Finn McQuaid

@dopapus @LGosce @AGasparrini75 @ra_clark18 @juliapescarini @richardwhite321 @Rein_Houben @LSHTM_TB @lshtm_tbmod @LSHTM @LSHTM_Planet

WHO framework here: who.int/publications/i…

Our framework that informed the @WHO TB & climate change policy brief out now in @LancetRespirMed, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease thelancet.com/journals/lanre…

.@WHO is appalled and deeply shocked by reports of the tragic killing of more than 460 patients and companions at Saudi Maternity Hospital in El Fasher, #Sudan, following recent attacks and the abduction of health workers. Prior to this latest attack, WHO has verified 185 attacks on health care in Sudan with 1204 deaths and 416 injuries of health workers and patients since the start of the conflict in April 2023. Forty-nine of these attacks occurred this year alone, killing 966 people. All attacks on health care MUST STOP immediately and unconditionally. All patients, health personnel and health facilities must be protected under International Humanitarian Law. Ceasefire!

with Matt Saunders @Pranay_md Peter Cegielski @ra_clark18 @jaseddon18 Leo Martinez @dr_madhavib @dranuragb @richardwhite321 @reinhouben @LSHTM_TB @cmmid_lshtm @lshtm_tbmod

We think our recent review provides a better estimate of the RR leading to a much higher PAF, demonstrating the importance of addressing undernutrition to prevent TB. academic.oup.com/ije/article/54…

“Wow, I saw in the last GTB report undernutrition is much less important for TB than we previously thought” I hear you say… Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our piece here: thelancet.com/journals/lanin…

Our findings support the WHO's empirical BPaLM recommendation critical for settings with limited diagnostic access. @gmknght @SedonaSweeney @PLOSGPH @LSHTM_TB @lshtm_tbmod

When fluoroquinolone resistance status is unknown, empirical use of BPaLM (adding moxifloxacin to BPaL) is cost-effective as a replacement for BPaL even with high fluoroquinolone resistance levels!🦠💊 doi.org/10.1371/journa…

@Pranay_md @JamesASeddon @LSHTM_TB @lshtm_tbmod

Matt Saunders, Pete Dodd, @Pranay_md, Leo Martinez, @JamesASeddon #endtb

So...what would happen to the global TB epidemic if we hypothetically "eliminated" undernutrition? In this preprint, we combined estimates from our new review (doi.org/10.1093/ije/dy…) with population-specific BMI distributions to find out...(doi.org/10.1101/2025.0…)

Key message: Addressing undernutrition must be central to the global TB response. #EndTB @reinhouben @raclark18 @LSHTM_TB @lshtm_tbmod

Based on these results and the global BMI distribution, we estimated a relative risk of tuberculosis associated with undernutrition of 5.0 (95% CI: 4.2–5.9), substantially higher than previous estimates.

Nutritional status is a key determinant of TB. In this updated systematic review and dose-response meta-analysis (43 cohorts inc > 26 million people) we redefined the relationship between body mass index (BMI) and TB. doi.org/10.1093/ije/dy…