Mathieu G

White guys liked rock, but it was pushed out by the industry in favour of rap, which is very obviously not for white guys. Streaming has broken the industry's ability to force music down your throat and rap is declining because of it

Dune has capitalized where Star Wars has faltered in recent years. It’s done this by staying focused on the higher level of “mythological” storytelling instead of modern political messaging. Myth is about portraying timeless patterns in our quest for meaning.

The placenta and mammary glands do not try to keep babies low in vitamin K. They store vitamin K and slowly leak it to the baby. They preferentially transport MK-4. They are trying to engineer the antithesis of the vitamin K shot. That antithesis is not vitamin K deficiency. It is slow accumulation over time instead of a rapid bolus dose. Why? My guess is that the babies do not have well developed detoxification systems, so the placenta and mammary glands try not to expose them to massive bolus doses of glutathione-depleting agents, so they don’t get, say, autism. Humans convert all forms of vitamin K to MK-4, which is the mammalian form of vitamin K that cannot be replaced by any other form. That process involves converting it to menadione, which has high toxicity and is detoxified using glutathione. The preferential transport of MK-4 across the placenta probably reflects an ability of the baby to accumulate MK-4 without futile conversion to menadione and back to MK-4, a process that has been verified to occur in adults mediated by intestinal tissue. Even high-dose MK-4 in this process generates menadione that leaves into the urine as a glutathione conjugate. But perhaps fetuses and infants are better able to accumulate the MK-4 without so much futile cycling. That would explain the preferential transfer from the mother. Nature does not want infants to be vitamin K deficient. Infants are born deficient in vitamin K because modern diets are deficient in it. Medicine solves this problem by doing the total opposite of what nature intended and giving the infant the massive bolus dose of vitamin K that the placenta and mammary glands were trying to defend against. They used to give menadione itself but this was so toxic to infants it was replaced by vitamin K1. But vitamin K1 in large blouses will generate considerable menadione. The solution is to obey the imperatives of the placenta and and mammary glands and operate within their parameters. That means mothers eating vitamin K-rich diets before, during, and after pregnancy.

It turns out that when you plow investment capital into house flipping instead of industrial machinery, your economy flatlines.

Another example of the fact that, unless you're willing to make life unbearable, reducing consumption is not the solution to climate change.

This is an expression of quite a widely-held pre-industrial view that trading was to be stigmatised. In the traditional agrarian imagination, traders were parasitic middlemen. They didn't create wealth, nor were they interested in honourably taking it by the sword.

4% of centenarians die from cancer. Before age 80, it's 25-40%. The people who live the longest are barely dying of the disease everyone fears most. A new @NatRevImmunol review found their immune cells tell the story. NK cells in centenarians keep young transcriptional signatures. RUNX3 stays on. Cytotoxicity stays high. Both normally fade by 70. Their bodies handle inflammation differently too. Same chronic inflammation as any aging person, but the NLRP3 inflammasome, the trigger for inflammatory disease, is suppressed. Mice without NLRP3 live 34% longer (males). 722,000 centenarians exist today. The immune pathways they've preserved are the same ones in active aging-disease trials. Survivorship bias is the obvious objection. The NLRP3 data from mouse models doesn't care.

@LP_LaPresse J'espère!

Accès à un médecin de famille | « C’est encore plus difficile pour les nouveaux arrivants » lapresse.ca/actualites/san…

