Greninger Lab

Mpox continues to spread in many communities. Tecovirimat has activity against orthopoxviruses in vitro. In a phase 3 trial involving patients with acute mpox, tecovirimat showed no evidence of clinical activity. Full STOMP/A5418 trial results: https://nej.md/4rdlMA9

A new, rapid, point-of-care diagnostic lab test for hepatitis C could help thousands be cured, but adequate insurance reimbursement is vital, researchers @uwlabmedpath say. @GreningerLab @JClinMicro tinyurl.com/438xm9jk

New biorxiv on the discovery of an anellovirus genome integrated into an acute myeloid leukemia cell line that’s been used for 30+ years. The discovery informs blood cell tropism of anelloviruses and let us profile cancer systems biology data to inform anellovirus transcription.

1/ How has H5N1 affected this year’s flu season in Seattle? Despite ongoing outbreaks in birds & cattle nationally, we detected zero H5N1 cases in 675 influenza A-positive specimens tested at UW Medicine.

Just when you think you've dodged the latest round of colds at work or school, sniffles & sore throat begin. A new study @GreningerLab @uwlabmedpath @JIDJournal suggests a strategy rhinoviruses might be using to raise their chances of infecting people tinyurl.com/2rhr77zv

As U.S. syphilis cases surge, @uwlabmedpath researchers are determined to improve diagnostic tests for the infection. Untreated cases can cause severe harm. Grants @NIAIDNews @NIH awarded to @GreningerLab @MolMicro_Path & Salipante lab tinyurl.com/tsa6xh4m

Let’s go!! ⁦@GreningerLab⁩ kicking off the the afternoon session at #SCASM2024

Performance characteristics of highly automated HSV-1 and HSV-2 IgG testing medrxiv.org/cgi/content/sh… #medRxiv

Genomic epidemiology and evolution of rhinovirus in western Washington State, 2021-22 medrxiv.org/cgi/content/sh… #medRxiv

@SBtotheDub @washingtonpost Putting all that PHI in the photo on blast really gives me a lot of confidence in their informed opinions on laboratory testing regulation.

⁦@washingtonpost⁩ you might want to educate yourself on the test performance of tests that are actually approved by FDA. Spoiler alert - they’re not all awesome. Just as you’re talking about missed diagnoses & all… washingtonpost.com/opinions/2023/…

Within-host rhinovirus evolution in upper and lower respiratory tract highlights capsid variability and mutation-independent compartmentalization biorxiv.org/cgi/content/sh… #bioRxiv

Genomic epidemiology of Treponema pallidum and circulation of strains with diminished tprK antigen variation capability in Seattle, 2021-2022 biorxiv.org/cgi/content/sh… #bioRxiv

Evaluation and Clinical Validation of Monkeypox Virus Real-Time PCR Assays medrxiv.org/cgi/content/sh… #medRxiv

Genomic characterization of respiratory syncytial virus 2022-2023 outbreak in Washington State, USA medrxiv.org/cgi/content/sh… #medRxiv

Want to help lead operations behind groundbreaking #Virology research? Apply for the Laboratory Administration Manager position in the @UWVirology @GreningerLab today! tinyurl.com/3mhj52ky

@GreningerLab has a great opportunity available for a Research Scientist/Engineer 3!

@UWVirology is offering #monkeypoxtesting. You don't need to be a @UWMedicine patient to get it - your doctor can order it from us here: testguide.labmed.uw.edu/public/view/MP….

SGTF update from @UWVirology 12/18 We are now at >50% likely Omicron for samples from WA.

ICYMI: Watch the full video of yesterday's media briefing with public health leaders, including @trvrb, @DocJeffD, @SantiagoNeme and @GreningerLab, urging the public to prepare for a rapid surge in COVID-19 Omicron cases. bit.ly/3q6FFuY