Caterina Conte

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@BevTchangMD @KevinH_PhD Agree on the confusion around FFM/LBM. 39% was calculated from Table S5. The % of total weight loss as lean mass is LM loss/(FM loss + LM loss), as for tirze. For brevity we used FFM in the Fig, including both LBM and FFM. The legend clarifies it’s LBM or FFM. Retatrutide is FFM.

I’m genuinely trying to get these numbers straight for myself since I think there is general confusion around FFM and LBM and I want to make sure I have it straight before educating others. Was your 39% calculated from wilding’s Table S5 and if so, what did you use as your denominator?

I've been staring at this for awhile and need clarification... @KevinH_PhD @CatConte_MD jamanetwork.com/journals/jama/… Are the tirzepatide numbers fat-free mass or are they lean soft tissue mass? I think the semaglutide (STEP1) is fat-free mass and the tirzepatide (SURMOUNT1) is lean soft tissue mass... pubmed.ncbi.nlm.nih.gov/39996356/

@BevTchangMD @KevinH_PhD Wilding: total LBM typically refers to the sum of LM in limbs, trunk, and head, excluding bone. Look: the reported FM loss (15.9kg) & LM loss (5.6kg) sum to 21.5kg, which aligns with a 21.3% WL from a baseline of 101.3kg (21.57kg). The 0.07kg gap is likely due to rounding

Look’s article reports lean mass (FFM-BMC) while Wilding’s supplement reported fat free mass. Calculations from their articles matches yours. But separately, Look’s fat mass loss (15.9 kg) plus lean mass loss (5.6 kg) adds up to 21.5 kg even though they reported total weight loss to be 21.3% (with baseline weight 100 kg). Is the 0.2 a rounding difference?

🇮🇹 La cura dell’obesità conta. Sei un* docente, tutor o specializzand* in Medicina Interna? 👩🏻‍🏫🧑🏾‍⚕️ Aiutaci a valutare la preparazione dei giovani internisti. Compila il questionario @EFIM_EU ➡️ urlsand.esvalabs.com/?u=https%3A%2F… #obesità #medicinainterna #giovaniinternisti @SIMI_MedInt

🇬🇧Obesity care matters. Are you an Internal Medicine educator, teaching physician, or resident? 👩🏻‍🏫🧑🏾‍⚕️ Help us assess young internists’ readiness to manage obesity. Take the @EFIM_EU survey ➡️ urlsand.esvalabs.com/?u=https%3A%2F… #obesity #internalmedicine #younginternists #obesitycare

📣Applications open! @Sid_Italia is accepting entries for the International Perugia Diabetes Award 2025!🏆 In honour of Francesca Diana, a €5,000 prize for excellence in #hypoglycaemia research will be awarded at the SID Panorama Diabetes Congress. More details & how to apply👇

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🎗️RISPETTO Usare un linguaggio “people-first” è importante. Parliamo di “persone con obesità”, non di “obesi”. Le persone non sono la loro malattia. La lotta allo #stigma comincia dalle parole #EndWeightStigma

🩺 UN INVITO ALLA PRECISIONE Chiarezza e accuratezza sono essenziali per evitare usi impropri o diffidenza nei confronti di trattamenti che potrebbero essere di grande beneficio

Nella puntata di @RaiPortaaPorta del 23/10 sono stati discussi temi legati all’obesità e ai farmaci per il suo trattamento. Condivido alcuni punti chiave per comprendere meglio #obesità #semaglutide #tirzepatide #informazione

Il 14 e 15 novembre 2024 si terrà il Congresso SIMI Sezione Puglia Basilicata 📍Auditorium della Camera di Commercio di Foggia, Via Michele Protano 7, Foggia 🖋️Iscrizioni congressi.simi.it/c/SIMI-Puglia-… Il 14/11 (9.30-12.30) si terrà il Corso Precongressuale GIS 💉 #MedicinaInterna