JAMA Neurology

Uniform amyloid PET cutoffs are supported for diverse older adult populations in #AlzheimerDisease clinical practice. ja.ma/3Nq7m1o

Patients with detectable virus-specific T cells before checkpoint inhibitor therapy in #PML demonstrated better survival rates and functional recovery than those without. ja.ma/4bhaupP

Biologically informed plasma #pTau217 thresholds improved diagnostic accuracy for amyloid PET positivity in patients with #CKD and #anemia vs a standard single cutoff, supporting cost-efficient biomarker implementation in #AlzheimerDisease screening. ja.ma/4cKq1Q2

Adults with #DownSyndrome and amyloid-positive #AlzheimerDisease had higher alignment between clinical and biological staging compared to sporadic cases. ja.ma/4uqzXo9

In 2025, JAMA Neurology saw a >15% increase in submissions, an Impact Factor of 21.4, >11.3 million article views/downloads, and >5,800 media mentions. 📄 Read the full “JAMA Neurology Year in Review, 2025,” by S. Andrew Josephson, MD. ja.ma/4bt5eOy

Higher circulating serum #klotho concentrations moderated the adverse association between brain atrophy and cognition in older adults at risk for #AlzheimerDisease but not in younger individuals. ja.ma/47vL8Sx

This case report describes a patient who presented with a 2-day history of dizziness, unsteady gait, and confusion. In the past month, he had experienced 2 cerebral infarctions and fungal infection in his left armpit. ja.ma/4uq01j1

PrimeC demonstrated comparable safety to placebo and showed slowed functional decline, reduced ALS-related complications, and modulation of iron-regulatory and microRNA biomarkers in adults with #ALS over 18 months of treatment. ja.ma/4sajyT9

In #RadiologicallyIsolatedSyndrome, greater paramagnetic rim lesion burden on MRI was associated with increased risk and earlier development of clinical #MultipleSclerosis. ja.ma/40u5xn9

Among patients with #Stroke and #PatentForamenOvale, the PASCAL classification system identified those likely to benefit from closure and those at risk of increased atrial fibrillation. ja.ma/4bo2Rg4

HHV-6 was identified as a rare cause of fulminant acute hemorrhagic leukoencephalitis in an immunocompetent adult. ja.ma/3N08wkj

Autopsy findings in individuals with chronic traumatic encephalopathy (#CTE) show frequent spinal tau and protein pathologies after repetitive head impacts, indicating spinal involvement in neurodegeneration. ja.ma/4bv6VLA

Among patients with chronic #stroke and severe contralesional impairment, targeted ipsilesional arm training supported significant and sustained improvements in ipsilesional motor performance vs best practice therapy. ja.ma/4ln864d

Editorial: Robust evidence links chronic air pollution exposure to increased risk and accelerated progression of #ALS. ja.ma/4cAH32V

Among adults with newly diagnosed focal #Epilepsy, suicidality at diagnosis was associated with more than double the risk of future drug resistance vs mood or anxiety disorders alone. ja.ma/4sCVIPS

Long-term residential exposure to fine particulate matter and nitrogen dioxide is associated with increased risk, faster progression, and greater mortality in #MotorNeuronDisease. ja.ma/4aZ0qQP

Interview with Hannes Vietzen, PhD, author Epstein-Barr Virus Antibodies to Differentiate Multiple Sclerosis From Other Neuroinflammatory Diseases. Hosted by Cynthia E. Armand, MD. ja.ma/4rgDC59

Persistently high Epstein-Barr nuclear antigen 1 antibody titers distinguished #MultipleSclerosis from #MOGAD and #NMOSD, supporting use as a noninvasive diagnostic biomarker. ja.ma/40Rhy6b

In patients with #AtrialFibrillation and recent #stroke, adding catheter ablation to oral anticoagulation did not significantly reduce recurrent stroke, systemic embolism, death, or hospitalization for heart failure compared to standard therapy. ja.ma/4ri4hOU

Among older adults with mild cognitive impairment, low-dose lithium did not significantly delay cognitive decline or affect neuroimaging and plasma biomarker outcomes over 2 years. Treatment was safe and well tolerated. ja.ma/3N2OQMB