My latest first-author ChemRxiv preprint - and my first as a co-corresponding author - from my PhD external stay and postdoc work! chemrxiv.org/doi/full/10.26… Thanks to @laraialab and @hanzyduzit for a fruitful collaboration!
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Frederik Simonsen Bro
46 posts
Frederik Simonsen Bro
@BroSimonsen
Postdoctoral researcher in the Clementson group at Department of Chemistry at Lund University
Entrou em Şubat 2021
70 Seguindo30 Seguidores
Thank you to @ChemicalScience for featuring @laraialab's and my work, “Unifying principles for the design and evaluation of natural product-inspired compound collections” (doi.org/10.1039/D4SC08…), in their 2025 most popular organic synthesis articles collection!
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From the 1st of October, I will be joining the group of Assistant Professor Sebastian Clementson (@SebbeClement) in the Department Chemistry at Lund University working on the total synthesis of complex terpenoid natural products.
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My first perspective is out in @ChemicalScience!
@laraialab and I give our thoughts on the synthesis of natural product-inspired compounds. Check it out!
Luca Laraia@laraialab
Interested in natural product-inspired compounds? Check out our new perspective in @ChemicalScience: pubs.rsc.org/en/content/art… Deciding which synthesis strategy to pursue can be daunting, particularly as new strategies keep emerging! 1/2
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Frederik Simonsen Bro retweetou
Unifying principles for the design and evaluation of natural product-inspired compound collections | Chem. Sci. pubs.rsc.org/en/Content/Art…
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Frederik Simonsen Bro retweetou
Unifying principles for the design and evaluation of natural product-inspired compound collections pubs.rsc.org/en/Content/Art…
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I successfully defended my PhD on the 4th of November! Thanks to @laraialab and @hanzyduzit for great supervision and to @Adam_S_Nelson, @ThomasBPoulsen, and @KramerChemistry for nice discussions at the defence!
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Truly proud of this work! Huge thanks to @laraialab, @Laura_dta, @NienkeJDekker, @HoganBryceRoge1, @tomeveriss, Kaia, @TinoPetersson, and @MariuszKubus for their contribution!
Luca Laraia@laraialab
Second pre-print of the week!🥳This time @ChemRxiv we discover a funky 3D spirooxepinoindole core as a privileged scaffold for inhibiting sterol transporters! 1/n doi.org/10.26434/chemr…
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Frederik Simonsen Bro retweetou
NEW pre-print! Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters. Fantastic work by @Laura_dta with support from @HoganBryceRoge1, @NienkeJDekker, Anna and Nicolo! 1/n biorxiv.org/content/10.110…
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Frederik Simonsen Bro retweetou
Big day for the lab as our latest paper is out in Nature Chemical Biology @nchembio on identifying the oxybipins as new OSBP inhibitors, as well as their mechanism of action and therapeutic applications! nature.com/articles/s4158… 1/n
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Frederik Simonsen Bro retweetou
We found a rather promiscuous aKG enzyme that can desaturate or hydroxylate a number of monocyclic/bicyclic substrates and develop its synthetic application. I'm personally quite fond of the desymmetrization-azidation shown below.
chemrxiv.org/engage/chemrxi…
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Frederik Simonsen Bro retweetou
We verified the function of a C–S bond forming P450 in griseoviridin biosynthesis for the first time and developed a short chemoenzymatic synthesis of the natural product: chemrxiv.org/engage/chemrxi…
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Frederik Simonsen Bro retweetou
Delighted to take part in this @thiemechemistry cheminar! Dial in on May 29th to hear more about our work on natural product-inspired compound synthesis with different applications! cassyni.com/events/J1Mmjzc…
Rohit Bhatia@BhatiaRohit10
Check out seminar Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients presented by @laraialab and Dr. S.P.Swain and Dr. Gangarajula Sudhakar and @NilanjanaMajum4, chaired by @LahaJoydev 📅 Wednesday 29th May 2024 cassyni.com/events/J1Mmjzc…
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Huge congratulations to my colleague and good friend. Well deserved!
Joseph Hoock@HoockJoseph
I'm super happy and proud to share that today I won a prize for Best PhD in Medicinal Chemistry in Denmark. Grateful for my supervisor @laraialab and all collaborators I got to work with along the way. Excited to represent Denmark at the #EFMC-ISMC 2024 in Rome later this year.
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Frederik Simonsen Bro retweetou
New paper in Bioorg Med Chem on degraders of the sterol transport protein Aster-A! We use the pomalidomide core as a fluorescent handle to determine binary binding constants, develop competitive assays, determine cell permeability + degrade Aster-A! 1/n sciencedirect.com/science/articl…
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Very well deserved. A fantastic supervisor and a huge inspiration!
Luca Laraia@laraialab
It is an honor to be awarded the 2024 RSC Medicinal Chemistry Emerging Investigator Lectureship! Great recognition made possible by my fantastic group: @Laura_dta @HoockJoseph @tomeveriss @BroSimonsen @NienkeJDekker @HoganBryceRoge1 @mikkelkrell and more not on X!
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@BroSimonsen Great having you in the lab! Fingers crossed that we find more potent inhibitor(s) from your screen!
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I will travel back to Denmark today. Thank you to Assoc. Prof. Hans Renata @hanzyduzit and the whole Renata group for six great months at Rice University in Houston!
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