Hornstein Lab

Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven 𝗡𝗢𝗩𝗔 (𝗡euronal 𝗢rganellomics 𝗩ision 𝗔tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology biorxiv.org/content/10.110…

@DaninoYehuda @rolls_asya @TelAvivUni Good luck Yehuda, you will be highly missed and we wish you much success in Rolls lab

Hi friends!😎 I'm excited to share that after 7 amazing yrs as a PhD student and postdoc at @HornsteinLab, I'm starting my next chapter as a formal postdoc in @rolls_asya's lab @TelAvivUni. I'll be exploring systems #Cancer #Neuroscience using diverse cool TC and mouse models🐁🦀

TDP-43 may play a role in neurodegenerative disorders such as #alzheimersdisease and #parkinsonsdisease, even in the absence of detectable aggregates. @UKDRI @Cambridge_Uni @WeizmannScience @EmoryMedicine ow.ly/thRc50X1sgM

@IgorUlitsky Huge congratulations! 🎉

Busy times ahead. I apologize in advance for potentially taking longer to respond to e-mails for a few years...

Wearable robot gives ALS patients a hand buff.ly/BTxGLnp #ALS #AmyotrophicLateralSclerosis #ALSDisease #ALSTreatment #ALSResearch

IsomiR Utility in ALS Prognostication medrxiv.org/cgi/content/sh… #medRxiv

Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's a dedicated organization to oversee the servers] openrxiv.org 1/n

Excited to share our preprint: "𝐎𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐨𝐦𝐢𝐜𝐬: 𝐀𝐈-𝐝𝐫𝐢𝐯𝐞𝐧 𝐝𝐞𝐞𝐩 𝐨𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐚𝐫 𝐩𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐢𝐧𝐠 𝐫𝐞𝐯𝐞𝐚𝐥𝐬 𝐧𝐨𝐯𝐞𝐥 𝐀𝐋𝐒 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬 𝐢𝐧 𝐡𝐮𝐦𝐚𝐧 𝐧𝐞𝐮𝐫𝐨𝐧𝐬"

Delighted to share new work from our lab: MultiPerturb-seq 🎛️❌📥📤 Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.

The pure joy in Gaza as Iranian missiles cover the sky above Tel Aviv.

At AAIC 2024, phospho-tau assays look ready for primary and secondary care. @lunduniversity @wustl @BannerAlzheimer ow.ly/QPzg50SV3Tp

@medrxivpreprint This work is based on a pre-clinical study from the lab, by PhD student Dr. Anna Emde in @EMBO: embopress.org/doi/full/10.15…, and was performed in close collaboration with Dr. Angela Genge from @TheNeuro_MNI who ran the clinical trial.

@medrxivpreprint Plasma and CSF throughout the entire treatment period of 30 days, supporting the use of microRNAs as a pharmacodynamic marker of target engagement. These results enocurage larger and longer trials to test Enoxacin efficacy in patients with #ALS.

A phase Ib/IIa study of Enoxacin in patients with ALS medrxiv.org/cgi/content/sh… #medRxiv

Interested in 3' UTR changes in scRNA-seq? Check out our: * CPA-Perturb-seq paper * UCSC Perturb-seq tracks (see who regulates your favorite 3’ UTR!) * Seurat extension for polyA site analysis (PASTA) * Deep neural perturbation network (APARENT-Perturb) cell.com/cell/fulltext/…

Birth of a neuron. Stem cell transforming into a brain cell: #neuroscience

Human brain anatomy: #neuroscience

My team is working with a substantial arsenal of ML algorithms, analyzing diverse human molecular data. The most intriguing work imaginable. We do science and study human brain diseases, but like a small startup. Come join us!

We're hiring! Biomedical Data Science Researcher to develop ML/AI tools and investigate molecular mechanisms underlying neurodegeneration. Position details and requirements: machinelearning.co.il/job/biomedical… CV to Eran.hornstein@weizmann.ac.il / Nancyy@weizmann.ac.il #jobopportunity