Marc Malone

410 posts

Marc Malone banner
Marc Malone

Marc Malone

@Iammarcmalone

1st Genes Restored Across Chromosomes and 1st Cancer Stem Cell Eradication in a human in history. Developed to save my late wife, perfecting to save my son.

USA Katılım Nisan 2025
123 Takip Edilen20.2K Takipçiler
Sabitlenmiş Tweet
Marc Malone
Marc Malone@Iammarcmalone·
Achieved the first human gene reprogramming to save my wife—restoring silenced genes, reversing tumor and cancer stem cells—no gene editing or toxicity. Now it is to save my son and 1 Billion others. We need: Scientists. Investors. Builders. #SavetheBoySavetheWorld #Biotech
English
49
66
461
76.3K
Marc Malone
Marc Malone@Iammarcmalone·
I wasn’t even suicidal when my wife died. Definitely not now - when I am my son's only chance of life. Also to be clear, I'm not afraid or paranoid. I have had no known altercations or incidents with anyone either. That being said, I have spoken to major podcasters (you will know them) - who want to be extra cautious with security before having me on their show, and I quote one particular said; "they will come after you hard". Hacking attempts have become more sophisticated, including coming from apparent major media companies. But I will say this: if you get in the way of me trying to save my terminal son - and the disabled, sick and dying children and wider community who are desperate for these therapies - you will be making a grave mistake.
Anna Paulina Luna@realannapaulina

If you are feeling uneasy about the amount of scientists that have gone missing, died, and recent suicides ref those scientists and others you are correct in your intuition. Something is up.

English
14
152
1.3K
71.2K
Marc Malone
Marc Malone@Iammarcmalone·
Good notes. In many cases you are right. I wasn't really intending for the sequence to be hierarchical but more 'cyclical', and there are toomany instances where the biochemistry would not solve the epigenetic damage (it requires accurate enzyme or RNA-protein signaling, Transcription etc.)
English
1
0
1
224
A.
A.@asymlab·
Respect for bringing real data instead of defending the quantum grift. You are spot on about DNMT1 hypermethylation locking up the BDNF promoter. But you have the hierarchy backwards. That epigenetic shift is secondary. It is the motherboard's panic response to the terminal Ca2+ dump. When those GluA2-lacking gates lock open, the oxidative fire forces the cell to suppress BDNF because the hardware is physically too fried to support new synaptic plasticity. It is peak junk code. Good thing to map, but you cannot fix the software (epigenetics) until you plug the hardware leak (Ca2+ influx). Leave the biochem work to us.
English
1
0
2
386
Marc Malone
Marc Malone@Iammarcmalone·
I'd recommend looking at the epigenetic damage likely exacerbating glutamate neurotoxicity. Strongly associated with conditions related to chronic neurotoxicity, stress, and psychiatric disorders Increased methylation (e.g. 5′-cytosine) levels at the promoter region of brain-derived neurotrophic factor (BDNF) gene, a critical modulator of synaptic plasticity and expression of DNMT1 is significantly increased in the hippocampus - and subsequent NMDA-mediated glutamate neurotoxicity.
Mikhaila Peterson@MikhailaFuller

We figured out that dad has a psych med induced neurological injury, and has been suffering from akathisia. It’s been 6 years since any psych medications. Last summer his symptoms started, after a flare up likely induced by mold (CIRS) and stress. It was complicated by pneumonia and associated sepsis a month later. It’s been horrible. Neurological injuries from psych meds are far more common than people know. I made this video to explain what they are and what akathisia is because they’re not talked about enough, they’re misdiagnosed, nearly impossible to treat, and hidden by the pharmaceutical industry. I don’t plan on making another update about my dad, it stresses my family out, and myself, and there’s nothing more to say about it until things get better. I will be jumping up and down about psych med injury awareness from now on as it’s impacted my health as well, and is devastating. Prayers are appreciated still.

