Usman Tahir

🧬Thanks @jclinicalinvest for highlighting our work integrating #genetics, proteomics and #EHR jci.org/articles/view/… in the editorial: “The importance of diverse multiomic datasets and analyses” #B6" target="_blank" rel="nofollow noopener">jci.org/articles/view/… *But why is diversity so important in #omics?* (1/n)

A packed audience for a personal live VO₂max test with real-time data walk-through by @JeffHsuMD & @BradleyPetek Did this last year and it was so much fun we had to do it again this year. Thanks to everyone who attended and @kerizozo for the invite!

In this #JACCBTS article, @UTahirMD, et al. use proteomics to identify SECTM1 protein levels and genetic variants associated with incident coronary heart disease and circulating monocyte levels. jacc.org/doi/10.1016/j.… #ASCVD @AartiAsnaniMD

It was wonderful hosting @MasriAhmadMD this past week for @BidmcCvi Grand Rounds. A masterful talk on the era of cardiac myosin inhibitors in HCM. Amazing progress in translating sarcomere biology to therapy for patients. but lots to do, especially for non-obstructive HCM.

🫀✨ New insights into Non-Dilated LV Cardiomyopathy! A large multicentre study shows that NDLVC is a dynamic disease, with nearly 40% of patients developing adverse LV remodeling over time 📉 🔍 Key predictors of progression: 🧬 Genetic + inflammatory aetiology ⚡ NSVT and conduction abnormalities 🧲 Ring-like LGE on CMR 📉 Baseline LVEF <45% 👨‍👩‍👧 Family history of CMP or sudden cardiac death 🛡️ Negative genetic testing stands out as the strongest protective factor. 📌 Take-home message: deep phenotyping + genetics are essential to identify high-risk patients early and guide personalised follow-up and management. #NDLVC #Cardiomyopathy #InheritedHeartDisease #CardioGenetics #CMR #Arrhythmias #HeartFailure #PrecisionCardiology #ESCguidelines 🧠🫀 doi.org/10.1016/j.cjca…

Viewpoint calls for improved training in genetics & genomics for cardiovascular clinicians to better translate advances academic.oup.com/eurheartj/arti… @ESC_Journals

Aficamten is now approved by the US FDA #CardioTwitter ir.cytokinetics.com/press-releases…

Using data from 5 cohorts and 2 proteomic platforms, we mapped out a comprehensive view of protein changes associated with CHIP🧬and examined causality using human👨‍🦱👩‍🦰& mice🐭🐭data Many thanks to all co-authors, with special gratitude to Dr. Libby @Dr_RajatGupta @pnatarajanmd !

BOLD INVITATION👇 "We have studied vulnerability long enough. Now we must also study protection. Somewhere inside biology of those who stay healthy, despite yrs of exposure, lies future of prevention Because in the end: Risk matters. Resilience decides. It is time we study both"

Proud of Cardiogenetics counselor @caitlin_finnn as she presents on Sudden cardiac arrest @ National Society of GC conference. Caitlin is an instrumental part of our Genetics program @BidmcCvi @DrPRao and a strong advocate for our genetics patients and their families.

6 patients dosed with single infusion of TN-01 via AAV vector to deliver functional copy of MYBPC3. Positive signals with reductions in hypertrophy, well tolerated, reversible liver enzyme ⬆️. Long term f/u ongoing.

Incredible moment at the #AHA25 with the first human to receive gene therapy for MYBPC3 HCM in the My-PEAK-1 trial sharing her desire to break the cycle of heart failure, cardiac transplant and SCD in her family. Interim results ⬇️

Link to article: jacc.org/doi/abs/10.101… Thanks to all mentors, contributors and cohort participants of JHS and Cardiovascular Health Study Rob Gerszten @AartiAsnaniMD @SwirskiLab

A nice editorial by @MariosGeorgakis highlights the utility of the multi-omics approach to new biology. As noted, we did not find genetic direct genetic evidence for SECTM1 --> CHD, highlighting the need for studies to work out the potential CHD pathways.jacc.org/doi/10.1016/j.…

🚨Excited to share our new study out in @JACCJournals Basic to Translational Science, where we integrate proteomics, genetics and in-vivo functional studies to identify SECTM1 as a novel regular of circulating monocyte levels associated with coronary heart disease 🧵

Really enjoyed joining @GenomeBC on the Nice Genes podcast🎙️ We talked about why some young athletes collapse mid-game, the genetics behind sudden cardiac arrest, and how our clinic @BidmcCvi bridges sports cardiology + genetics to keep athletes safely doing what they love. 🎧 link.cohostpodcasting.com/42490053-5a00-…