The most fascinating part of the Odyssey to me is the Cretan Lie. When you think of the Odyssey, the first thing you picture is probably Odysseus’s run-ins with famous monsters. The Cyclopes, the Sirens, Scylla, Charybdis, etc. But there’s a reading of the Odyssey in which none of these events took place, and a far more historically intriguing sequence of events emerges. For one, we don’t actually ‘see’ the run-ins with the monsters take place in the poem. Instead, these details all come from Odysseus’s own narration to the Phaeacians. They’re part of the story he tells them of his travels to convince them to charter a fleet to send him back home to Ithaca. The problem is, Odysseus is a liar. He lies constantly, any time he pops up in Greek mythology. In fact, in the Odyssey he tells many different people many different versions of what he did after Troy. And why would he tell the Phaeacians the truth? He wouldn’t, of course. He would tell them whatever he thought they wanted to hear. To me, the most intriguing version of events he tells is to his loyal swine herd. While still in disguise pretending to be a Cretan, Odysseus says that after the sacking of Troy, he led his men on an expedition against the Egyptians. But his expedition failed. His men were all killed or enslaved by the Egyptians. But he threw himself at the Pharaoh’s feet and begged for mercy. He received it, and spent 7 years in Egypt, where he amassed great riches, before being tricked and nearly sold into slavery in Phoenicia, but then surviving a shipwreck and making his way back to Ithaca. We know the Trojan War would’ve taken place during the same period that the Sea People were sacking their way down the coast of Anatolia (where Troy was) to Egypt, where Ramses III ultimately defeats them. This matches up perfectly with Odysseus’s ‘lie.’ I like to think that Odysseus saved the most honest version of his travels for his most loyal servant (though still cloaked in a lie, as Odysseus’s stories always are). And that Homer has preserved more about the Bronze Age collapse than we’ve ever given him credit for.

We warned scientists not to squander people’s trust. Investigate the lab leak Don’t overclaim for vaccines Don’t demand lockdowns Don’t worship models Don’t be dogmatic Encourage debate They have only themselves to blame.

This meme is going to turn into reality

Aged mice received ONE peptide — FOXO4-DRI — for 3 weeks. Fur grew back. Kidneys healed. Fitness returned. The aging REVERSED. (PMID: 28340339 — published in Cell) Right now there are MILLIONS of dead cells rotting inside your body. They can’t divide. They can’t repair. They REFUSE to die. They just sit there POISONING every tissue around them. Scientists call them zombie cells. The single biggest driver of aging ever discovered. → joints rotting with inflammation → skin collapsing as collagen disappears → wounds taking weeks instead of days → testosterone crashing year after year → energy vanishing no matter what you try Your doctor calls this “getting older.” It’s not. FOXO4-DRI is a synthetic peptide your body can’t break down. It does ONE thing. Zombie cells survive by TRAPPING p53 — your body’s kill switch. FOXO4-DRI frees it. The zombie cell self-destructs. Healthy cells don’t use this trick. Untouched. Every day you wait, more zombie cells accumulate. More tissue dies. Your body has a self-destruct button for broken cells. Age jammed it. FOXO4-DRI unjams it. The studies are below.

@LP_LaPresse Il n'y a pas assez de Blancs pour faire vivre tout le monde

Afrique du Sud | Flambée de violence contre les migrants lapresse.ca/international/…

Remind myself of the role reversal often.

A ten strike law preventing people from leaving prison after that many violent crime convictions would reduce period violent crime by 20% Five strikes would cut violent crime by 40% Three strikes would halve violent crime Two strikes would remove ~two-thirds of violent crime

Thank you Germany 🇩🇪and Britain 🇬🇧 for sacrificing your economies to save the planet. China appreciates you exporting your manufacturing to provide jobs for their citizens.

- Ethiopian comes on a study visa - A "minor traffic infraction" in Calgary sends him into road rage - Pulls a loaded Glock on the other driver - Probably won't be deported though because Ethiopia is dangerous - So instead Ethiopian criminals can stay and make Canada dangerous?

The polls probably aren't wrong. Boomers, women, and gimmigrants love the Liberal Party, because it transfers wealth and opportunity to them at the expense of the young white Canadian men who actually generate every cent of value in the country. It's a coalition of parasites and the parasites are absolutely in control. That's half the story. The other half is that the Conservative Party is as inspiring as soggy bread. It stands for nothing. Its remaining MPs (the ones who haven't crossed the floor to the Liberal Party) are a foul mixture of cynical opportunists, ethnic grifters, and spineless moral cowards. Its sole purpose is to suck up all of the oxygen in the space for organized political opposition, thereby preventing any effective opposition to the Laurentian program of systematic national suicide.

@globeandmail Just replace them with AI already!

Telus using AI to alter the accents of customer-service agents theglobeandmail.com/business/artic…

"We know you hate this, but we hate you, so we're doing it anyway."