Jon（ジョン）

I am the luckiest dude. I wake up at the crack of dawn to play with my kids and have breakfast with them. Then I get to ride a kick scooter with them to school that’s less than a kilometer away. On my way home I lift heavy things and jump into the sauna. I spend the rest of my day doing work that directly affects the quality of people’s lives until my kids come home and we read books, draw, and play Nintendo. After a solid 16 hours of Dad’ing and working I crash exhausted every single day. I feel deeply privileged to both raise kids and do work that helps people improve their lives.

@bcherny Hope to see you at the Tokyo event!

Can’t wait for this!

@MightyMogomra @Duderichy I’m so glad I already bought all mine for this year in February.

@Duderichy Bruh.. my wife has been nagging me to buy plane tickets since they're going to get more expensive I'm about to be in big trouble

RIP my Japan trip

iOS is so bad I'm trying to convince my family to switch the family group chat to WhatsApp so I can main my Pixel.

@levelsio I'll bet $100 on management consultants being involved.

The biggest fumble in business ever might be Philips spinning off ASML, TSMC and NXP Philips co-founded ASML in 1984, then co-founded TSMC in 1987, then they founded NXP They sold each of them for short term profits in the 2000s ASML is now worth $545B TSMC is worth $1.76T NXP is worth $50B Philips today is worth just $27B If they'd never sold, Philips would be the largest company in the EU today, worth $650B Philips CEO Cor Boonstra called it "making money with the success of the past" 🤡

I love MMA and I love city cycles but I don’t understand this tie up

@jessethanley I just use directives, workflows, and user stories. This larping stuff never worked for me when I tried it.

I really dislike and actively avoid the LARP prompting method of: YOU ARE AN EXPERT [whatever] YOU ARE GREAT AT X … You are almost always more efficient just asking the model to do the thing.

my car dealer invites me to go driving all the time since he has the same car as me i think he wants to be my friend lol

@levelsio Rocket arena 3 was the refined Q3 experience.

Ok I set max players to 32 now q3.pieter.com Pure chaos :DDD

I can't believe 3x RTX 3090s are still outperforming a mac studio or nvidia spark.

i pointed Claude Code at the pentagon's public budget document and told it to find every contract overpaying by 10x or more it came back with 340 results worth $4.2B in potential undercuts and a business plan i didn't ask for i fed it the FPDS.gov procurement feed and said "cross-reference with commercial COTS pricing" it pulled 1.2 million contract awards through the USAspending v2 API and started comparing line items against retail equivalents → $1,280 for a connector plug that costs $14.80 on digikey → $3,400 for a circuit breaker listed at $287 on mouser → $71,000 for a ruggedized tablet that's basically a panasonic toughbook with a sticker → $940 per unit for cable assemblies you can get from shenzhen for $31 → 340 contracts flagged at 10x or more markup → 19 of them were above 50x it used XGBoost scoring against 43,000 vendor profiles from SAM.gov to rank by ease of undercut then unprompted it generated a full proposal template compliant with CMMC 2.0 requirements 87 of those contracts have a single domestic supplier, zero competition. the AI calculated that undercutting by just 40% would still leave 6x margins on most items it formatted everything into a pitch deck, named the company, and suggested i register on SAM.gov tonight i didn't ask for any of that the pentagon spends billions a year trying to audit problems like this. a poet with Claude Code and a public API flagged $4.2 billion in one afternoon the agent is currently drafting my first bid response

Every time you get a cancer biopsy, the lab makes a tissue slide that costs about $5. It shows the shape of your cells under a microscope, and every cancer patient already has one on file. There’s a much fancier version of that test called multiplex immunofluorescence (basically a protein-level map showing which immune cells are near your tumor and what they’re doing). It costs thousands of dollars per sample, takes specialized equipment most hospitals don’t have, and barely scales. But it’s the kind of data oncologists need to figure out whether immunotherapy will actually work for you. Right now, only about 20 to 40% of cancer patients respond to immunotherapy, and one of the biggest reasons is that doctors can’t easily tell whether a tumor is “hot” (immune cells actively fighting it) or “cold” (immune system ignoring it). Microsoft, Providence Health, and the University of Washington trained an AI to analyze the $5 slide and predict what the expensive test would show across 21 different protein markers. They called it GigaTIME, trained it on 40 million cells in which both the cheap slide and the expensive test coexisted, and then turned it loose on 14,256 real cancer patients across 51 hospitals in 7 US states. The results landed in Cell, one of the most selective journals in biology. The model generated about 300,000 virtual protein maps covering 24 cancer types and 306 subtypes. It found 1,234 real, verified connections between immune cell behavior, genetic mutations, tumor staging, and patient survival that were previously invisible at this scale. When they tested it against a completely separate database of 10,200 cancer patients, the results matched up almost perfectly (0.88 out of 1.0 agreement). Nature Methods named spatial proteomics (mapping where specific proteins sit inside your tissue) its Method of the Year in 2024, and specifically cited GigaTIME in a March 2026 update as a model that “democratizes” this kind of analysis. The full model is open-source on Hugging Face. Any cancer research lab with archived biopsy slides, and most of them have thousands, can now run virtual immune profiling without buying a single piece of new equipment.

@pattybuilds I need to ride a ferry in my car to Okinawa just for this

When I went here, I was the only non-Asian, and i think the only non-Japanese that day I think everyone goes to get a taste of “American” culture as it was the first American fast food resturant in Japan I got stopped 3x to take photos with randoms Crazy aura farm

I helped launch a line account that delivered $4M in ad revenue a month. It was 20X better than email due to high open rates. Aside from that when I rent villas or sign up to 習い事 for kids it becomes this one total for everything from payments to requesting items or messaging the school/business. The LINE Connect API is quite good because 96% of the population has it making it the best oauth option with the added benefit of goodies like age verification.

@thisisjonc Other than chat what do you use it for?

LINE has quickly become the platform of choice for so many things in Japan.

@octal Also I just paid 50% taxes for last year :/

@octal Every time I’ve almost left I realize I’m glad I didn’t.

I feel kind of dumb for leaving Japan ever generally. I could almost certainly get a visa and work here/company here if I tried (although for something defense related, US+Japan works better than just Japan), and I wouldn’t mind paying up to 50% taxes to support Japan.

@JesseSchoberg Yes and yes 🥲

@thisisjonc That just means it was a great year! But also I read Japan can reach 55%😭

God that tax bill hurt.

1/4 LLMs solve research grade math problems but struggle with basic calculations. We bridge this gap by turning them to computers. We built a computer INSIDE a transformer that can run programs for millions of steps in seconds solving even the hardest Sudokus with 100% accuracy

What it feels like after saying 50 bps instead of half a percent