English
13
8
114
20.8K
Marc Malone
Marc Malone@Iammarcmalone·
@lunarcycling Methylation patterns alone cannot, in coordination with RNR - it can. That being said it would support significant recovery, even biochemical modulation (at the correct level) would.
English
1
0
2
569
Nora Kased
Nora Kased@lunarcycling·
@Iammarcmalone If that's true, I'm not sure if DNA methylation repair can necessarily reverse the adverse effects in synaptic plasticity. It may prevent the worsening of symptoms, but epigenetic repair cannot negate years of taking medication that significantly alters neurouptake regulation.
English
1
0
5
1K
Marc Malone
Marc Malone@Iammarcmalone·
Some kind of toxicity dump (e.g. drugs or mold like CIRS) can cause sensitive neurological genes to tighten or shut down communication - which makes them not work - causes brain damage - and also sparks a cascade of chemical imbalances (toxicity) and inflammation. This is why chronic diseases are often not cured even when the cause (e.g. drug or mold or infection like Long Covid) is removed. The gene expression changed and the biology is trapped in that mode. Reversible, but with extreme accuracy and systems biology only.
Spiritus🌞@Mmagnet7

@Iammarcmalone Can you explain this in terms that everyone can understand?

English
5
4
62
7.7K
Marc Malone
Marc Malone@Iammarcmalone·
I can help him, and a million (or billion) others with <1% of the money in AI. But I can't do it alone, I have already made it this far - alone. No lab. No institution. No investment firms. Just desperation, my mind, my humble finances, and my dying family. My son has been the key to everyone else. His collapsing genome (disabilities and terminal decline) - forced a significant upgrade. The V1: first human proven multi-gene, multi-chromosome therapy + reversal of the most lethal gene silencing + cancer profile ever recorded (we did for my wife). Arran's V2 version will now be what it needed to be back then: broad-spectrum genetic therapy across *affected* genes and diseases. I am not the only desperate parent and family member waiting. I am the one though, who can help end it. I watched the person I loved most die (despite tripling her lifespan) because I was a couple months too late with the cure. I'm not gonna let that happen again.
Citrini@citrini

Posting for two reasons: 1 being if any of you can help this guy out. 2 being to remind everyone that if AI can shorten (even by a little) the time it takes to get drugs like these to the people that need them, then the trillions on compute will have been well spent.

English
18
23
72
10.8K
Marc Malone
Marc Malone@Iammarcmalone·
My son is losing his vision, his hearing, his gastrointestinal system, his neurons are dying from metabolic-neurodegenerative collapse, and his impending cancer would make his mother's most lethal ever cancer - look like a flu. It is happening faster than I expected. He is 50-100x more genetically 'mutated' than the next worst pediatric case on record. His being alive at all is actually (scientifically speaking) an anomaly of nature. His, mine and my late wife's suffering, and their gene expression recovery, their impossible disease (and disability) reversal however - is the true anomaly of miracle proportions. A miracle is actually more probable mathematically than my son surviving is. So when his vision improves, when he can finally talk, when he can tie his shoe laces, use a toilet, and when he lives a meaningful life instead of one of embodied-slavery to genetics, he will free so many others with him. This year - everything is to play for. A war I didn't ask for (again), but a price I will gladly pay for my precious boy and everyone else who is desperate like us. Self-determination and sovereignty will no longer just be for the able-bodied, because everyone is gonna have a shot to be abled-bodied. From my son to yours brother. I am gonna be pulling any and all levers possible (while retaining my soul) so we can finally end this - for us all.
inkedELCHAPO@inkedELCHAPO

@Iammarcmalone God speed Marc. Go all the way. Im waiting ready for my son!

English
33
14
196
33.4K
Stefano Martano
Stefano Martano@martano_ste·
@Iammarcmalone Hi @Iammarcmalone, I can't DM you cause I'm not verified, I'm working on a start up for precisione medicine in Europe, can you write me? I would like to know more about your research. Thanks
English
1
0
7
1.3K
Marc Malone
Marc Malone@Iammarcmalone·
Thank you everyone for building the community and coin: I hope it becomes another avenue of value outside of the institutional control system. Most of all, we have the only non-DNA editing gene therapy, and it surpasses any biomedical innovation ever. To get it ready for my son - and 1/3 of the entire world - proceeds for research will be essential and I hope this helps get us there asap because time is of the essence. Alonzo will video stream a conversation with me tomorrow or Thursday/Friday.
English
23
19
100
14.5K
Marc Malone
Marc Malone@Iammarcmalone·
@alonzocooks I don't know much about Crypto, I hope it helps grow a parallel economy alongside research. More control for the people, more healing.
English
4
2
13
2.6K
Alonzo
Alonzo@alonzocooks·
Looks like I was right 👀 Guy fudded me hard so you know it’s not a screenshot
0xalwaysearly@0xalwaysearly

