Bristol Platelet Group

Thank you to all the attendees of the #EUPLAN2023 and @plateletsociety joint meeting for making this an amazing conference in Bristol. We look forward to the 2024 @plateletsociety meeting and then Würzburg @bender_lab for the 7th EUPLAN conference in 2025. @BristolPlatelet

Highlights of the Bristol Heart Festival

Come down and join us at the ‘Bristol Heart Festival’ in Wills Memorial Building today! ♥️ The Bristol platelet group are running three stalls ranging from being able to see clots up close to making your own smoothie through exercise! Open to the wider public from 4-7pm!

Happy International Women’s day from the Bristol platelet group! We are so proud and lucky to do great science with a fabulous team of superb women and have a wonderful team/lab who support them! #InternationalWomensDay2025

With the #internationaldayforwomenandgirlsinscience happening yesterday! We wanted to highlight the women in the Bristol Platelet Lab for their great scientific ethics and passion for platelet research #platelets #WomenInScience 🥼🧪

Merry Christmas from the Bristol Platelet Group! 🎄🎅🎄

Back in September some of the Bristol Platelet Group attended the ‘Advanced Course in Platelet Research’ held in Murcia. This was a great experience to hear about the cutting edge platelet research taking place at the moment. We also had a lot of fun in the sunny city too!

1.3 Focus points 💭 - Identification of platelet Rals as novel, potentially critical regulators of venous thrombus stability. - This happens through their ability to regulate neutrophil NET formation via platelet P-selectin. Read more: doi.org/10.1016/j.jtha…

Read it here: doi.org/10.1016/j.jtha… 📖📚

New Bristol Platelet Group paper: Critical role for platelet Ral GTPases in regulating venous thrombosis in mice’ by @yl4683, @JAFurniss12, Jordan Vautrinot, Christopher M Williams, Tony G Walsh, Alexander Brill, Dr Borko Amulic @Bristolneutlab and @alastair_poole Focus points👇

Focus points 💭 - Discussing how platelets are prime targets for PROTAC degradation.   - PROTACs can serve as research tools and therapeutic potential.   - Future studies should focus on enhancing cell specificity to avoid on-target side effects on.

New Bristol Platelet Group publication of our latest review: ‘PROTACs in Platelets: emerging antithrombotic strategies and future perspectives’ by @Justin_BPG Jordan Vautrinot, @CarlJamesMay and @HersIngeborg Read it here: doi.org/10.1097/moh.00… See below👇 for focus points!

📣Know the Signs of DVT! Thrombosis occurs when a blood clot forms in a vein or artery. Recognizing these signs early can be crucial in preventing serious complications. Stay informed, #KnowThrombosis and protect your health!

In this 11th year of #WorldThrombosisDay, the focus is on women and thrombosis 🙋‍♀️ Pregnancy and hormonal therapy elevate the risk of thrombosis. Awareness of healthcare professionals and patient empowerment can reduce the burden of this disease and save lives! #WTDay24 @thrombosisday 📖Read the latest editorial by @LanaCastellucci and @Lou_M_StGermain jthjournal.org/article/S1538-…

Today is World Thrombosis Day! -raising awareness about signs, prevention and treatment of thrombosis. @thrombosisday #WTDay24 👇👇 worldthrombosisday.org/know-thrombosi…

2:2 Focus points include: 🩸 Discussion of the different, hypothesised platelet production mechanisms in vivo 🩸 Comparing the platelet producing efficiency of published in vitro and ex vivo systems 🩸 Raising challenges and controversies in the field

1:2 New Bristol Platelet Group publication of our latest review: ‘Platelet Generation In Vivo and In Vitro’ by @JonathanFurniss, Nathalie Tarassova and @alastair_poole. Read it in Blood doi.org/10.1182/blood.… See thread👇 for focus points!

Thank you to everyone who was involved in the making of this paper and for all their hard work including @HersIngeborg @VarinderAggar11 @RobinCorey1 @Justin_BPG and others!

Congratulations to @Megan_F_Allen and co-authors on our recent publication in @BrJPharmacol exploring Difluorinated thromboxane A2 revealing crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors! doi.org/10.1111/bph.16… 🎉🥼

Congratulations to @HettyWalker2 for winning the best presentation prize at the @UoBPPN postgraduate away day. 🎉 Exciting work on design and application of FAK PROTACs in human platelets. @Tocris #TPD @HersIngeborg @VarinderAggar11

Great talk by our own Dr Yong Li presenting his work at #ISTH2024 in Bangkok on platelet releasate attenuating ischemic damage in acute myocardial infarction in mice. @alastair_poole @Timchico @HersIngeborg Cedric Ghevaert.