Gabriel Doctor

@CartlandDavid 1. Adverse events are any “event” reported by patient /doc - not proven to be related. (Eg “diarrhoea” in the days after vax). A smal fraction of these are causal and serious. 2. 158k reactions reported in 40k people. A small % of milllions of people vaxed.

This is mind blowing! Pfizer whistleblower releases internal documents showing they had received over 158,000 adverse reaction reports within 2 months of it's release.

“These types of insights – the ones that you can only really get from large cohorts - are really valuable” ... @DannyGale_1 discusses how RaDaR can support projects like PARASOL with longitudinal data. Listen to the full episode of #KidneyCompass now: hcplive.com/view/kidney-co…

Congratulations Omid @OAlavijeh ! I’m delighted to see you win this very well deserved award and excited about what will come next in your career!

As always thanks to @RenalGenomics @drmelaniechan @GTDoctor @DannyGale_1 and others for your support, @The_MRC for funding the work, and to the patients and families who have taken part in #100GKP @GenomicsEngland. Link to the pre-print below: medrxiv.org/content/10.110…

PhD opportunity for a clinician in my lab! Co-supervised by @NeuroMikeD crick.ac.uk/careers-study/…

We are heartbroken to announce that Prof (Stephen) Ben Walsh, died peacefully on 30th Sept while surrounded by family & friends. Both his family & @RenalUCL are raising funds to find a way to honour his memory and achievements. More info below: justgiving.com/page/in-memory… Ben's passion for science & medicine was an integral part of who he was. And after self-diagnosing with lung cancer 18 months ago, he decided keep his condition private to protect his clinical and academic work. Remarkably Ben continued to work throughout his illness, right to the very end, ensuring that his students, colleagues and patients were taken care of, and that all he had built would continue on. There are no words to really express the profound sadness we feel, the loss of a dear friend, colleague and mentor. He will leave a very large hole in our lives and he will not be forgotten. Details of funeral/memorial services will be made available in due course. We're also requesting anyone with pictures or videos of Ben to upload these to the Google Photos or Dropbox links below. We've also attached a link to a Google Doc for messages of condolence you may wish to leave for the family. Google Photos: photos.app.goo.gl/PBQUdUHc6f1fys… DropBox: dropbox.com/request/6tiIZ7… Google Doc for condolences: docs.google.com/document/d/1wG… Donation Page for Memorial Fund: justgiving.com/page/in-memory…

Now open! Incl an IgA nephropathy project in my group. We will fill in gaps in pathogenesis, aiming to better match new/upcoming drugs to each patient, and to find angles for next generation of treatments to remedy. Please get in touch if you want more info.

The primary piece from my PhD on cystic kidney disease is out today in @jclinicalinvest! jci.org/articles/view/… The full thread discussing the paper is linked in the tweet below. As always many thanks to @The_MRC and @GenomicsEngland, @RenalGenomics and many more!

IL-6 signalling in inflammation affects many pathways. Modulation is associated with adverse events including white cell depletion and gastric perforation. 2 randomised trials in carefully selected patients are ongoing.

Most report are case series of desensitsation or cABMR treatment. Some centres report successful use for cABMR (standard care can be inadequate), but the only (small) matched case control study showed no difference. A small RCT for subclinical inflammation showed resolution.

Delighted to see this published doi.org/10.3390/jcm131…. With colleagues at @GSTTnhsrenal unit @cnuteducation Caroline Dudreuilh @cdudreuilh Ran Perera and Prof Anthony Dorling. Case report and review of tocilizumab (TCZ) and IL-6 pathway modulation in kidney transplantation.

Fantastic work @drmelaniechan - I can’t wait to see you answer these mysteries over the next few years!

New grant success 🎉 Dr Gabriel Doctor from @UCL has received a Kidney Research UK clinical training fellowship award of £300,000 to investigate the genetic causes of idiopathic nephrotic syndrome (INS). Read more below 👇 bit.ly/48Y6I03

Fantastic work by group members Katie Wong and David Pitcher working at @RenalRadar, with many others in the U.K. renal community. Outcomes for 27285 patients in 28 rare disease group, showing outsize contribution to prevalence of endstage kidney disease tinyurl.com/yvybsvx2

Beating #KidneyFailure needs #RareDisease cures. @RenalRaDaR data out today reveals a staggering 28x higher 5-year kidney failure risk in 28k people with #RareKidney diseases c/w 2.8 million with #CKD. Trajectories in 28 diseases included for reference tinyurl.com/yvybsvx2

The use of the phrase “ancestry-specific variant” is increasing, particularly to describe rare Single-nucleotide variants (SNVs). But these alleles are not ancestry-specific. They have not yet been found elsewhere, but they will be. 1/n

OK Go recorded this music video shot in near-zero gravity aboard a parabolic airliner without using CGI, wires or green screen: the video was cut from one take filmed over 45 minutes of continuous flight.

Deeply disturbed and saddened by news of the death of Alexei Navalny. Putin fears nothing more than dissent from his own people. A grim reminder of what Putin and his regime are all about. Let's unite in our fight to safeguard the freedom and safety of those who dare to stand up against autocracy.