Sheng S.-H. Chen

Struggling with co-staining in frozen tissue because multiple antibodies share the same host species? We developed Cryo-4i, a modified 4i-based method for simple, cost-effective multiplex immunostaining in frozen tissue. Protocol now available: doi.org/10.1016/j.xpro…

CLASSIC!

In the latest issue! ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1 dlvr.it/TKtGK0

Is the genome just a bag of genes? A new paper in @ScienceMagazine now reports that for two thirds of an organisms' genes the position along the chromosome is actually very tightly constrained! Amazing work from my favorite night scientist @MartinJLercher and his team!

Opto-p53: A Light-Controllable p53 Signaling for Regulating p53-Dependent Cell Fate. biorxiv.org/content/10.110… #biorxiv_synbio

We are happy to share our new preprint reporting Opto-p53, an optogenetic system that activates the p53 pathway with light! Opto-p53: A Light-Controllable p53 Signaling for Regulating p53-Dependent Cell Fate.

Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional), we mapped week-by-week changes starting from preconception to months-long postpartum recovery.

We are recruiting PIs at all levels @AcadSinica @IMBSinica, with guaranteed life-term stable intramural grant support until you retire! We dont need to make anything great again, as we have been always GREAT! nature.com/articles/d4158…

Join us at the Quantitaive Microbiology Symposium next Mon and Tue at Academia Sinica in Taipei! sites.google.com/view/qmicrob20…

Our Phage infection/T6S story is finally out @embojournal ! "Surface-mediated bacteriophage defense incurs fitness tradeoffs for interbacterial antagonism" Led by my wonderful team @AcadSinica @IMBSinica embopress.org/doi/full/10.10…

Only 4 days left to register. I hope to see many new ferroptosis researchers in Chicago!

I would like to express my gratitude for the research grant supported by the National Multiple Sclerosis Society. @mssociety This three-year grant will help us advance our understanding of meningeal B cells and their role(s) in multiple sclerosis!

The deadline for the following grants is 7 March: -Scientific Meeting Grants -Grants from our Fund for Innovations in Sustainable Conferencing - JCS-FocalPlane Training Grants (@J_Cell_Sci @focalplane_jcs) Find out more and apply at biologists.com/grants

Hello everyone! I am helping to organize a one-day symposium on fluorescent metabolite biosensors and their use in metabolism research. It will be May 12-13 and associated with the Cold Spring Harbor Laboratory “Mechanisms of Metabolic Signaling” Symposium. Our field needs to be able to visualize metabolism with spatial and temporal resolution and this symposium will explore what to do and how to do it, with experts in metabolism and biosensor development and use. Please join us! meetings.cshl.edu/meetings.aspx?… -JR

Only a few days remaining, and I’ve been reading some great submitted abstracts! Exciting new findings to be shared at the meeting!

Science is under threat! Worldwide, forces seek to make it corporate-like, focused on deliverables, or even the enemy of society. It's time to take a stand to celebrate the science we know & love. Introducing: Woodstock.Bio2 + Night Science June 10-13, Prague & Woods of Bohemia

We extended the deadline on the #Chicago #ASBMB #Ferroptosis meeting! 12 short talks will be selected from the abstracts. Register for what we expect to be a great conference.

We are hiring! Work in Taiwan with an NIH-scale salary! Please RT!

Mismatch repair and homologous recombination are yin-yang partners in hybrid zygote meiosis biorxiv.org/content/10.110… #biorxiv_genetic