Lisa Singer

The Astounding Physics of N95 Masks youtu.be/eAdanPfQdCA?si… via @YouTube

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Wir veranstalten ein Gewinnspiel zum 10. Jubiläum von #FFXIV Heavensward! ➡️ Besucht sqex.to/Bh9Yc 🔔 Folgt, repostet und besucht #FFXIV-Seiten 🎁 Erhaltet die Chance, den Silberanhänger zu gewinnen! Zu den vollständigen Regeln geht es hier 📜 sqex.to/IfhpP

We're celebrating Heavensward's 10th anniversary with a sweepstakes! ➡️ Visit sqex.to/Bh9Yc 🔔 Follow, repost, or view various #FFXIV pages 🎁 Chance to win a silver pendant! For full terms and conditions, please see the official rules at sqex.to/VoQDt.

#BOYCOTTUSA there are lots of great Canadian brand to choose.

🚨 It’s Tariff Day — Here is how you can replace American Brands with 🇨🇦Canadian Brands. Save the image and Take this shopping 🛒 #shoplocal #ShopWisely #buycanadian #shopCanadian #ilovecanada

Trump's rambling like a diaper-filled lunatic today about not needing Canada's O&G, Lumber, and Potash: - 90% of US farmers use Canadian Potash - 60% O&G - 85% softwood lumber No problem @realDonaldTrump. Canada has trade deals with 199 other countries.

“That’s when they suspended the constitution. They said it would be temporary. There wasn’t any rioting in the streets. People stayed home, watching their televisions, looking for direction. There wasn’t even an enemy you could put a finger on.” - Margaret Atwood, Handmaids Tale

🚨1/ 🇺🇸 vs 🇨🇦: Let’s comparison of key statistics that reflect the quality of life in both countries in the face of @realDonaldTrump’s HILARIOUS PR campaign against Canada: 🧵#Stats #QualityOfLife

My own dog Hank is huge. People cross the street when they see him in fear. He's not good around other male dogs. However when it comes to sick dogs in my house who need the most serious care...Nurse Hank steps up 🥰🙏 Alba is his 4th patient

