Morgane Baldaccini

Circular RNAs trigger nonsense-mediated mRNA decay dlvr.it/TH6JJV

Researchers used AI to uncover 70,500 viruses previously unknown to science1, many of them weird and nothing like known species nature.com/articles/d4158…

A new Science study shows that Earth's severe Cryogenian glaciations catalyzed a pivotal shift in the evolution and diversity of early eukaryotes during the Proterozoic eon. The work underscores the interplay between Earth’s environmental perturbations and the evolutionary trajectories of early life. scim.ag/401cfS8

A new Science study presents a novel vaccine platform that improved protection against diverse influenza subtypes when tested in animal models and human organoids. Learn more: scim.ag/4gy8Kby

Climate change is driving global extinction risks, with 1.6% of species threatened at 1.3°C of warming and risks escalating to 29.7% at 5.4°C, according to a new meta-analysis in Science encompassing more than 30 years of research. Read more: scim.ag/4g8BQhx

Very sad to hear this news. Dr. Diane Griffin was an inspirational leader and scientist who was a pioneer in virology. She paved the way for other women to pursue and succeed in science. She will be sorely missed. Her legacy will live on 💐

A Perspective by Seder and colleagues considers present and historical paradigms of therapeutic cancer vaccines and describes a new approach, termed “Vax-Innate”, to generate robust tumor-specific T cell responses.nature.com/articles/s4157…

For readers interested in monoclonal antibodies to combat viral infections, here's a comprehensive review nature.com/articles/s4157… rdcu.be/dXnJh

BREAKING NEWS The Norwegian Nobel Committee has decided to award the 2024 #NobelPeacePrize to the Japanese organisation Nihon Hidankyo. This grassroots movement of atomic bomb survivors from Hiroshima and Nagasaki, also known as Hibakusha, is receiving the peace prize for its efforts to achieve a world free of nuclear weapons and for demonstrating through witness testimony that nuclear weapons must never be used again. #NobelPrize

Online Now: The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs dlvr.it/TF8hKM

The Many Shapes of Bacteria #bacteria #infographic #microbes #microbiology #science #bacteriology #biology #morphology #scientificart

For readers interested in RNAi drug design, including future directions, here's a comprehensive recent review tinyurl.com/czjpexm3 rdcu.be/dWpUE

The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified. Since their breakthrough, AlphaFold2 has been used by more than two million people from 190 countries. Among a myriad of scientific applications, researchers can now better understand antibiotic resistance and create images of enzymes that can decompose plastic. Read more about their story: bit.ly/3XI7KK3

This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms. Read how the 2024 medicine laureates’ investigations into C. elegans revealed an entirely new dimension to gene regulation: bit.ly/4dlPE6f #NobelPrize

MicroRNA genes have evolved and expanded within the genomes of multicellular organisms for over 500 million years. Today, we know that there are more than a thousand genes for different microRNAs in humans, and that gene regulation by microRNA – discovered by this year’s medicine laureates – is universal among multicellular organisms. #NobelPrize

Just published! AGOs loaded with tinyRNAs recognize specific target sequences in the 5' upstream region of the target site 𝒊𝒏𝒅𝒆𝒑𝒆𝒏𝒅𝒆𝒏𝒕𝒍𝒚 of the guide. We devised 𝑩𝒐𝒐𝒔𝒕𝒆𝒓𝒔 to load cityRNAs into endogenous AGOs, causing gene silencing. cell.com/cell-reports/f…

Online Now: Large-scale map of RNA-binding protein interactomes across the mRNA life cycle dlvr.it/TDS2Qd