Qi Chen (@qichen_lab) - Twitter Profili | Zamantika Mersobahis Locabet

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Qi Chen@qichen_lab·20 Ağu

Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation @NatureCellBio, where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA.🧵 rdcu.be/eBwPJ

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Qi Chen@qichen_lab·22 Şub

I fed this post/picture to Gemini's new Lyria 3 model, asking for a soundtrack based on the vibe. I wasn't prepared for the result... it captures the weight of this journey so beautifully that I'm almost in tears... What a time to be alive...

Qi Chen@qichen_lab

A road trip to Monument Valley and the wonders of the west, as an anniversary of lab’s 10th year operation…look forward to the journey ahead…

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Qi Chen@qichen_lab·20 Oca

1/5 It took us some time to connect the dots...now in @embojournal we use PANDORA-seq to start decoding the 'sperm RNA code of aging' We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵 link.springer.com/article/10.103…

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Qi Chen@qichen_lab·20 Oca

Perhaps the most puzzling part: We see a paradox: the rsRNA length shift is progressive⏳yet the global RNA profile shows an "Aging Cliff"📉. Cliff or Progression? Maybe the gradual shift is the forerunner—accumulating silently until it triggers the cliff. x.com/qichen_lab/sta…

Qi Chen@qichen_lab

1/5 It took us some time to connect the dots...now in @embojournal we use PANDORA-seq to start decoding the 'sperm RNA code of aging' We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵 link.springer.com/article/10.103…

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Qi Chen retweetledi

University of Utah@UUtah·23 Oca

Scientists discover a hidden RNA ‘aging clock’ in human sperm. New research from @UofUHealth sheds light on connection between paternal age and elevated health risks for the unborn. attheu.utah.edu/facultystaff/s…

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Eric Topol@EricTopol·20 Oca

Advanced paternal age is linked to adverse health outcomes of offspring. Discovery of how sperm age, enabling a sperm RNA code or aging clock link.springer.com/article/10.103… @EMBO

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Qi Chen retweetledi

Julie Kiefer@JulieCKiefer·21 Oca

New research led by @qichen_lab @UUHSResearch reveals an “aging cliff” in sperm RNA, a molecular marker tied to increased health risks in children of older fathers. This suggests a molecular clock tied to sperm aging in both mice and humans. Learn more: uofuhealth.utah.edu/newsroom/news/…

Qi Chen@qichen_lab

Perhaps the most puzzling part: We see a paradox: the rsRNA length shift is progressive⏳yet the global RNA profile shows an "Aging Cliff"📉. Cliff or Progression? Maybe the gradual shift is the forerunner—accumulating silently until it triggers the cliff. x.com/qichen_lab/sta…

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Qi Chen@qichen_lab·21 Oca

@mbarnalab @embojournal Many thanks Maria for the generous comment! Likewise to your trailblazing works!

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Barna Lab@mbarnalab·21 Oca

@qichen_lab @embojournal Congratulations! Your work is always super cool and interesting!

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Qi Chen@qichen_lab·21 Oca

@YehuMoran @embojournal Thank you very much Yehu!

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Yehu Moran@YehuMoran·21 Oca

@qichen_lab @embojournal Very cool, congratulations, Qi and team!

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Qi Chen retweetledi

Qi Chen@qichen_lab·20 Oca

2/5 The first revelation: In mice, PANDORA-seq uncovers a sharp "Aging Cliff"📉in sperm RNA profiles at mid-life—a non-linear shift distinct from chronological age. Crucially, this cliff signal (genomic & mitochondrial tsRNAs/rsRNAs) is invisible to traditional small RNA-seq.

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Qi Chen@qichen_lab·20 Oca

3/5 Perhaps the most surprising discovery: we see an age-dependent "Length Shift" in rsRNAs, exclusively found in sperm heads. Specifically, longer fragments accumulate while shorter ones decrease with age—a sign of altered RNA cleavage/processing efficiency (e.g., enzymatic).

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Qi Chen@qichen_lab·20 Oca

4/5 Crucially, beyond mouse data, we validated the sperm-head-specific rsRNA length shift signal in two independent human cohorts (longitudinal & cross-sectional). This suggests an evolutionarily conserved feature, which may stem from shared (enzymatic) mechanisms during aging.

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Qi Chen@qichen_lab·20 Oca

@HuaZhuOSU @embojournal Thanks Hua!

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Hua Zhu@HuaZhuOSU·20 Oca

@qichen_lab @embojournal Congratulations 🎉🎊

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Qi Chen@qichen_lab·20 Oca

@ZhouLabUCR @embojournal Many thanks Changcheng!

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Zhou Lab@ZhouLabUCR·20 Oca

@qichen_lab @embojournal Congrats, Qi and team! Pleased to be part of it.

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Qi Chen@qichen_lab·20 Oca

@EricTopol @EMBO Many thanks Eric for posting our new work! We provided here some further digest on the results: x.com/qichen_lab/sta…

Qi Chen@qichen_lab

Perhaps the most puzzling part: We see a paradox: the rsRNA length shift is progressive⏳yet the global RNA profile shows an "Aging Cliff"📉. Cliff or Progression? Maybe the gradual shift is the forerunner—accumulating silently until it triggers the cliff. x.com/qichen_lab/sta…

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Qi Chen@qichen_lab·20 Oca

Big thanks to the trainees & collaborators who made this happen! @Junchao_Shi @XudongZhang_RNA @cai000chen @happy_jjcc @ShichaoLiu4 @ZhouLabUCR @tongzhoulab @jimhotalingmd @aaronquinlan @shishenyxx @EmmaRae9 @JKunisaki Enabling new biology with PANDORA-seq x.com/qichen_lab/sta…

Qi Chen@qichen_lab

Great to see our PANDORA-seq nature.com/articles/s4155… & Perspective on the exploration of small RNA universe nature.com/articles/s4155… both highlighted @NaturePortfolio among the collection of key methods & resources of the noncoding RNA field👇 nature.com/collections/ce…

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Qi Chen@qichen_lab·20 Oca

5/5 Connecting mouse and human sperm data to uncover this conserved rsRNA length shift has been a privilege. Made possible by unique resources at @UtahUrology @UofUMedicine @UofUResearch @huntsmancancer, seeding translational potential with future cohorts & validation...

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Qi Chen

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