Stuart Schreiber

1/4 A Perspective on proximity-inducing #molecularglues and bifunctional compounds in relation to hot-spot-associated missense mutations enshrined by natural selection and posttranslational modifications (PTMs). chemrxiv.org/engage/chemrxi…

5/5. If machines do eventually achieve consciousness, it will likely require a radical rethinking of both neuroscience and computer science.

4/5. A brain’s memories are dynamic rather than fixed, continually reconstructed through experience and changes in neural circuitry in ways that help maintain a coherent sense of self.

Conscious AI? 1/5. The flawed "brain is a computer" metaphor underlies much of the speculation that AI will eventually achieve consciousness. Like many in the biomedical community, I find that unlikely for several reasons mentioned here:

1/2 Why AI is unlikely to become conscious – my 2026 @TEDTalks is now online. What do you think about the prospects for 'conscious AI'? ted.com/talks/anil_set…

We found that participants in China attribute more consciousness to LLMs than participants in the UK. Interestingly, UK participants attribute more consciousness to octopuses. If you’re interested in cultural differences or AI anthropomorphism, come say hi👋

A thoughtful and easy read from Angie You (@Angiejyou) on basic research as a driver of next-generation therapeutics, noting here clinical data from Revolution Medicines linkedin.com/posts/angie-yo…

Otsuka Unveils New Repinatrabit Open-Label Extension Data in Phenylketonuria (PKU) Signaling Efficacy in Adolescents at the 2026 American College of Medical Genetics and Genomics (ACMG) Meeting otsuka-us.com/news/otsuka-un…

Bravo! 🎈 magazine.scripps.edu/awards-and-hon…

What a thrill to see this out! Our prospective, scalable, and target-centric solution for molecular glue discovery. More thoughts and details here: linkedin.com/posts/activity… Paper here: nature.com/articles/s4158…

Thanks to Senior Editor @stephgreed at @NatRevChem for this opportunity to discuss chemical biology rdcu.be/e22bz

@JohnCendpts Sending white light. ❤️

The Merkel cell carcinoma log # 485. The often unpredictable nature of an advanced cancer diagnosis has left me in a permanent defensive crouch that abates but never goes away. The first thought: This shit is really happening to me. That’s followed by a full set of doubts about positive responses. What does this PET scan really say? When does this thing turn around like a dream monster, ready to devour me? The first thing I thought when I heard I had a clear PET scan a few weeks ago, as I told my wife, was: I Just don’t trust it. On Friday I was in for my second infusion at Dell Seton, which to the best of my knowledge doesn’t have an electronic medical record I can see. No one ever discussed my bloodwork from the first infusion. This time, the nurse who handled the infusion hands me a printout on the bloodwork, says my oncologist says my ALT levels are concerning and I should get a CT scan for liver damage. Here’s the phone number. On your way now. My ALT levels were doing just fine until then. And I can read my bloodwork results now as well as any PA. A sudden and unexpected jump to 251 is what you call a no-shit serious concern. The concern is whether the avelumab is triggering an immune attack on the liver. I’m not overreacting. I confirmed it with my digital cancer cabinet. (And how many times have I written up versions of the fatal ALT flaw covering clinical trials over the last 24 years?) So we turn from the good stuff to the bad stuff, just like that. For cancer patients, there needs to be a more balanced, consistent approach on communications. I’ve experienced every level of dysfunction and quality care — the best and the worst. There is clearly no industry standard at work here. For patients, it’s a requirement to stay constantly vigilant and knowledgeable about what’s going on. And do what you need to do to get outside advisers to review and advocate for you. The best care is not guaranteed, you need to understand you’re more on your own than you’d like. I have a lot of advantages. And I recognize that. Here in Austin, a solid majority of people getting infusions where I am can’t speak a word of English. They have an effective translation program in place, but how much gets lost in the exchange? What’s happening in the margins, where routine questions never go? For the first time, more than 2 million people will be diagnosed with cancer in the US this year. Cancer treatment needs to be reformed. Living with cancer is a challenge. We have to realize that quality is dangerously variable and this system of myriad interruptions and expensive obstacles to care is unworkable. Cancer patients need to get educated and speak up to demand change, at a time when the law requires silence and people are least capable of acting up.

Thanks to friends, colleagues, current and former group members, and the Welch Foundation for this video linking molecular glues, expanded genetic codes, and chemical biology youtube.com/watch?v=L9PyDF…

So pleased to team up with Pete Schultz on this special occasion

Arena Founder and CSO @SchreiberStuart answers questions about #chemicalbiology and #molecularglues

I’m excited to team again with my long-time friend and colleague @HarveyJBerger at @arenabioworks. We can already feel the magic of the Ariad days as we translate Arena discoveries to high-impact medicines

Excited to see this dynamic duo tackling high-impact biomedicine – among others, AI for reasoning on human evidence and AI for informed therapeutics forbes.com/sites/sindhyav…

Outstanding @morgancheatham @NEJM_AI

Under this ownership group, the Celtics won two championships and built a culture of camaraderie and resilience. Steve's deep loyalty to Boston makes him a champion both on and off the court, leaving a legacy that will forever inspire Celtics fans and Bostonians alike.