Tyler Pitre, MD PhD🇨🇦

🚨 Excited to share our new paper in @LancetRespirMed 🚨 Our systematic review & network meta-analysis compares preoxygenation strategies for critically ill patients needing intubation. NIPPV tops HFNC & facemask in reducing hypoxaemia. 🔍 Study Highlights • Systematic review & network meta-analysis of 15 RCTs (n=3420) • Compared HFNC, NIPPV, and facemask oxygen for preoxygenation • NIPPV likely best at reducing hypoxaemia during intubation   – vs HFNC: RR 0.73 (moderate certainty)   – vs facemask: RR 0.51 (high certainty) • HFNC better than facemask: RR 0.69 (high certainty) • No strategy improved first-attempt intubation success • NIPPV may reduce serious adverse events vs HFNC/facemask • No clear mortality difference between methods • Data used to inform upcoming international airway guidelines 🧠 Implications: NIPPV may be preferred in high-risk or critically ill patients; findings support evidence-based guideline updates kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2… @UofT_DoM @MacDeptMed @Bram_Rochwerg @DenaZera @HEI_mcmaster

"A significant fraction of the reporters covering the FDA and pharmaceutical industry have developed, over years of access journalism, a set of relationships and sympathies that align them more closely with the companies they cover than with the regulatory mission"

@juliomayol If I want to hurt myself, I'd do it without that. Thanks though.

Is peer review changing? Try #Reviewer2 on any open-access paper. claude.ai/public/artifac…

If you now want to switch off ChatGPT (for any reason 👀), here's your 15-minute migration guide. No, you won't lose everything. No, it's not hard. And honestly? Starting fresh might be the best part.🧵

@RodKahx You're as brainwashed as Trump supporters.

Carney is merely a realist. It's refreshing.

The signs are up @MarkJCarney

How many times will the USA drag the rest of the world into war? In my lifetime, there has been the Iraq war, the disaster in Libya, and Syria. Now we are being led to accept the atrocities in Gaza and blindfully accept an illegal war in Iran. The United States is unacceptable and no better than Russia in its wanton aggression. #Iran

@ryangrim Very embarrassing...

Mark Carney, who awed the world with his speech about the rules-based order and his opposition to American belligerence, says he supports this new attack on Iran

@sama I will be unsucribing to ChatGPT. Thank you for your attention to this matter @sama

Tonight, we reached an agreement with the Department of War to deploy our models in their classified network. In all of our interactions, the DoW displayed a deep respect for safety and a desire to partner to achieve the best possible outcome. AI safety and wide distribution of benefits are the core of our mission. Two of our most important safety principles are prohibitions on domestic mass surveillance and human responsibility for the use of force, including for autonomous weapon systems. The DoW agrees with these principles, reflects them in law and policy, and we put them into our agreement. We also will build technical safeguards to ensure our models behave as they should, which the DoW also wanted. We will deploy FDEs to help with our models and to ensure their safety, we will deploy on cloud networks only. We are asking the DoW to offer these same terms to all AI companies, which in our opinion we think everyone should be willing to accept. We have expressed our strong desire to see things de-escalate away from legal and governmental actions and towards reasonable agreements. We remain committed to serve all of humanity as best we can. The world is a complicated, messy, and sometimes dangerous place.

@BrandonLuuMD lol I’d be out of there immediately. What a rediculous attack on their doctors.

Quebec's approach to the physician shortage: 1) Force compensation reform 2) Fine doctors up to $20,000/day for "concerted action" 3) Fine medical associations up to $500,000/day for organizing opposition

@BrandonLuuMD Observational data shouldn’t sway you either way, because it’s largely all garbage.

Observational data used to suggest light alcohol use was protective of dementia New data shows the opposite: dementia risk increases with every drink There is no safe amount of alcohol

@MarkJCarney Very weak and pathetic response.

Iran’s nuclear programme is a grave threat to international security, and Canada has been consistently clear that Iran can never be allowed to develop a nuclear weapon.     While U.S. military action taken last night was designed to alleviate that threat, the situation in the Middle East remains highly volatile. Stability in the region is a priority.   Canada calls on parties to return immediately to the negotiating table and reach a diplomatic solution to end this crisis. As G7 leaders agreed in Kananaskis, the resolution of the Iranian crisis should lead to a broader de-escalation of hostilities in the Middle East, including a ceasefire in Gaza.

NEW @bmj_latest research by @DenaZera and colleagues reviews evidence from randomised trials assessing the effectiveness of strategies to deprescribe benzodiazepines and closely related sedative hypnotics bmj.com/content/389/bm…

Excited to share our new paper in Intensive Care Medicine demonstrating the effectiveness of corticosteroids in community acquired pneumonia including new data from subgroups in ARDS and sepsis trials as well as the new REMAP-CAP trial. rdcu.be/ekQKn @Bram_Rochwerg @EllenPauley @HEI_mcmaster @UofT_DoM @MacDeptMed link.springer.com/article/10.100…

This is what democracy looks like. This is what's supposed to happen when the debate is over. This is what makes Canada great. 🇨🇦🇨🇦🇨🇦

@DefensePolitics Your political punditry is awful. Stick to maps.

Ireland's Minister for Trade and Foreign Affairs deeply regret the blanket tariff on EU - claiming it could have significant effect on Ireland.... ... I have to say.... Quitting the EU is a solution. UK only have 10%. #JustSaying

@piersmorgan Wow how insightful…

PREDICTION: President Trump’s global tariff war is either going to be a spectacular success or a total disaster. I have no clue which.

Canadians sighing with relief for not being on this list should remember we still have border tariffs of 25%, auto tariffs of 25% and steel and aluminum tariffs of 25%. Like dodging a bullet into the path of a tank.

@ParikPatelCFA lol 😂 don’t give him ideas 💡

BREAKING 🚨: Trump imposes tariffs on exporting to PDF

Preoxygenation strategies for intubation of patients who are critically ill: a systematic review and network meta-analysis of randomised trials CCR Journal Watch - tracking the critical care literature daily criticalcarereviews.com/latest-evidenc…