Michiels lab

🩸 From RNA-limited samples to the identification relative abundance of RNA modifications in a short time - The EpiPlex assay, presented at #RNGS25 by Gudrun Stengel of Alida biosciences, makes use of proximity barcoding and engineered binders to specifically detect RNA mods. 🧬

Our conference stress melted away after an evening filled with a choco-lot of fun at the #RNGS25 social activity at @ChocolateNatio4.

"Plants don't have specialized immune cells, but individual plant cells can flexibly turn into immune hotspots" - 🌱 @nobolly presented at #RNGS25 on combining single cell multiome data & spatial transcriptomics to study the genetic regulation of plant-microbe interactions.🧬🦠

Nanopore sequencing enables detection of DNA methylation profiles! 🧬 Mathilde Geysens showcased a powerful approach to identify episignatures of developmental disorders, offering deeper insights into methylation patterns and paving the way for future diagnostics. #RNGS25

Great poster by @genewizeu showing all the complex multiomics info that can be gathered from a single patient sample.🧬They also explored the single cell transcriptome on FFPE tumor tissues & show that better insights in human health can be obtained from minimal samples. #RNGS25

At #RNGS25, Kirsten Bos took us back in time by looking into the ancient DNA of infectious diseases.🦠 Her talk highlights the importance of genomics to trace the evolution and spread of syphilis, revealing crucial insights to improve our understanding of contemporary diseases.

Nice overview of the @illumina technology roadmap by Jason Betley at #RNGS25. In his talk, he provided a great perspective on the different Illumina platforms and more specifically on their various innovative and easy-to-use sequencing assays. 🧬

"Biology is dynamic like a river, you cannot step into the same water twice." Great talk on unlocking high dimensional biology using evolved next-generation sequencing by @MollyminHe of @ElemBio this morning at #RNGS25.

Fun & adventurous talk on microbial dark matter at #RNGS25. @jimmysaw presented on harnessing long-read sequencing to enable reconstruction of geothermal bacterial genomes. His groundbreaking work brings us one step closer to uncovering biological functions in early life on Earth

I am very excited to be reporting on the groundbreaking talks at #RNGS25, together with @vanshikabidhan & @Sara_Alidadiani. Follow me on Bluesky (@michielslab.bsky.social), LinkedIn (Lieze Agten) and here on X to keep track of this revolutionizing conference! @VIBTrainConf

🚨The final deadline to register for #RNGS25 is this Wednesday, March 5th!🚨 Make sure to register - You don’t want to miss out on Prof. Thienpont (@bernthie)'s fascinating talk on improving patient care by using cell-free DNA methylome analysis. 🧬 vibconferences.be/events/revolut…

🚨Don’t miss #RNGS25!🚨 🧬Prof. Jimmy Saw, who contributed to the discovery of the fascinating Asgard archaea, will explore how long-read sequencing unlocks microbial dark matter in geothermal habitats.🦠 📆Early bird registration deadline is February 5! vibconferences.be/events/revolut…

Proud to present our latest model of aggregation-induced dormancy, published in #NatureComms @LiselotDW rdcu.be/d7EcI

🧬Join the #RNGS25 conference in Antwerp from 19-21 March to hear more about the exciting work of Dr. Tatsuya Nobori (@nobolly) on the single-cell and spatial dissection of plant-microbe interactions. 🌱🦠 📆Abstract deadline approaching: 15 January📆 vibconferences.be/events/revolut…

🧥 Bacteria have a protective coat of lipopolysaccharides. New work by @LabMichiels, @LiselotDW, Wim Versées, and colleagues highlights the crucial role of the protein ObgE, which could lead to new treatments for infections. 👉 vibbio.tech/3CyY79D @VIB_microbes @structbiolbxl

Thrilled to have contributed to @LiselotDW's exciting work on the role of ObgE in LPS synthesis nature.com/articles/s4146…

In this editor’s choice, Vercauteren et al. comprehensively reviews mechanism, implementation, potential, strengths and weaknesses of #CRISPR interference (#CRISPRi), a gene perturbation technique. #FEMSMicrobiolRev @LabMichiels academic.oup.com/femsre/article…

Check out our latest work on antibiotic resistance mechanisms in nontuberculous mycobacteria academic.oup.com/jambio/article…

Check out our latest review on CRISPR-based approaches for high-throughput genomics academic.oup.com/femsre/article…

Throwback to our @VIB_microbes retreat with @RaesLab, @LabMichiels, @Masschelein_Lab, @SibylleVonesch and @KevinVerstrepen's team at the Antwerp Zoo!