Mandl Lab

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Mandl Lab

Mandl Lab

@MandlLab

Immune cell dynamics, migration, and diversity in cells & people @mcgillu. Account run by an exceptional team of trainee-clowns 🧑‍🔬🤡, with critical PI input.

Montréal, Québec Присоединился Haziran 2022
262 Подписки389 Подписчики
Mandl Lab
Mandl Lab@MandlLab·
Huge congratulations to Dr. Connie Shen @peepingcells on delivering an outstanding thesis defense! Our fourth Mandl PhD will soon be leaving the nest, trading cold Montréal for sunny California! ☀️All the best!
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Mandl Lab
Mandl Lab@MandlLab·
Congrats on your travel award to #CSI2024 Sam!! 👇
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Mandl Lab
Mandl Lab@MandlLab·
Interestingly, against a chronic fungal infection 🍄that T cells can't clear, both our model and experiments agreed that this TCR diversity didn't offer any extra protection. So, it seems that these low-binding TCRs are useful for certain chronic battles!
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Mandl Lab
Mandl Lab@MandlLab·
Check out our recent publication in collaboration with the Khadra Lab at @mcgillu - where computational modelling 🖥️ and experimental immunology 🔬join forces to study the role of T cell diversity and antigen binding strength on chronic infection clearance! Find out more 👇
PLOS Biology@PLOSBiology

>90% of #TCR sequence diversity is generated by TdT-mediated nucleotide addition, but what is the benefit of TdT-altered TCRs? @MandlLab show that low-affinity #Tcells generated by TdT are important for curtailing chronic pathogen replication #PLOSBiology plos.io/3HJKOCl

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Mandl Lab ретвитнул
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Melichar Lab
Melichar Lab@MelicharLab·
Excited to share a new preprint from our group! Marie-Ève and team demonstrate an unexpected role for NGFR/CD271 in directly suppressing T cell activity! biorxiv.org/content/10.110…
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Global Immunotalks
Global Immunotalks@globalimmuno·
Please distribute 2024 flyer!
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Mandl Lab
Mandl Lab@MandlLab·
And this work featured on the current issue cover! Amazing collaboration with @JohannesTextor @MelicharLab, and the Westermann team
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Mandl Lab
Mandl Lab@MandlLab·
Wondering what we can learn from the T cell receptor beta sequence about the self-reactivity of a T cell? check out our paper in Cell Systems where we used machine learning to ask this very question👇: cell.com/cell-systems/f…
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Meetings d'Immunologie Montréal
First talk of the evening is by Dr. Mandl who will talk about T cell migration 🧫 La première présentation est par Dre Mandl qui va nous parler de migration cellulaire 🔬
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