Axel Janssen ретвитнул
OUT NOW! 👇🏼We built a make-or-break Prime editing tool—have a read to discover how it’s changing the way we do genomic engineering.
nature.com/articles/s4146…
@JWVeening @AxelJans & all others authors! 👏🏻
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Axel Janssen
728 posts
Axel Janssen
@AxelJans
Postdoctoral researcher in the @DMF at @UNIL. Opinions my own. Mastodon: @[email protected]. Bluesky: https://t.co/X8jHCpfdTw
Lausanne, Switzerland Присоединился Ekim 2010
494 Подписки283 Подписчики
Axel Janssen ретвитнул
Checkout @Bevika2 preprint! She used CRISPRi-seq to determine antibiotic-stress signatures, specifically of pneumococci treated with fluoroquinolone antibiotics. It's a really powerful approach revealing a surprising antibiotic combination therapy. 1/9 biorxiv.org/content/10.110…
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Again, thanks to all co-authors for their work on this as well, and other Veening lab members for their continued feedback and bug reports.
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We have now also added the ability to view pair-wise genome alignments to PneumoBrowse2.
Find this option in the "Linear Synteny" or "Dotplot" alignments views (bottom), or in separate data tracks (per genome).
Thanks for the excellent reviewer comments on this.
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Do you use D39V, TIGR4, EF3030, BHN418, or another pneumococcal strain in your research? Easily browse their genome on PneumoBrowse 2 pneumobrowse2.veeninglab.com! Now out in shiny PDF in Nucleic Acids Research!
Do you have any feedback? Please let us know!
academic.oup.com/nar/advance-ar…
Jan-Willem Veening@JWVeening
Happy to announce PneumoBrowse 2! Access it here: pneumobrowse2.veeninglab.com and read the preprint here: biorxiv.org/content/10.110…
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Axel Janssen ретвитнул
You are looking for a PostDoc position or know someone who is? We are looking for someone to join our team at @ETH_en Zürich for a project on phage-host interactions of Pseudomonas aeruginosa 🦠🧬👇🏼
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Axel Janssen ретвитнул
New job opportunity 📢
Associate professor, immunity/inflammation/infection (defined broadly) especially welcome
Come and join a great community of supportive colleagues!
Deadline 25 October, please spread the word
path.ox.ac.uk/vacancy/associ…
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Axel Janssen ретвитнул
We are delighted to announce we @NCCR_AntiResist are funding a four-year PhD position with the Boeck lab in Infection Biology, focusing on pulmonary Pseudomonas aeruginosa infections using genomic and large-scale wet lab technologies.
👉Read more: nccr-antiresist.ch/join-us/
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@JulDenereaz If you are interested in pneumococcal strains D39V, EF3030, BHN418, TIGR4, or one of the PMEN reference strains, you can check out the genomes interactively in PneumoBrowse 2!
Go straight to PneumoBrowse 2: pneumobrowse2.veeninglab.com
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I definitely recommend to check out our work on make-or-break prime editing, but also our newest edition of PneumoBrowse! But don't sleep on @JulDenereaz's great dual CRISPRi-Seq work!
(Spoiler: I am on the author list of the first 2 papers)
Jan-Willem Veening@JWVeening
ICYMI: 3 new preprints from the lab: 1) Make-or-Break Prime editing: the most elegant bacterial genome editing tech to date 2) PneumoBrowse2.0: Revamped pneumococcal genome browser 3) Dual CRISPRi-seq: One of the most comprehensive genetic interaction study in bacteria ever
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Axel Janssen ретвитнул
2) PneumoBrowse2.0: Revamped pneumococcal genome browser
biorxiv.org/content/10.110…
Axel Janssen ретвитнул
1) Make-or-Break Prime editing: the most elegant bacterial genome editing tech to date
biorxiv.org/content/10.110…
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Axel Janssen ретвитнул
ICYMI: 3 new preprints from the lab:
1) Make-or-Break Prime editing: the most elegant bacterial genome editing tech to date
2) PneumoBrowse2.0: Revamped pneumococcal genome browser
3) Dual CRISPRi-seq: One of the most comprehensive genetic interaction study in bacteria ever
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Axel Janssen ретвитнул
Genome-wide dual CRISPRi-seq! Knocking down every gene with every other gene in the pneumococcus, identifying > 4000 genetic interactions (GIs), most of which have never been reported. biorxiv.org/content/10.110…
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Axel Janssen ретвитнул
Dual CRISPRi-Seq for genome-wide genetic interaction studies identifies key genes involved in the pneumococcal cell cycle biorxiv.org/cgi/content/sh… #biorxiv_micrbio
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Axel Janssen ретвитнул
Introducing Bacttle! A board game targeting players in primary school that showcases the life of microbes. From basic concepts of environmental microbiology to motility & biofilm formation, the game aims to increase knowledge about bacteria. #JMBE: asm.social/20z
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Axel Janssen ретвитнул
PneumoBrowse 2 is freely available on pneumobrowse2.veeninglab.com. Many thanks to the entire lab for keeping track of updates and literature and specifically @AxelJans @PaddyGibson2 @afonsbravo @vincentdebakker @JelleSlager for putting it all together and @doranpauka for IT support!
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Axel Janssen ретвитнул
Happy to announce PneumoBrowse 2! Access it here: pneumobrowse2.veeninglab.com and read the preprint here:
biorxiv.org/content/10.110…
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Axel Janssen ретвитнул
We're looking for an enthusiastic experimentalist PhD student to join our interdisciplinary group interested in the ecology & evolution of microbial communities unil.ch/mitrilab. Apply tinyurl.com/mu5swnk8 before Aug 31! Bonus: Lausanne is a beautiful place to live!
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