Sjaak Bral

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Sjaak Bral

Sjaak Bral

@SjaakBral

Geluk is: blij zijn met wat je niet hebt.

Hieâh! Katılım Haziran 2009
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Sjaak Bral
Sjaak Bral@SjaakBral·
Nieuwe speellijst Vaarwel 2026! Op de website. Koop je kaarten online bij het theater en niet via malafide ticketshops. sjaakbral.nl/voorstellingen
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Anish Moonka
Anish Moonka@anishmoonka·
Take too much Ozempic, and your brain stops wanting things: food, sex, even the urge to get out of bed. People end up in hospital beds for days, staring at the ceiling, feeling nothing. The medical name for that state is anhedonia, and it tells you how the drug actually works. Ozempic, Wegovy, and Mounjaro all belong to the same drug family, called GLP-1s. They kill hunger. They also quiet almost every other craving your brain produces. Inside your brain there is a small region that makes a chemical called dopamine. Dopamine is your brain’s “this is worth wanting” chemical, the reason you reach for one more bite of pasta, refresh your inbox one more time, or pick up your phone every few minutes. GLP-1 drugs reach that region and turn the dopamine down. The right dose dampens the loudest craving first: food. Take too much, and the volume drops on everything else, sex, exercise, work, even the urge to get out of bed in the morning. Anhedonia is the medical name for not feeling pleasure from anything at all. It looks identical to deep depression. The good news is that anhedonia from GLP-1s has an off switch: once the drug clears your system, the wanting comes back. The FDA has logged over 1,150 reports of bad reactions tied to compounded GLP-1s through July 2025. These are custom-mixed versions made by smaller pharmacies. In many of those cases, patients accidentally took five to twenty times their prescribed dose. The cause is usually confusion between milliliters and units when measuring out a dose with an insulin syringe, since compounded versions come in plain vials instead of the pre-filled pens that brand-name Ozempic uses. About 15 million Americans currently use a GLP-1, roughly one in eight adults. Around 75% of them eventually quit. Cost and side effects are the top reasons. A growing number describe a third reason that patients call “the lights dimming,” a flat, gray feeling across the whole day that doctors now recognize as anhedonia caused by the drug itself. This same mechanism has caught pharma’s attention. Eli Lilly is now running two large clinical trials with a combined 2,200 patients to see if a GLP-1 drug can treat alcohol addiction. The bet is that the same brain switch that turns off cravings for food can also turn off cravings for alcohol, cocaine, nicotine, and gambling. A 2026 psychiatry review put it bluntly: doctors should be treating these as psychiatric drugs, because that is what they have turned out to be. The drug works by quieting your brain’s signal that something is worth wanting. A normal dose turns the volume down on food cravings. Push the dose too high, and everything else goes quiet too.
Overlap: Business & Tech@Overlap_Tech

Sam Altman Overdosed on GLP-1s⁣ ⁣ "Taking enough of it makes you have not a desire for anything else. Few days laying in a hospital bed staring at a white ceiling thinking nothing, not wanting anything." — @sama

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Sjaak Bral
Sjaak Bral@SjaakBral·
NIEUW! Haagse Harry sportsokken. Maat 36/40 en 41/46. Pre-order: stuur een mail naar info@haags.nl
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Sjaak Bral
Sjaak Bral@SjaakBral·
Koningsdag is een jaarlijkse processie van polyester, zonder oranje kledingstuk ben je sociaal irrelevant ad.nl/den-haag/konin…
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Sjaak Bral
Sjaak Bral@SjaakBral·
Kleine Diederik verkoopt tegenwoordig lauw opgewarmde Zweedse balletjes, met een app om mee te pinnen ad.nl/den-haag/klein…
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Sjaak Bral
Sjaak Bral@SjaakBral·
Ingehaald door de actualiteit. PvdD uit College van B&W gezet om deze reden. Oeps!
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Sjaak Bral
Sjaak Bral@SjaakBral·
@RaafRob Dank je Rob! Ja die is alvast in de hemel.
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Rob Ravestein
Rob Ravestein@RaafRob·
Mooie stukkie in het AD @SjaakBral , mooi voor je vadertje ook 💛💚
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Sjaak Bral
Sjaak Bral@SjaakBral·
Kampioenûh!!!
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henk westbroek
henk westbroek@henkwestbroek·
Dit moesten julia en ik van mij dochter aantrekken toe we gisteren per totale verrassing een huwelijksfeest kregen aangeboden. Leukste feest van de laatste tien jaar. Kwam vooral door de 50 lieve gasten.
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Sjaak Bral retweetledi
Corien Glaudemans
Corien Glaudemans@corien_glaud·
Ook @SjaakBral is een fan van de Akte van Redemptie. De wat? Ja de Akte van Redemptie uit 1576, de beschermer van het Haagse Bos, het Malieveld en de Koekamp. Een column van Sjaak en een tentoonstelling in het Haagse stadhuis!
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