Michelle Wille retweetledi
Michelle Wille
27.6K posts

Michelle Wille
@DuckSwabber
Avian influenza & avian virome ecology | "Expert in Ducks" - spam mail | "Walking encyclopedia for avian influenza" - CVdS | (she/her)
Melbourne, Victoria Katılım Şubat 2014
4.1K Takip Edilen5.5K Takipçiler
Michelle Wille retweetledi
Michelle Wille retweetledi
Michelle Wille retweetledi

Cold chain matters, but alternatives exist.
Simple carbohydrates (e.g., trehalose, sucrose) can stabilize influenza RNA in swine oral fluids under field conditions.
Low-cost tools for better surveillance.
🔗 doi.org/10.3390/pathog…
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Michelle Wille retweetledi
Michelle Wille retweetledi

Michelle Wille retweetledi

Systems biology reveals H5N1 pathogenesis in ducks: RIG-I, TLR, NF-κB, and JAK/STAT pathways form a central antiviral network.
Key hub genes (e.g., STAT1, RIG-I, IRF7) drive host response → targets for intervention.
🔗 doi.org/10.3390/ijms27…
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Michelle Wille retweetledi

Good to see: trial of H5 influenza vaccine funded by CEPI, testing Moderna's mRNA candidate. We do not know if H5 bird flu can trigger a pandemic, but this information is important for preparedness. cepi.net/innovations-fo…
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Michelle Wille retweetledi

H3NX AIVs show reassortment, dual receptor binding, and efficient replication in mammals without prior adaptation.
Another subtype with clear zoonotic potential → surveillance is critical.
🔗 doi.org/10.1016/j.psj.…
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Michelle Wille retweetledi

Small changes, big effects → zoonotic risk
Seal-to-mammal adaptation in avian flu, including current 2.3.4.4b H5N1, is increasingly evident. NS1 is conserved, but few mutations can strongly enhance IFN antagonism, stability, & replication in human cells
journals.asm.org/doi/10.1128/jv…


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Michelle Wille retweetledi

AI-assisted coding directly inside your R session? Yes, it’s possible.
With the gander package, you can interact with AI without leaving R.
Set up your environment, connect your API key (for example, ChatGPT or Claude), and start writing prompts.
Why use gander:
🔹 Stay focused without switching tools
🔹 Speed up repetitive coding tasks
🔹 Get immediate feedback on your code and questions
🔹 Keep everything in one consistent environment
🔹 Work directly with your current R objects and data
The visualization below shows an example of a gander workflow: setting up the package, creating a heatmap with ggplot2, adjusting the colors, and making the result interactive with plotly, all through gander prompts and without writing the code yourself.
In a recent Statistics Globe Hub module, you will learn step by step how to use gander for AI-assisted coding in R, write effective prompts, and apply it to real data science workflows.
The Statistics Globe Hub is an ongoing learning program focused on practical skills in statistics, data science, AI, and programming with R and Python.
More info about the Statistics Globe Hub: statisticsglobe.com/hub
#AI #DataScience #RStats #Coding #Programming #DataAnalytics #statisticsglobehub
GIF
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Michelle Wille retweetledi

It's finally out! The first benchmark of a dedicated AI manuscript reviewer.
When we first launched R3 in June, AI review was still taboo. Since then, more tools have launched and more researchers have started experimenting with AI on their papers!
But how do these tools actually compare, both to each other and to human reviews? We wanted to contribute a benchmark to help the field make sense of all the recent progress!
We compare publicly available human reviews with R3 and frontier LLMs on thousands of papers -- across social science, life science, and computer science research.

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Michelle Wille retweetledi

Benchmarking of shotgun sequencing depth reveals the potential and limitations of shallow metagenomics and strain-level analysis | Nature Microbiology nature.com/articles/s4156…
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Michelle Wille retweetledi

Emergence of D1.1 reassortant H5N1 (clade 2.3.4.4b) in North America signals an evolutionary shift since mid-2024 linked to faster spread, expanded host range, increased reassortment, bovine spillover, & severe human infections, including non-farm workers.
biorxiv.org/content/10.648…
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Michelle Wille retweetledi

Michelle Wille retweetledi

Avian H5N1 (2.3.4.4b) infects mammary tissue across beef & dairy breeds: Angus, Holstein, Limousin. Both avian (α2,3) & human (α2,6) receptors present. The udder: an unexpected mixing vessel for influenza A reassortment. doi.org/10.64898/2026.…
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Michelle Wille retweetledi

Good news & a warning: Seasonal H1N1 infection boosts antibodies against H5N1 clade 2.3.4.4b... but NOT against clade 2.3.2.1a.
Cross-protection wanes by day 90. Your flu history matters depending on the H5N1 clade. doi.org/10.1080/222217…
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Michelle Wille retweetledi

H5N1 reassortment isn't random, it's seasonal. Ducks, geese & the Central flyway drive new genotypes as LPAI cases rise.
Spillover genotypes B3.13 & D1.1 emerged during peak mixing. Time to rethink pandemic risk assessment doi.org/10.64898/2026.…
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Michelle Wille retweetledi

sciencedirect.com/science/articl… Review of Oropouche by the technical advisory group on virus evolution, WHO
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