Ken Wolfe Lab

#Pichia2022 @UCD_Conway @UCD_Research @UCDMedicine

They found that the thick cell wall of strains with an intact HOC1 gene is the reason that they're difficult to transform with DNA. They have engineered the hoc1 mutation into the OPENPichia platform strain. See Van Herpe et al (2022): biorxiv.org/content/10.110…

Our study of loci affecting secretion of a heterologous protein in Komagataella phaffii (Pichia pastoris) is published. It’s the first QTL study done in this biotech yeast species… journals.plos.org/plosbiology/ar…

ラガービール酵母の起源 irishtimes.com/science/2022/1… 下面発酵するラガー酵母は起源に不明な点があった。 2つの株があって、ひとつは10年ほど前にパタゴニアの木こぶに生息する微生物なのが発見。 今回、もうひとつの株を英国の土壌から発見。もともとヨーロッパに存在した微生物らしい

Delighted that our discovery of European lager yeast parent is covered by the New York Times nytimes.com/2022/12/07/sci…

First European isolates of the lager yeast parent Saccharomyces eubayanus found by University College Dublin undergraduate students @UCD_SBBS @UCD_Conway @ucdscience @ucdmicrosoc @NovaUCD @ucddublin @KenWolfeLab @TadhgOCroinin @drkevinbyrne @jmorrisseycork academic.oup.com/femsyr/article…

Our paper on the mysterious flip/flop inversion polymorphism in Saccharomyces species -- It's old but it's young! Congratulations Letal, and thanks @PLOSGenetics for efficient handling. journals.plos.org/plosgenetics/a…

@McMurraylab Today's one won't accept "clonal"!

😲

@yeastpi @HittingerLab @jmopacheco Fantastic day to publish this intriguing discovery ;)

This one has taken a while, great to see it out, and thanks to all our collaborators incl @HittingerLab. @jmopacheco

@rortiz_ESR @wc_ratcliff ACE2... My favourite gene... pubmed.ncbi.nlm.nih.gov/1986241/

X-mas themed(!?) Kluyver colloquium feat. @wc_ratcliff's snowflake yeasts @TNWTUDelft

Interested in a postdoctoral position studying Candida drug resistance, genomics and evolution, in Ireland? Apply by Jan 7th 2021 tinyurl.com/y3o29te7

When cloning experiments go wrong...

Maybe I'm taking this online lecturing too seriously... @UCD_Conway

Our preprint on giant GAL clusters in Torulaspora is just out on BioRxiv. Congrats to Anjan on this lockdown project.