Journal of Physiology

Freddy L. Bueno-Palomeque (@unizar) et al. offer insights from clinical and computational data based on their research into #electrophysiological characterization of pre-adolescents born with intrauterine growth restriction 🫀 💻️ Read the study👇️ buff.ly/UAAcfW3

Charles Stark (@NorthwesternBME) and colleagues examine advances in cardiac devices and #bioelectronics augmented with #artificialintelligence in this #TopicalReview 🫀 💡 Read their work👇️ 🔗 buff.ly/8UddjU5

'Cardiac digital twins: Modelling the arrhythmic substrate of chemotherapy' Radomir Chabiniok (@childrens) & Vlad G. Zaha (@UTSWInternalMed) provide this #TranslationalPerspective on the work by Villar-Valero et al. (2026) ✍️ 🔗 buff.ly/2y71EnV

'Blood flow stasis improvements after simulated occlusion of the left atrial appendage in paroxysmal atrial fibrillation using 4-D computed tomography' Omar Hassan (@UCalgary) and co-authors present this #JournalClub on the work of Bäck et al. ✍️ 🔗 buff.ly/gc9Ag0a

'Seeing the heart in 3-D: Mapping arrhythmias across modalities' Callum M. Zgierski-Johnston (@UHZ_UNIFreiburg) and Jan Huisken (@uniGoettingen) offer this #Perspective on the work of Siles et al. (2026) ✍️ 🔗 buff.ly/ksoSO8e

Jie Yang and Eric A. Sobie (@IcahnMountSinai) emphasize the utility of integrating computational (‘dry lab’) models with information from experimental (‘wet lab’) datasets in future iPSC-CM studies💻️ 🔬 Read the review👇️ buff.ly/cGPO5D0

#Research by Vladimír Sobota (@ihu_liryc) and colleagues finds that the apicobasal dispersion of ventricular #repolarization in humans is associated with #age and affects arrhythmia vulnerability 🫀 🔬 Read the study👇️ buff.ly/qhr3rxB

'Small current, big potential: bridging mechanistic insight of the SK channel with translational promise' Yang Zheng (@uazmedphx) and co-authors present a #TranslationalPerspective of the study by Meier et al. (2026) ✍️ 🔗 buff.ly/sHr9rOU

'Combined inhibition of atrial-specific potassium currents as a possible anti-arrhythmic drug therapy: A match made in silico' Vladimír Sobota (@fondationbxuniv) offers this #TranslationalPerspective on the work of Dasí et al. (2026) ✍️ 🔗 buff.ly/RV9MOe9

🎓️ EDITOR'S CHOICE 🎓️ Anuradha Kulathilaka et al. (@ABI_bioeng) examined structural determinants of re-entrant drivers in atrial fibrillation, revealing insights from digital twins derived from 3D micrometre-resolution imaging of human heart 🫀 💻️ buff.ly/SJbNvE9

Caterina Vidal Horrach (@QMULSEMS) and colleagues explore how the combination of #experimental and #computational techniques can enhance our understanding of the arrhythmogenic effects of fibrosis💻️ 💉 Read the #TopicalReview👇️ 🔗 buff.ly/BR9gced

'From microgravity to hypergravity: Perspectives on circulatory adaptation through multiscale modelling' Dario Collia (@MountSinaiNYC) and co-authors offer this perspective on the work of Tripoli et al. (2026) ✍️ 🔗 buff.ly/efxA7Mi

In this study, Moritz Linder and colleagues observed that sympathetic stimulation can compensate for hypocalcaemia-induced #bradycardia in human and rabbit sinoatrial node cells 🔎 🫀 Read the #research 👇️ buff.ly/Ptfjzjb

'From molecule to bedside and back: the integration of computational and experimental physiology in the digital age' In this opening Editorial, Viviane Timmermann & Axel Loewe introduce the articles included in the latest special issue ✍️ 🔗 buff.ly/dYH8owx

Remembering Professor Alistair J. Gunn (1958–2026) 🔗 buff.ly/B9QSSPP This collection of his contributions to JPhysiol celebrates a remarkable scientific legacy. Professor Gunn was awarded the 2025 Prime Minister's Science Prize with Joanne Davidson and Laura Bennet.

Latest issue now live! 🎉 🫀 This special issue explores 'Integrating experimental and mathematical approaches to advance cardiac physiology research' 🎓️ Organised by Drs @axel_loewe and Viviane Timmermann Read the full issue here📖 buff.ly/464RdbQ

Martin G. Frasch (@UWMedicine) presents this #Opinion piece, 'Causal thinking in physiology: A search for vertically organizing principles' 💭 Available here👇️ buff.ly/szq5vA0

Jimena Siles (@HEartlab_ufabc) and colleagues present an integrated platform for 2-D and 3-D optical and electrical #mapping of #arrhythmias in Langendorff-perfused rabbit hearts 🫀 ⚡️ Read the article 👇️ buff.ly/ktA1zUB

Roberto Colangeli and Fiorenzo Conti (@UnivPoliMarche) observed that the endogenous #cannabinoid system gates plasticity of tonic #GABA inhibition 🔬 🧠 Read the study👇️ buff.ly/XAiEWQW

In this study, Albert Dasí (@CompSciOxford) and colleagues reveal that prospective in silico trials identify combined #SK and #K2P channel block as an effective strategy for atrial fibrillation #cardioversion 🔎 🫀 Read the research👇️ buff.ly/gx7efnC