Jonathan Schertzer (SchertzerLab)

Selective targeting of endothelial and perivascular angiocrine ROCK2 treats liver fibrosis cell.com/cell/fulltext/…

Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma cell.com/cell-host-micr…

TRIPping anti-tumour immunity through lactylation dlvr.it/TRHR2b

Preprint: CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation biorxiv.org/content/10.648…

Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease cell.com/cell-metabolis…

Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity dlvr.it/TR7qyl

Insulin and adipocyte IRF4 promote fat retention over muscle preservation during intermittent fasting in obesity cell.com/cell-reports/f…

New! Online now: Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis dlvr.it/TR6mSR

Hepatic adaptation to chronic metabolic stress primes tumorigenesis: Cell cell.com/cell/fulltext/…

In humans nighttime metabolic dysfunction is a hallmark of #MASLD with multiple pathogenic pathways upregulated at night, including hepatic and peripheral insulin resistance, DNL, and systemic NEFA exposure cell.com/cell-metabolis… #circadian

It was a great pleasure to meet @richroll and discuss nutrition and metabolism science on the @RichRollPodcast!

Great time at the #NeurIPS2025, especially the chance to discuss our collaborative work with the @SchertzerLab and @Ali_Etemad1 and to connect with AI experts pushing time-series methods for health. I really enjoyed catching up with friends and colleagues: @Zjahed, @JWangnano

Previously shared: Let’s GIV a NOD(2) to gut homeostasis Here, Pradipta Ghosh & team @UCSanDiego find a critical interaction between GIV and NOD2 in gut macrophages, revealing their importance in maintaining gut health and preventing inflammatory bowel diseases (#IBD): doi.org/10.1172/JCI190… The TEM images show phagolysosomal fusion events in infected macrophages from WT mice but not those from those lacking GIV.

T cell cholesterol transport links intestinal immune responses to dietary lipid absorption science.org/doi/10.1126/sc…

Inflammation is a key driver of the pathophysiology of cardiometabolic disorders #obesity #T2D and new metabolic medicines based on GLP-1 action exert their magic in part by reducing inflammation. A new review from Professor Donath summarizes the field sciencedirect.com/science/articl…

A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals nature.com/articles/s4225…

Structure of gut microbial glycolipid modulates host inflammatory response cell.com/cell/abstract/…

Portal vein-enriched metabolites as intermediate regulators of the gut microbiome in insulin resistance cell.com/cell-metabolis…

D-enantiomers nature.com/articles/s4225…

Quantifying the varying harvest of fermentation products from the human gut microbiota cell.com/cell/fulltext/…