JPGN

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Celiac disease in young kids ≠ classic 👇 <2 yrs: • ↑ vomiting, mood changes • ↑ poor growth • ↑ hospitalizations 2 yrs: more abdominal pain 👉 Watch for atypical signs 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #celiacdisease

IgA levels aren’t static in Celiac disease 👇 • 5.2% develop IgA deficiency • 31% regain sufficiency 👉 Impacts tTG-IgA reliability 👉 Consider routine monitoring 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #celiacdisease

No-biopsy diagnosis for Celiac disease 👇 • Works with TGA-IgA ≥10× ULN + EMA • Lower cutoffs risk misdiagnosis • Assay variability matters ⚠️ 👉 Use strict criteria 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #celiacdisease doi.org/10.1002/jpn3.7…

“Liquid biopsy” for Celiac disease? 👇 • 7-protein serum panel • ~90% accuracy vs matched controls • Noninvasive diagnostic potential 👉 Could reduce need for biopsy 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #celiacdisease #openaccess

Vedolizumab for pediatric IBD EIMs 👇 • 89% resolved by 18 months • ~50% needed adjunct therapy • No impact on treatment durability 👉 First prospective pediatric data 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #IBD

📊 The 3 most downloaded abstracts in Journal of Pediatric Gastroenterology and Nutrition (JPGN) in 23-25: ✔️ Cyclic vomiting syndrome ✔️ Helicobacter pylori ✔️ Pediatric feeding disorders 👉 Which of these do you find most challenging in your practice? #JPGN #ESPGHAN

🦴 CNO in pediatric IBD: • Can occur before/during/after IBD • Not tied to disease activity • Remission achievable—but complications possible 👉 Stay vigilant 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #IBD

Biologic safety in pediatric IBD 👇 • TNFi combo ↑ infection risk • Ustekinumab ↓ risk vs TNFi & vedolizumab • Vedolizumab ≈ TNFi 👉 Important differences for therapy selection 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #IBD

📚 Most cited in Journal of Pediatric Gastroenterology and Nutrition (JPGN): 🥗 Enteral nutrition 🦠 Probiotics 🥛 Cow’s milk allergy They are position papers with practical management guidance #JPGN #ClinicalGuidelines #PediatricNutrition #GutHealth

💊 MTX in pediatric IBD: • AEs common, rarely severe • Hepatotox 41%, nausea 46% • 38% discontinue ⚠️ Risk ↑ with male sex, dose, oral route 👉 Time for personalized monitoring? 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #IBD #openaccess

🤖 Predicting EEN success in pediatric Crohn’s: • ML models > chance • Uses routine clinical data • Step toward precision therapy 👉 Who benefits from EEN? We’re getting closer 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #IBD #CrohnsDisease #openaccess

💊 Anti-TNF in pediatric IBD: • Combo therapy ↓ failure (29% vs 57%) • Benefit seen in Crohn’s, not UC • Proactive approach ↑ durability 👉 Strategy matters 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #IBD #openaccess

🌍 Pediatric IBD & social vulnerability: • ↑ hospitalizations (dx + year 1) • Delayed remission • Differences fade by 1 year 👉 Early SDoH screening matters 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #IBD #HealthEquity doi.org/10.1002/jpn3.7…

💉 SC infliximab in pediatric IBD: • ↑ drug levels (median 19.6 μg/mL) • 85% continuation • Better QoL • Potential cost savings 👉 Convenient alternative to IV therapy 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #IBD doi.org/10.1002/jpn3.7…

⚡️ PENFS safety in pediatric DGBI: • ~10% mild AEs • Mostly local irritation • Rare systemic symptoms • No serious AEs 👉 Supports strong safety profile 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #DGBI doi.org/10.1002/jpn3.7…

💡 RCT in pediatric constipation: Adding low-volume transanal irrigation ➕ laxatives: • 75% response vs. 33% • More complete resolution 👉 Strong add-on option for refractory cases 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #Constipation #CME #openaccess

⚡️ Gastroparesis across ages: Younger patients undergoing GES have: • Similar nausea/vomiting • Less bloating/anorexia • Less fibrosis, fewer inflammatory cells 👉 Shared disease—but meaningful differences 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #Gastroparesis

🌀 Dolichocolon in kids: chicken or egg? Is it causing constipation—or resulting from it? 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #Constipation doi.org/10.1002/jpn3.7…

🌀 Dolichocolon is common in kids with constipation: • Up to 89% in ≤4 yrs • Declines with age • Linked to multiple GI symptoms May represent a congenital contributor to pediatric constipation. 🔗 doi.org/10.1002/jpn3.7… #pediatrics #pedsgi #Constipation #cme #openaccess