Frankel Lab, Imperial College London

Great visit to Tokyo University. Thank you Hideaki and Chiho for wonderful hospitality.

Thank you, Gadi ⁦@TheFrankelLab⁩, for visiting us in Gifu and for the wonderful talk with many inspiring topics! We totally enjoyed your lecture and the pleasant time over dinner and the Ukai cruise with you❣️

We are happy to share our new preprint characterising production of the conserved polysaccharide PNAG, a potential vaccine target produced by many pathogens, in #Klebsiella pneumoniae during infection. Congratulations to everyone involved,especially Jonny! biorxiv.org/content/10.110…

We are happy to share our recent results on conjugation surface exclusion with a chromosomal twist. Must mention Chloe’s and Sophia’s incredible contributions. Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT biorxiv.org/content/10.110…

New paper from the lab now published @NatureComms We show that NETs drive immunopathology in exacerbated #COPD. Work led by the talented @OrestisKats (now moved onto pastures new) with help from our friends @ProfJDChalmers group. nature.com/articles/s4146…

Counterintuitively, induction of hyper gut inflammation restores neutrophil migration and infection resolution. Big thank you to everyone involved! @CBRB_Imperial @ImperialSci @ImperialMDR

We are happy to share our recent publication linking severe infectious colitis with reduced migration of neutrophils to the infection site, leading to their accumulation in the submucosa where they undergo NETosis causing tissue damage: sciencedirect.com/science/articl…

Global, regional, and national incidence and mortality burden of non-C... sciencedirect.com/science/articl…

Subset of absorptive colonic epithelial cells elicit MHCII-dependent help from IL-22+ T cells to orchestrate regional immune protection against Citrobacter in the intestine @Nature @cgarrettwilson Weaver & Zindl nature.com/articles/s4158…

Complement in breast milk modifies offspring gut microbiota to promote... sciencedirect.com/science/articl…

How does Salmonella infection become persistent? We are so proud to share our publication in @cellhostmicrobe Congratulations to Alex, Bar, Jonathan, Ashlee and all the coauthors. That was an amazing journey with @sheba_medical and @broadinstitute sciencedirect.com/science/articl…

Excellent news for @PharmaT3 and for the whole field of therapeutic synthetic bacteria ! German pharma company acquires University of Basel start-up for 450 million Swiss francs | University of Basel unibas.ch/en/News-Events…

New publication from the TacC Lab in collaboration with the Erhardt Lab. A long-awaited proof of DNA transfer via the extended conjugation pilus. pnas.org/doi/10.1073/pn…

Functional features of KPC-109, a novel 270-loop KPC-3 mutant mediatin... sciencedirect.com/science/articl…

Bacterial pathogens deliver water- and solute-permeable channels to plant cells pubmed.ncbi.nlm.nih.gov/37704725/

🦠 Research from @CBRB_Imperial shows that antibiotics promote the growth of antibiotic-resistant bacteria in the gut. The study could lead to better patient risk assessment and treatments to help combat antibiotic-resistant bacteria. ⤵️ imperial.ac.uk/news/247213/an…

Proud to share our latest discovery: Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly A new concept in antiphage immunity, and a mechanism for ISG15-like antiviral defnese in bacteria. Big congrats to talented @Jens_Hoer! A 🧵 biorxiv.org/content/10.110…

Very happy to share our review and view on bacterial conjugation Plasmids pick a bacterial partner before committing to conjugation academic.oup.com/nar/article/do…

Huge congratulations for this great story @BenWiggins_093, @cschieri and everyone else that contributed! Check out the article (and thread) if you want to know more about the importance of endothelial cells in maintaining gut health 🦠🥦🧍

Thanks to @gileadamit @TheEconomist for wading into the world of SaPIs and phages! Making science accessible to the public is tough work. I can barely explain it to other scientists! Tiny hitchhikers on viruses could promote resistance to antibiotics economist.com/science-and-te…