Sorry to @alonzocooks for fud earlier Before I saw he CTO'd I messaged Marc as I didn't know the situation with the dev / fees but he just respond now This definitely is his coin as per his bags fee claim wallet also holding this

English
7
2
9
3K
Marc Malone
Marc Malone@Iammarcmalone·
@MarkusTheJames @MikhailaFuller Creatine is useful in some neuroimmune and psychiatric disorders. But I prefer to deal at the causal level (what biological mechanisms are causing the problem like biochemistry issues)
English
0
1
2
103
Mikhaila Peterson
Mikhaila Peterson@MikhailaFuller·
Mitochondrial research is the most interesting thing I’ve come across maybe ever. Ketogenic research and mold toxicity and psych med injury is all fascinating (and some of it horrible) but it all seems to converge on mitochondrial dysfunction. The research coming out in this area is revolutionary.
William A. Wallace, Ph.D.@WilliamWallace

Your urge to sleep may not start with neurotransmitters. A study published in Nature found that sleep pressure builds from mitochondrial electron leak in specific brain cells, and when the leak crosses a threshold, sleep fires.

English
46
72
664
146.2K
Marc Malone
Marc Malone@Iammarcmalone·
Useful to remember when my "one case" (the only multi-gene multi-chromosome & epigenetic therapy ever proven in a human) meets deaf ears. And CRISPR won the nobel for one case, and they haven't come close to what we did (10 biomedical firsts, including functional cancer cure + native DNA/RNA repair).
Chris Masterjohn@ChrisMasterjohn

When they are both equally well documented and correctly randomized, the greatest living founder of Evidence-Based Medicine completely agrees.

English
5
1
38
7.1K
Marc Malone
Marc Malone@Iammarcmalone·
I have the (human POC) fertility thing down with epigenetic restoration of endocrine genes and CNS. And have a version separate from my original Triune system to make it less wide in scope. As far as aging, I have something for that too. Which is perhaps the only 'disorder' not covered under the original IP/Platform. Entirely new territory.
English
0
0
7
467
Mgoes (bio/acc 🤖💉)
Mgoes (bio/acc 🤖💉)@m_goes_distance·
I’m tired of being performative with this biotech thing so I’ll be direct we're opening Superhuman Fund II soon our biggest focus is human enhancement(human 2.0) we’re funding science that pushes the frontier of human capability. examples: - peptides & protocols for peak performance and longevity - rejuvenation tech that actually moves biological age - fertility/embryo tech that changes the genetic baseline - hardware + robotics that augment human output if you’re building in that direction, I wanna talk. and if you're investing, we're qualifying LPs. DM for deets. bio/acc.
English
18
8
192
6.1K
Marc Malone retweetledi
Sylvia Fogel MD
Sylvia Fogel MD@FogelSylvia·
For autistic individuals with the highest support needs—and with disabling medical and neuropsychiatric symptoms—“awareness” and “acceptance” are not enough. We need a razor-sharp focus on translating scientific progress into effective, real-world treatments for co-occurring medical and psychiatric conditions, communication challenges, and the disabling aspects of motor and sensory differences. Prevention of the most severe and disabling outcomes must be front and center. This does not diminish the value of individuals as they are—but reflects a commitment to reducing suffering and maximizing chances for independence.
English
4
9
33
2.3K
Marc Malone
Marc Malone@Iammarcmalone·
@AlisonbobEth @MS_BASE44 I suppose I am the first functional cancer cure human proven case. Resources definitely needed for the patient program (but not a ton). Would love to do any agreement that means a) I keep my soul and b) cancer patients get the cure at reasonable cost
English
1
0
2
111
Maor Shlomo
Maor Shlomo@MS_BASE44·
I'm looking to invest in cancer research and breakthrough treatment companies Cancer is humanity's worst enemy, and unfortunately, it's one of the few frontier problems i don't see getting solved in the next 2-3 years.  I'll be able to write checks up to a few million (usually up to a million).  I will work extremely hard to help the founders. I'll leverage my network as much as possible to overcome bureaucracies and help hunt down talent for every company I'm investing in. Things I'm particularly interested in:  1. Accelerating clinical trials: As AI gets smarter and allows novel hypotheses on new drug targets, clinical trials and bureaucracy will remain the biggest bottleneck to fight cacner. 2. Repurposed drugs: the current cost of Phase 3 clinical trials only allows patentable solutions to be economically viable. It resonates that are probably many other treatments and potentially impactful drugs that won't be included in the Standard of Care as they haven't gone through phase 3 clinical trials.  3. Personalized medicine: organoids, digital twin, faster cycle from biopsy -> identifying targets -> creating customised solutions, such as mRNA vaccines, custom Antibody-Drug Conjugates (ADCs), and novel ways of triggering one's immune system.  4. Improving measurement: Currently, the standard PET-CT method does not allow weekly measurement of disease progression. Identifying a superior method to allow weekly measurement of progression could be instrumental in cutting down the time it takes to find a drug the body respond to. Anyone who can connect me to relevant companies will be widely appreciated
English
146
120
1.4K
102.2K
Marc Malone
Marc Malone@Iammarcmalone·
@FogelSylvia Likely monoallelic genes triggered by toxic metals or ammonia, and the inherited kind leans more on more allele zygosity and/or biallelic function loss, P.S. messaged you Dr, when you have a moment. Big movement this year to finally solve this issue.
English
0
0
0
85
Sylvia Fogel MD
Sylvia Fogel MD@FogelSylvia·
Important research finding: Mice with one copy of a risk gene, SHANK3, appeared normal at baseline. This gene is important for how brain cells communicate--changes in even one copy can increase risk for neurodevelopmental differences and autism. After an immune challenge (inflammation), they developed motor and behavioral changes. → The vulnerability was present but not apparent → Changes only appeared after the immune response This mouse study highlights the importance of understanding genetic vulnerability in the context of environmental and immune factors, not in isolation. 👇more below
Paul Whiteley@PaulWhiteleyPhD

