Mike Rea

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Mike Rea

Mike Rea

@ideapharma

Pharmaceutical innovation geek. Author, Pharmaceutical Positioning. Senior Fellow @fastercures. Tweet about clients sometimes

Bradenham, Norfolk Katılım Ağustos 2010
1.6K Takip Edilen8.8K Takipçiler
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Daily Mail
Daily Mail@DailyMail·
Norwich is named best place to live in the UK in new guide - but did your home town make the top 10? trib.al/6TN8C9K
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Candel Therapeutics
Candel Therapeutics@CandelTx·
#DYK Our phase 3 trial of aglatimagene besadenovec (CAN-2409) in localized prostate cancer showed statistically significant improvement in prostate cancer-specific disease-free survival. We plan to submit a BLA in Q4 2026. #ProstateCancer #Immunotherapy $CADL
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Mike Rea
Mike Rea@ideapharma·
This is very good - and I’m one of those who bought a small farm solely as a big place to run around for my dogs… “If they saw what a good tractor cost they'd s*** themselves.” @JeremyClarkson
Larry Correia@monsterhunter45

Yeah, I know this is engagement bait bullshit from a European with no clue, but I see this kinda RETURN TO FARM post on X all the time, and it's always some idylic dreamscape of rural niceness, which makes it really fucking obvious to all of us who come from farming backgrounds that these people have zero fucking clue, and would probably end up wrapped around an auger on their first day. News flash. Farming is HARD. What these people are imagining is rural living on a big plot of land, where they've got income from something else, and maybe a couple of animals to keep down the grass and a little garden on the side. That's what I do now that I'm a rich guy. It's pretty awesome. I also know that if I had to make a living off this land I could probably do it (because unlike these weenies, I know how) but I don't want to, because it would absolutely fucking suck. Because in reality making a living off being a farmer is brutal. It's nonstop backbreaking labor where everything that can go wrong, will. And it will go wrong at absolutely the worst possible time. (especially if cows are involved!) Modern squishy internet people do not even sorta comprehend how hard farming is. I worked on dairy farms. I can't speak for the dirt farmers but I'm sure they've got their own set of wacky nonsense they get to put up with. It is LONG hours. I once did a stint opening up a new dairy where I worked 72 hours straight, with a couple of thirty minute naps in a truck or on the barn floor snuck in. There's nothing quite as fun as dealing with fifteen hundred pound animals and dangerous heavy equipment when you're so tired you're starting to see things that aren't there. Oh, and you'd better get real comfortable with blood, shit, piss, and death. Dealing with lots of farm animals is not for the squeamish. They're going to get sick, get injured, get stuck in infuriating and mysterious ways, and die stupidly on you. Every kind of livestock has got its peculiar way of being a pain in the ass. Cows are loveable, curious, stupid, and sometimes homicidal. I've been kicked, trampled, hooked, and smashed into/through fences. These sheltered idiot city people say crap like "go buy a farm" having zero comprehension of how much good farmland costs, or the insane costs of equipment, or livestock involved. If they saw what a good tractor cost they'd shit themselves. "Buy land"... Have you priced land? Oh, you can still buy cheap land, but it's usually cheap for a reason. As in you can't farm it, or it doesn't have water, or it's a nightmare hellscape of windy death. So farming is expensive to get into, hard to make a profit at, and insanely difficult the entire time. Oh yeah, and just when you think you've got it figured out, the government will absolutely fuck with you, because it's also super regulated. Yay. "skip the degree"... Lady, I got into college on an ag scholarship, and started out as an ag science major. Successful farmers are educated because this shit is complicated. (I then changed majors and got an accounting degree so I wouldn't have to pull calves at 3:00 AM, a decision which I have not regretted) These fuckers think farming is just strolling around in a sun dress picking wild flowers or some shit. Oh hell no. Farmers farm because they want to, and the juice is worth the squeeze for them.

