Prashant Bhat

261 posts

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Prashant Bhat

Prashant Bhat

@_prashantbhat

Uncovering the functions of genome organization | M.D. @UCLA👨🏽‍⚕️| Ph.D. '23 @mitchguttman @Caltech | Previously worked on #CRISPR @doudna_lab @UCBerkeley '14

Pasadena and Los Angeles, CA Katılım Kasım 2017
752 Takip Edilen893 Takipçiler
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Prashant Bhat
Prashant Bhat@_prashantbhat·
A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread! nature.com/articles/s4158…
Mitch Guttman@mitchguttman

What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez

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Stirling Churchman
Stirling Churchman@fiddle·
@_prashantbhat @openclaw It is! I run the Mac Mini headless so it's always on and has a small footprint. I got just the basic model (M4) because I'm not running AI models locally. I'm using @OpenAI models for now.
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Stirling Churchman
Stirling Churchman@fiddle·
It was my birthday a couple of weeks ago so I bought myself a Mac mini and installed @openclaw Meet Tessera! If you’re wondering what a “normie” genetics professor is doing with it or want tips to get started, ask 👇 !
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Mitch Guttman
Mitch Guttman@mitchguttman·
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…
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brangwynnelab
brangwynnelab@brangwynnelab·
Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors nature.com/articles/s4158…
Sofi Quinodoz@sofiquinodoz

Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…

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Yodai Takei
Yodai Takei@yodai_takei·
Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…
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Prashant Bhat
Prashant Bhat@_prashantbhat·
@shae_mcl Cool! Can’t wait to dive in. Does filtering for genomic regions by expression influence the predictions?
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Shae McLaughlin
Shae McLaughlin@shae_mcl·
A small slice of what I've been working on 🙂 Getting transformers to learn sequence determinants of genome architecture—we pre-trained a decoder-only model on eukaryote genomes and fine-tuned on nuclear lamina and nuclear speckle association. biorxiv.org/content/10.110…
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Mitch Guttman
Mitch Guttman@mitchguttman·
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in @NatureGenet describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. nature.com/articles/s4158…
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Ayush Noori
Ayush Noori@ayushnoori·
We’re excited to host @_prashantbhat from @uclacaltechmstp at the @HarvardDBMI Trainee Seminar Series (TSS) in the first week of December. Please see RSVP link below and feel free to reach out if any questions. 👇🏽
Prashant Bhat@_prashantbhat

Hi! I’ll be speaking at @harvardmed Department of Biomedical Informatics on December 5th about genome organization and splicing/speckles. Thank you to the organizers for the invite! Harvard/MIT/affiliate trainees can RSVP to attend with this link: forms.gle/LopwGCc8RbuCqS…

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Prashant Bhat
Prashant Bhat@_prashantbhat·
Hi! I’ll be speaking at @harvardmed Department of Biomedical Informatics on December 5th about genome organization and splicing/speckles. Thank you to the organizers for the invite! Harvard/MIT/affiliate trainees can RSVP to attend with this link: forms.gle/LopwGCc8RbuCqS…
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Levi Palmer
Levi Palmer@inelasticlevi·
@doescience This month has been a whirlwind 🌪️ of both amazing and terrible emotions for me ... BUT I'm happy to share our new preprint on an #EELS thermometry technique we're developing :,) arxiv.org/abs/2411.01071
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Ben Sabari
Ben Sabari@bsabari·
I am excited to share our review, published online today @NatRevMCB. Pilong Li, Gaofeng Pei, @Heankel_, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1). nature.com/articles/s4158…
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Prashant Bhat
Prashant Bhat@_prashantbhat·
And a big and hearty congratulations to Gary Ruvkun, too!
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Prashant Bhat
Prashant Bhat@_prashantbhat·
1st yr college (4/2011) Dr. Ambros visited Berkeley. His Cell 1993 paper was the 1st biology paper I ever read. After the talk, I asked for a picture; he looked around him when the organizer clarified, "Victor, he is asking to take a picture *with* YOU!" 🥲 Congrats, Victor!🧬
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Keşfet

@fiddle @openclaw @OpenAI @inelasticlevi @ACSPublications @CellCellPress @sofiquinodoz @jiang_lifei