Inflammation increases the penetrance of behavioral impairment in Shank3 haploinsufficiency mice - can it explain the behavioral regression in Autism? pubmed.ncbi.nlm.nih.gov/41882256/ The key role: inflammation. Which also implies infection as a possible driver of said inflammation too.

English
5
7
20
916
Marc Malone
Marc Malone@Iammarcmalone·
@BeLikeWahter As I said, very effective in many cancers - but many it is not. Just keep it real.
English
0
0
1
108
An echo in the chamber
An echo in the chamber@BeLikeWahter·
The number of people with cancer who are completely reversing their cancer with protocols centered around ivermectin and fenbendazol is going to be one of the greatest medical success stories in modern times. The fact the antibiotics doesn’t cure every infection in no way diminishes its status..
English
3
0
5
453
Marc Malone
Marc Malone@Iammarcmalone·
"Ivermectin cures cancer". Aren't you all tired of the science/medical bickering on this platform? Such lack of nuance in such life-critical areas never ceases to amaze me. Do we care about ideology or do we care about saving life? Ivermectin does not cure all cancers, because it leans heavily on already modifiable WNT (a primary cancer stem cell channel that drives cancer into existence) rather than inhibiting it wholesale. And does little for the other primary stem cell channels. It inhibits many critical signal pathways that induce apoptosis (cell death), but not all of them. Given so many cancers are glutamate and chloride upregulated, and the same glutamate-gated chloride membranes in parasites Ivermectin is designed to target - are targeted in cancer cells to induce cell death, to say it is "nothing" is anti-molecular biology and biochemistry. To say it is a "cancer cure" is also anti-reality. It is extremely effective in context-dependent cancer phenotypes. Not in all. Not in none. Just like *almost* everything else. The time has arrived for genuine science, and the political actors pretending to be scientists will be kicked out. Not by force - by their inadequate results. By patients and their families. By Truth itself.
English
19
4
80
11K
Marc Malone
Marc Malone@Iammarcmalone·
@Totoro_derGeist This was directed at practicing doctors and scientists, I encourage everyone to always do their own investigation and research and not rule things out.
English
0
0
2
697
Totoro
Totoro@Totoro_derGeist·
@Iammarcmalone What you say is true. But if it weren't for the 'unscientific babble' on this platform using Ivermectin as cancer medication would be unthinkable today. Remember that it started out as 'horse dewormer'.
English
3
0
1
840