Fasan Lab

Delighted to share our paper just appeared in Chemical Science on the discovery of macrocyclic peptides targeted against an RNA motif from SARS-CoV-2! Congrats to Jake, Andrew, and Abhijith @UT_Dallas and great collab with Wedeking group @URochester_SMD pubs.rsc.org/en/content/art…

Honoring the exceptional women in the @FasanLab at @UT_Dallas whose insight, dedication, and curiosity elevate our work every day! Happy International Day of Women and Girls in Science to Anwita, Francesca, Michelle, Pamela, Ru, Shreya, Sophie, and Zoe! 🎉

A great visit by Prof. Yi Lu at UT Austin as our departmental seminar speaker this past week! We really enjoyed hearing about his group's exciting work in the design of artificial enzymes and DNA-based sensors for diagnostics. Inspiring science and great discussion!

Delighted to share our publication in @NatureComms on the computational design of generalist carbene transferases with tailored, stereodivergent selectivity! Great collab with Sagar Khare! Kudos to Zhuofan, Mary, and Xinkun and all other coauthors! nature.com/articles/s4146…

@FasanLab @UT_Dallas develops a new powerful method for skeletal editing of complex natural products at aliphatic C-H sites by combining site-selective and tunable enzymatic hydroxylation with chemical oxidation/ring expansion. Read on: • onlinelibrary.wiley.com/doi/10.1002/an…

Very grateful to Benjamin List and Kateryna Kryvous for selecting our paper on a photobiocatalytic strategy for C(sp3)-H acylation for a highlight in Synfacts! 🙏 🙏 thieme-connect.com/products/ejour…

Check out our paper just published in @angew_chem on a chemoenzymatic strategy for ‘skeletal editing’ of complex molecules with engineered P450s! Big congrats to John Bennett, Andrew Bortz, Zheyuan Wang, & Muhammed Fastheem for the excellent work! onlinelibrary.wiley.com/doi/10.1002/an…

Congratulations to @Yining_Wang_ in the @FasanLab at @UT_Dallas for passing his qualifying exam! He is now officially a PhD candidate! Way to go, Yining! 👏👏

📢📢Our lab has a #postdoc opening!! If you are interested in pursuing *exciting* research at the interface of biocatalysis, cellular signaling, structural biology, and computation chemistry, reach out to me at ambikab@umn.edu. Check out our recent work: bhagi-damodaran-lab.weebly.com/publications.h…

Kudos to our Clark summer research fellows Gianna Eckerle and Andy (Anh Triet) Tran for doing a great job at presenting their research projects at the SURP Symposium @UT_Dallas!

Check out our paper on stereoselective synthesis of halogenated cyclopropanes via biocatalytic cyclopropanation! Kudos to lab members Ron Adukure and Muhammed Fastheem and big thanks to our collab Tay Rosenthal, Matt Robinson & team at Corteva Agriscience! …mistry-europe.onlinelibrary.wiley.com/doi/full/10.10…

We are hiring! Multiple postdoctoral positions are available in our lab in the areas of biocatalysis, protein engineering/design, and peptide/protein therapeutics: jobs.utdallas.edu/postings/29784 Interested candidates should email the PI with CV and cover letter. Please spread the word!

Photobiocatalytic Enantioselective Benzylic C(sp3)–H Acylation Enabled by Thiamine-Dependent Enzymes via Intermolecular Hydrogen Atom Transfer | Journal of the American Chemical Society pubs.acs.org/doi/full/10.10…

On the International Day of Women and Girls in Science, a big shoutout to all the women in the @FasanLab @UTDallasChemBio for their outstanding contributions to our science! Go Aanu, Anwita, Elanor, Francesca, Hiram, Mary, Marriah, Michelle, Pamela, Ru, Shreya, and Yashika!🦾🎉

Congrats to Jadab @majhijadab , Saty, and Anwita @Anwita_Ch for their recent paper in @ACSCatalysis on a new biocatalytic strategy for the asymmetric synthesis of oxazolidinones via intramolecular C-H amination with engineered myoglobins! Great job! 🎉👏 pubs.acs.org/doi/full/10.10…

Happy to share our recent paper on the regiodivergent C(sp3)–H functionalization of indolines via enzymatic carbene transfer in @ChemCatalysis Big kudos to lead authors Bo Couture and Ru Cui for the excellent work!🎉 cell.com/chem-catalysis…

We are hiring! Our Department of Chemistry and Biochemistry at @UT_Dallas has two open-rank faculty positions in the areas of Biochemistry and Inorganic Chemistry, broadly defined. Come join a dynamic and vibrant department! jobs.utdallas.edu/postings/27645 jobs.utdallas.edu/postings/27649

Excited to see our recent paper on chemoenzymatic DOS using engineered P450 enzymes highlighted in Chemical & Engineering News! cen.acs.org/synthesis/medi… Many thanks to Brianna Barbu for the great cover article and to Robert Huigens for the enthusiastic comments on our work!

Delighted to share our latest work on a Chemoenzymatic Diversity-Oriented Synthesis strategy for generating complex, natural-product-like compounds with enzymes. Big 👏to the lead authors Andrew Bortz and John Bennett for this beautiful work!🎉sciencedirect.com/science/articl…

Great representation of the Fasan lab at #ACSFall2024 Postdoc Jadab Majhi @majhijadab & grad students Anwita Chattopadhyay @Anwita_Chand and Ron Adukure will present new biocatalytic strategies for the stereoselective synthesis of lactones, aminals, and halogenated cyclopropanes