Carlos Andrés Regino

Enjoy!!! frontiersin.org/journals/medic…

🚨 Big news in cellular therapy! 🚨 FACT and @JACIE_EBMT have officially released the Standards for Hematopoietic Cellular Therapy (HCT), 9th Edition and the Standards for Immune Effector Cells (IEC), 3rd Edition demonstrating our ongoing commitment to promoting quality, patient safety, and excellence in medical and laboratory practice worldwide. 🌎🫂 What’s new? ✅Updated International Standards for HCT and IEC ✅Fresh Accreditation Manuals to guide your journey ✅Downloadable Summary of Changes and Resource Links to keep you informed 📕HCT: factglobal.org/standards/hct-… 📘IEC: factglobal.org/standards/immu… #CellTherapy #FACTStandards #FACTaccreditation #ImmuneEffectorCells #PatientSafety

Heart Transplantation for Cardiac Amyloidosis: Mayo Clinic Consensus sciencedirect.com/science/articl…

Management recommendations for kidney transplantation in patients with plasma cell dyscrasia - Kidney International kidney-international.org/article/S0085-…

Prophylactic IV magnesium administration was associated with a lower risk of cisplatin-associated acute kidney injury (CP-AKI) in patients with cancer undergoing cisplatin chemotherapy. ja.ma/445u6s6

Screening for monoclonal gammopathy of undetermined significance is contraindicated buff.ly/13LCjeJ

Diagnosis, management, and outcomes of drug-induced erythrocytosis: a systematic review @BloodAdvances ashpublications.org/bloodadvances/…

4/4 Clásicos ✅

💙 𝐅𝐂 𝐁𝐀𝐑𝐂𝐄𝐋𝐎𝐍𝐀 ❤️

Understanding P-Values is essential for improving regression models. In 2 minutes, I'll crush your confusion. Let's go:

🚨 Association of Specific Antiphospholipid Antibodies to Platelet Count and Thrombocytopenia ⬇️ 📌 Griem et al. found anti-β2GPI IgG 🔗 with low #platelet count 📌 anti-β2GPI IgG aPL may induce #thrombocytopenia by chronic platelet consumption 👉📖 thieme-connect.de/products/ejour…

🧬Generations of CAR-T Cells 1️⃣First Gen: CD3ζ signaling only 2️⃣Second Gen: Added co-stimulatory domain (CD28/4-1BB) →better expansion & persistence 3️⃣Third Gen: Dual co-stimulatory domains for enhanced efficacy 4️⃣Fourth Gen: Cytokine inducers for optimal proliferation #CARTCell

How to read a paper? Here are 7 guides on how to read and interpret different types of research papers:⬇️

Let's learn hematology in 2025🩸 Day 12: diseases and antigens, simplified

Pros and cons editorial: Ofran and Rowe support the current practice of treating relapsed patients with acute myeloid leukemia with chemotherapy prior to transplantation, with notable exceptions. haematologica.org/article/view/1…

The current landscape of frontline large B-cell lymphoma trials ow.ly/xNUj50UCM6P #clinicaltrialsandobservations #immunobiologyandimmunotherapy #lymphoidneoplasia

Explore the newly published ISTH Hemophilia Guidelines with a critical review by @GuyYoungMD et al. in the latest #JTHinClinic article. #Hemophilia #Guideline 🔗jthjournal.org/article/S1538-…

🚨 Vancomycin vs. Daptomycin vs. Linezolid: A Comprehensive Clinical Guide 🦠💉 Antibiotic choices for Gram-positive infections like MRSA and VRE require precision! Here’s your quick guide to these key agents: ✔️ Vancomycin: 🏆 First-line for MRSA bacteremia, pneumonia, and more. 📊 Dosing: Weight-based (15–20 mg/kg q8–12h). Use TDM to target AUC/MIC ≥ 400. ⚠️ Adverse Effects: •Nephrotoxicity (monitor renal function). •“Red Man Syndrome” with fast infusion (prevent with slow infusion + antihistamines). 🔑 Tips: •Monitor troughs (15–20 μg/mL) and adjust for renal function. •Avoid prolonged use in patients with high nephrotoxicity risk. ✔️ Daptomycin: 💪 Ideal for MRSA/VRE bacteremia and endocarditis. ❌ Not for pneumonia (inactivated by pulmonary surfactant). 📊 Dosing: 4–10 mg/kg IV daily (adjust for renal function). 🩸 Adverse Effects: •Myopathy and rhabdomyolysis (check CK weekly). •Rare: Eosinophilic pneumonia. 🔑 Tips: •Avoid in pulmonary infections; use for bloodstream or cardiac infections. •Monitor CK closely, especially in patients on statins. ✔️ Linezolid: 🌟 Best for pneumonia, VRE infections, and oral outpatient care. 💊 Flexible dosing: 600 mg IV/PO q12h (no renal adjustment needed). ⚠️ Adverse Effects: •Myelosuppression (check CBC weekly). •Peripheral/optic neuropathy with use > 28 days. •Risk of serotonin syndrome with SSRIs. 🔑 Tips: •Avoid prolonged therapy to reduce neuropathy risk. •Ideal for long-term infections like osteomyelitis. 📌 Summary: DrugBest ForAvoid IfKey Monitoring VancomycinMRSA bacteremia/pneumoniaProlonged nephrotoxic riskTroughs, renal fx DaptomycinMRSA/VRE bacteremia/endocarditisPneumoniaCK weekly LinezolidVRE, pneumonia, long-term therapy> 28-day therapy (neuropathy)CBC weekly 🩺 Optimize Therapy: Choose based on infection site, resistance, and patient factors. #InfectiousDiseases #Antibiotics #Pharmacology #MedTwitter

How I treat Philadelphia chromosome–like acute lymphoblastic leukemia in children, adolescents, and young adults ashpublications.org/blood/article-… #leusm

Delighted to present our FREE TO READ Annual Review Issue on #hempath ‘Beyond the Current Classifications’ edited by Prof Daphne de Jong and Prof Torsten Haferlach onlinelibrary.wiley.com/toc/13652559/2…