The Ott Lab

Interested in learning more about our lab? We have a shiny, new, up-to-date website where you can see everything that we're currently working on. Check it out! ottlab.gladstone.org

Melanie Ott and Nadia Roan are central to a groundbreaking effort to create the world’s first map of how HIV affects the immune system at a single-cell level. @TheOttLab @amfAR bit.ly/4cgJOoh

In our new work published in @natBME in collaboration with @TheOttLab and @Doudna_lab, we introduce "interfering" guide RNAs (igRNAs) for CRISPR-Cas13a that regulate enzyme activity after activation. Congratulations to all the authors! nature.com/articles/s4155…

We honor the life of J. Michael Bishop, whose groundbreaking discoveries helped transform our understanding of cancer and opened new paths for treatment. His legacy will continue to inspire generations of scientists and clinicians. Rest in peace.

From chronic treatment to true cure: Melanie Ott (@TheOttLab) makes the case that controlling HIV isn’t the finish line—it’s just the beginning. Read more: bit.ly/4rWC8hx

Once a godsend, antiretroviral therapy is not what we should settle on. The time has come to finally cure HIV/AIDS. Read more in this commentary from Melanie Ott (@TheOttLab) bit.ly/4rWC8hx

Excited about a future in STEM? Applications are open for Gladstone’s 2026 PUMAS Summer Internship Program! PUMAS is a unique opportunity for community college students to gain real-world experience in biomedical research. Learn more on our website ➡️ bit.ly/2UVIaST

Tune in for our event on TikTok LIVE: “HIV Cure Lab Tour + Q&A"! 📆 Monday, December 1, 2025 at 10am PT 📍 Live on TikTok via @RaifDerrazi 🔗 Register: tiktok.com/live/event/757…

🚨 PUBLICATION🚨 "HIV-Induced T Cell Quiescence and the Origins of Viral Latency" in @NatImmunol From the @TheOttLab nature.com/articles/s4159…

Virologists need to reclaim the gain of function debate from politicians and set up streamlined international guidelines to work on viruses with pandemic potential. Read more in this @Nature opinion piece by @TheOttLab, @Virus_Immunity, and myself: nature.com/articles/d4158…

The Gladstone Institute of Virology has taken on a new name: the Gladstone Infectious Disease Institute. Check it out here: gladstone.org/news/beyond-vi…

Check out Dr. Melanie Ott's recent opinion piece on the SF Standard: sfstandard.com/opinion/2025/0…

Congrats Fran!

Thank you for supporting the next wave of HIV researchers. Because of you, amfAR’s 2025 Mathilde Krim Fellows are advancing bold ideas that bring us closer to a cure. Hear why your support matters.

Congratulations to Julia Prigann for being awarded the 2025 CFAR Excellence in Basic/Translational Science Award! cfar.ucsf.edu/user/11703

We are delighted that we could help with this work. Check it out here: authors.elsevier.com/c/1lEffL7PXuF0y

Scientists from Gladstone and @UCSF have developed drug candidates that could prevent future coronavirus pandemics. Read more about this recent study: bit.ly/4cHKGSC @ucsfpharmacy @UCSFMedicine @ScienceAdvances @TheOttLab @KroganLab @QBI_UCSF

Scientists from Gladstone and @UCSF has developed new antiviral drug candidates that show great promise against SARS-CoV-2, the virus that causes COVID-19, and may also be effective against other coronaviruses. Read more: bit.ly/4cHKGSC

🚨 NEW PUBLICATION 🚨 "Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy" @UCSF @ucsfpharmacy @UCSFMedicine @ScienceAdvances @TheOttLab @KroganLab @QBI_UCSF science.org/doi/10.1126/sc…

Scientists develop powerful drug candidates that could head off future coronavirus pandemics. @UCSF @ucsfpharmacy @UCSFMedicine @ScienceAdvances @TheOttLab @KroganLab @QBI_UCSF bit.ly/4cHKGSC

Why are measles cases surging? Paul Duprex @PittTweet on the origins; @TheOttLab @GladstoneInst on measles making us sick; @ajpollard1d @UniofOxford on the #MMR #vaccine and herd immunity; and Sander van der Linden @Cambridge_Uni on misinformation. thenakedscientists.com/podcasts/naked…