The Virus That Breaks the Guardrails: How SARS-CoV-2 Turns the Immune System Against Us - Future of Other Infections? - Increased Cancer Risk? We moved on. The masks came off, the gatherings resumed, and the world whispered, “It’s over.” But SARS-CoV-2 never got the memo. While we returned to normal, the virus stayed busy, etching its damage into our immune systems like graffiti on an abandoned building. The wreckage it leaves isn’t always visible, but it’s there—rewiring how our bodies fight disease, setting the stage for new infections, and quietly sabotaging the systems meant to keep us safe. This isn’t just the story of a virus we think we beat; it’s the story of a virus that’s still working overtime while we look the other way. What happens when the defenses that protected us for generations start to crumble? Spoiler: the virus didn’t move on, and it’s not done with us yet. SARS-CoV-2: The Architect of Immune Chaos The virus doesn’t just waltz through the body; it dismantles the system designed to fight it. Imagine fire alarms that don’t go off and sprinklers that flood the room instead of dousing the flames. • Delayed Interferons, Overzealous Cytokines: SARS-CoV-2 slows down interferons—the immune system’s first line of alarm—while sending cytokines into overdrive, turning inflammation into a wrecking ball. • Exhausted T Cells: With every infection, your T cells—the body’s elite defense force—grow weary. Think of it as sending in soldiers who are running on fumes, no longer sharp enough to tackle the next invader. • Aging the Immune System: Repeated battles with the virus don’t just leave the immune system tired—they age it prematurely, trading resilience for fragility. The Chain Reaction: More Infections, Higher Stakes A weakened immune system doesn’t just mean more colds. It means openings for diseases you thought you’d outgrown or could fend off easily: • Respiratory Viruses Surge: RSV and flu have made a dramatic comeback, not because of “immunity debt” but because SARS-CoV-2 rewrote the immune system’s script. • Bacterial Invaders: Strep A? It’s thriving, thanks to compromised immunity that’s less able to clear bacteria before they take hold. And then there’s the looming specter of H5N1—a virus with a mortality rate that makes SARS-CoV-2 look merciful. In a world where immune systems are already fraying, H5N1 could be the match to the powder keg. The Immune System’s Fragile Dance with Cancer What’s often overlooked in the immune system’s damage report is how it plays referee against cancer. When those referees are sidelined: • Tumors Evade Detection: Cancer cells become experts at blending in, exploiting weakened immune defenses to grow unchecked. • Chronic Inflammation Fuels the Fire: Long COVID’s persistent inflammation doesn’t just linger—it lays the groundwork for tumor survival and growth. • Depleted T Cells, Worsened Outcomes: The very cells designed to kill cancer are the ones SARS-CoV-2 hits hardest. The result? A potential increase in cancer progression and reduced efficacy of treatments. This Isn’t Over: Why We Must Pay Attention The SARS-CoV-2 pandemic isn’t “over.” It’s shape-shifted into a chronic problem, a long-haul disruptor of human health. From immune dysfunction to rising infections to cancer’s opportunistic growth, the echoes of this virus are far from fading. Add to this the threat of future pandemics and it becomes clear: ignoring the immune wreckage of COVID-19 isn’t just shortsighted—it’s reckless. It’s time for vigilance, not just against this virus but against what comes next. Vaccines, therapies to restore immune balance, and public health strategies aren’t just buzzwords—they’re our lifeline in a world where the guardrails are already breaking. Final Thought When we say SARS-CoV-2 “changed the world,” we’re not just talking about masks and Zoom meetings. We’re talking about how it rewired the very thing meant to protect us. And if we don’t take the time to understand and address this silent damage, the next wave—be it from a new virus, cancer, or a resurgence of old foes—will find us woefully unprepared. Sources [1] SARS-CoV-2 and the host-immune response - Frontiers frontiersin.org/journals/immun… [2] COVID-19 and Immune Dysregulation, a Summary and Resource whn.global/covid-19-and-i… [3] The relationship between chronic immune response and ... pmc.ncbi.nlm.nih.gov/articles/PMC98… [4] COVID Impacts: Immune - Memorial Sloan Kettering Library libguides.mskcc.org/CovidImpacts/I… [5] New Research Shows How Cancer Rewires a Key Immune Pathway ... news.weill.cornell.edu/news/2023/08/n… [6] Roles of the immune system in cancer: from tumor initiation to ... pmc.ncbi.nlm.nih.gov/articles/PMC61… [7] COVID-19 disease and immune dysregulation - PMC pmc.ncbi.nlm.nih.gov/articles/PMC95… [8] Cancer and the Immune System: Basic Concepts and Targets for ... pmc.ncbi.nlm.nih.gov/articles/PMC55… [9] The immune system | Canadian Cancer Society cancer.ca/en/cancer-info…

Very weird. The momentum was so high for Harris, record turnouts, but 15M less voted. 🤨 But the swing states split tickets is the strangest part. Who votes for trump, then a blue senator? That does not compute & warrants a recount. This will not go away & will just get louder.

I’m going to delete all my social media accounts today. I will miss everyone here but it’s too painful. I’m going to cocoon with my family while the world explodes.

Andy Kim wins New Jersey Senate race to fill Bob Menendez's old seat ow.ly/sJFm105O0lu

Canadians must hold our 5th Estate accountable for not conveying facts. Frankly, this PM seems to be the only leader who understands & can explain our system vs. @PierrePoilievre, who knows better, but thinks himself a mini-demogogue in Trump’s image. #IStandWithTrudeau2025

It’s war.

Do NOT panic during this first part of the evening. Rural counties report first because they have fewer votes to count -- tends to result in Republicans coming out to early leads. Democratic count tends to come in later in the evening. Keep Kamala and carry on a la.

BREAKING: MAJOR KAMALA HARRIS LEAD IN PENNSYLVANIA Swing state looking good for Harris

when they come for gay marriage, perhaps that is when you’ll realize you’re not as different from the rest of us faggots as you’d hoped. good luck!

Poilievre is the only party leader who refuses to get his security clearance to help protect the country from foreign interference. What is he trying to hide? #cdnpoli

Yes! They will! Millions will sue for a million each plus damages, all because Elon’s lawyer is an idiot! Even for Elon that’s got to hurt.