Gabriel Loeb

Polycystic kidney disease is the most common monogenic cause of kidney failure and affects over 10 million individuals. We've known most PKD is caused by mutations in PKD1 for over 30 years. But how PKD1 prevents disease has remained mysterious, limiting effective therapy.

We are constantly thinking about how to integrate human genetics and better experimental models to identify the mechanisms of human disease @UCSFNephrology, @IHG_at_UCSF, @UCSFDOM . Funding for the next generation of medicine from @NIH. Critiques and feedback welcome!

@BrandesNadav, Fnu Ritu, @yimmieg @ReiterLab @willowcoyote. journals.lww.com/jasn/abstract/…

Polycystic kidney disease is the most common monogenic cause of kidney failure and affects over 10 million individuals. We've known most PKD is caused by mutations in PKD1 for over 30 years. But how PKD1 prevents disease has remained mysterious, limiting effective therapy.

What an awesome session on common variant CKD genetics @ASNKidney #KidneyWk @kidneyomicsamps @LoebLab @LimdiNita

Nice talk by @LoebLab at #KidneyWk! -Approved targeted therapies for monogenic kidney disease -Next generation therapies for genetic disease

Incredible session on Genetics in Kidney Disease #KidneyWeek @ASNKidney Outstanding organization & insightful talks by @Vishal_D_Patel #DanielGale #AliGharavi #GabrielLoeb Grateful for the opportunity to present on Genetics of TMA🙏 Thx #ArleneChapman & #EmilieCornecLeGall

Thank you @ASNKidney! Our lab is very grateful to receive the 2025 Carl W. Gottschalk Research Scholar Grant. Read more about the work here: kidneycure.org/pages/qa.aspx?….

@KSusztak @UCSFNephrology Grateful for the chance to learn from @ksusztak, @parkercwilson, and others @Penn and @PennKidney. So much science to be excited about.

#Whyscience Day51🧠✨A strong finish to our Renal Grand rounds series by a rising star physician scientists ⁦@LoebLab⁩ ⁦@UCSFNephrology⁩ Pushing the frontiers of kidney genomics and single cell omics. The future of nephrology is bright🔆

Are you content with your current chance of developing Alzheimer’s disease?

Steven Pinker: And if you’re still skeptical that universities are worth supporting, consider these questions: Do you think that the number of children who die every year from cancer is just about right?

Exciting paper by @CanaudLab in @jclinicalinvest--doi.org/10.1172/JCI176…. 1) Somatic mutation as a (presumably) very rare cause of FSGS, 2) Targeting the mutated gene PIK3CA is helpful in multiple mouse FSGS models, 3) Activity of podocyte targeted therapy in mouse FSGS.

@MazeInBiotech Very excited to see genetics loci translated into potential kidney therapeutics. SLC6A19 was one of the 138 kidney function genes we nominate in this @NatureGenet paper: rdcu.be/dTwye. How many others would make good targets?

We are pleased to announce that the first participant has been dosed in our Phase 1 clinical trial evaluating MZE782. MZE782 is a potentially first-in-class, oral, small molecule targeting the solute transporter, SLC6A19, and has the potential to address chronic #kidneydisease (CKD) patients. Learn more about the MZE782 program here: businesswire.com/news/home/2024…