. Cardiomyocytes are particularly interesting because you can watch them beat! Great work from Carla, @psychsiren!

Needed a physiological lung model, so I made one in an “organ-on-chip” system grown with @tristanfrum’s airway basal cells. Air flow and stretch applied to mimic breathing results in mucosal and ciliated cells. Hope to validate this for #COVID19 and other diseases! @SextonLabUM

@jesse_wotring @SextonLabUM Thank you for doing this important research, and we're thrilled to be a part of it!

@CaymanChemical Always making research possible! We used your FDA approved compound library to find drugs that can help fight SARS-CoV-2! Thank you for your help from a former Cayman Chemical intern under Holly Pierzynski and Nathan Layle! @SextonLabUM biorxiv.org/content/10.110…

@momeara gives a great breakdown here of our results!

We identify 15 FDA approved drugs and lactoferrin with possibility of treating SARS-CoV-2.

Our Covid19 drug repurposing screen found 15 FDA-approved drugs and the dietary supplement Lactoferrin have strong antiviral effects in vitro: biorxiv.org/content/10.110…

Tune in to this recent Michigan Minds podcast, where Jonathan Sexton describes our ongoing project in addressing COVID-19. publicengagement.umich.edu/michigan-minds…

ShoutOut to UM Center for Drug Repurposing in Scientific American's new article on drug repurposing: scientificamerican.com/article/old-dr…

Check out our collaborative study with Dr. Rishel Vohnoutka where we used @CellProfiler to quantitate cytoskeletal structure using radial distribution of intensities! On cover of MBoC - molbiolcell.org/doi/10.1091/mb…

@jonnysexton introducing the new MICHR Drug Repurposing center, designed to find new usage in old drugs! umdrugrepurposing.org

Hello world! Tomorrow marks the beginning of U of M Drug Repurposing. Please join us at our Town Hall where we will be introducing our services. Details: drugrepurposingtownhall.splashthat.com