JoshGD

In some very real sense, Ozempic was invented in 1990. Pfizer ran the human trials and just never published them. They showed it lowered blood glucose in diabetics, slowed gastric emptying, and killed hunger; the same 3 things that make Ozempic work today. The joint venture agreement said internal data stayed internal, and that was that. Pfizer killed the program in 1991. The reasoning, as far as I can tell, was that nobody would ever want an injectable diabetes drug besides insulin. So, the license went back to the hospital in Boston that held the patents. Novo picked it up in 1992 and spent the next two decades building liraglutide, then semaglutide. It's insane that data sat in a filing cabinet for 30+ years. I only know this because Jeffrey Flier, one of the Harvard scientists in the room, finally wrote it up. He's in his late 70s and didn't want the history to die with him. This makes you wonder what else is in those filing cabinets. Ozempic could've existed 27 years ago.

Clavicular reveals his current daily drug protocol "Adderall 30mg a day dosed 10, 10 and 10. Last dose is variable depending on whether I'm streaming or want to go to bed early. Selegiline which is an MAO-B inhibitor, basically blocks your body from breaking down dopamine, that's a transdermal patch. Pregabalin to block excitatory neurotransmitters so I'm less anxious and can handle crowded spaces. And Baclofen which is a GABA-B agonist similar to the receptor alcohol hits since I'm quitting drinking."

Yes