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Mike Rea
Mike Rea@ideapharma·
Wow - I just saw that Sanofi’s new tagline is (yes, really…) “AI driven R&D company” If I took ‘Sanofi’ off this slide, would you have any idea which company this is? 😅
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strategicmind
strategicmind@austinvrabel·
$CADL amazing long tail results for NSCLC. Patients who failed ICI and docetaxel. Very sick patients. mOS was 25.4. SOC reference mOS of 9.8–11.8 months. approximately a two-fold improvement in mOS in this difficult-to-treat population. ir.candeltx.com/news-releases/…
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Dr. Paul Peter Tak
Dr. Paul Peter Tak@paulpetertak·
We are pleased to report updated clinical data for aglatimagene besadenovec (CAN-2409) in advanced non-small cell lung cancer (NSCLC) patients with inadequate response to immune checkpoint inhibitors. With an additional 12 months of follow-up, the data continue to strengthen the durability of the survival tail, with 50% of patients in the per-protocol population alive beyond 24 months and median overall survival of 25.4 months, approximately two-fold higher than historical outcomes with standard of care docetaxel in this setting. Equally important, these outcomes are supported by a compelling mechanistic package, including induction of pro-inflammatory pathways and expansion of T-cell receptor diversity, consistent with broad immune activation and “cold-to-hot” tumor conversion. Following our recent financing, we are well positioned to execute and are now advancing toward the imminent initiation of a pivotal phase 3 trial in non-squamous NSCLC. We believe this program has the potential to redefine outcomes for patients who have limited options after checkpoint inhibitor therapy. Thank you to the patients, investigators, and our team for making this progress possible. globenewswire.com/news-release/2…
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Mike Rea
Mike Rea@ideapharma·
Heard today that one of the big pharma wants people to use Pharma 2.0 as their base 😅 It’s 7 years old, and was an over complicated piece of crap then 😂
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Mike Rea
Mike Rea@ideapharma·
"commit to multiple TPPs now. Out-learn the competition, design advantage in, and let’s turn options into outcomes that transform patients’ lives. The second worst number of options is 1 - it’s the basis for almost everyone’s planning, even though it has never made any sense." ideapharma.substack.com/p/the-worst-nu…
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Dr. Paul Peter Tak
Dr. Paul Peter Tak@paulpetertak·
Today we reported our fourth quarter and full-year 2025 financial results and recent corporate highlights at Candel Therapeutics. Over the past year, our team continued to advance our mission of developing multimodal viral immunotherapies designed to help patients fight cancer. We made important progress across our clinical programs while strengthening the foundation for future growth and potential commercialization. Key highlights include: 1. Continued progress toward a potential BLA submission for CAN-2409 in localized prostate cancer 2. Advancement of our broader pipeline, including CAN-3110 in recurrent high-grade glioma 3. Strategic financing initiatives that strengthen our balance sheet and support future development 4. We remain focused on translating compelling science into meaningful therapies for patients with serious cancers. I am grateful to the patients, investigators, employees, and partners who make this progress possible. globenewswire.com/news-release/2…
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Lisa
Lisa@DrugDiscoverer·
I think we should all be able to live without chronic disease. Istesso is the embodiment of that vision; oral medicines that can repair and regenerate tissue- bone, lung, gut, and muscle.
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Mike Rea
Mike Rea@ideapharma·
If @PayPal are going to send me messages telling me I've got £6500 ready to pick up, but I haven’t actually sold anything, could they at least give me the thrill of making it seem more realistic 😅
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Candel Therapeutics
Candel Therapeutics@CandelTx·
Fierce covered our $100M royalty financing agreement with RTW Investments to support the potential U.S. launch of aglatimagene besadenovec (CAN-2409) for localized prostate cancer, pending FDA approval. We remain on track to submit our BLA in Q4 2026. fiercebiotech.com/biotech/candel…
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Dr. Paul Peter Tak
Dr. Paul Peter Tak@paulpetertak·
Thrilled to share an important milestone for Candel Therapeutics. Our abstract with new data has been selected for oral plenary presentation in the session “Practice-changing, Paradigm-shifting Clinical Trials in Urology” at the American Urological Association Annual Meeting 2026 in Washington, D.C. (May 15–18, 2026). globenewswire.com/news-release/2…
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