Open Genes (Bluesky: open-genes)

Special thanks to trenspotter for submitting the Czech translation and committing a fix. We will include all new fixes for our translations in the new release, along with the new workflow for fetching translations from Localazy

Thanks to our contributors on GitHub: trendspotter Crabchicken

New release! open-genes.com github.com/open-genes/ope… We’re just getting started. More changes are on the way

@ensembl @bluesky Followed you on Bluesky!

You can now find us on @bluesky! 👉@ensembl.bsky.social

bsky.app/profile/open-g… subscribe!

In a couple of days we're going to Bluesky. This account will be still functioning

Open Genes—a new comprehensive database of human genes associated with aging and longevity academic.oup.com/nar/article/52… @OpenGenes @CRafikov

Read more about confidence levels, and why we pay attention to maintaining them in the Open Genes database, in our paper: #434769135" target="_blank" rel="nofollow noopener">academic.oup.com/nar/article/52… 2/2

We added a dataset featuring genes and their confidence levels for download. open-genes.com/download We divided genes into groups with different confidence levels based on the type of data supporting the link between the gene and aging. 1/2

Open Genes now has a new main page. We also added a support chat so you could ask any questions you may have or report a bug

That’s true that reproducibility and questionable quality of controls are vast problems in aging research, both in genetic manipulation experiments and drug testing. In the Open Genes database, we have collected detailed experimental data specifically to be able to analyze the reproducibility of results, the quality of controls, and the most optimal conditions for prolonging life. We tried to take into account everything possible: we collected the controls lifespan, sample size, experimental procedure data, age of therapy initiation, tissue specificity, and everything that can influence the result. The conclusion we made regarding the experiments in mice: for 40 genes there is more than one experiment and no conflicting results (see figures), and there are only 4 experiments with control lifespans above 850 days (SIRT6, GPX4, TRPV1, MTOR). This, of course, does not mean that there are no reliable genetic targets for extending lifespan in mice. However it's a really long road to developing a therapy that works in humans. Read more in our paper: doi.org/10.1093/nar/gk… open-genes.com

@longevity_gene @LBF_org @FirstApproval This is such a great opportunity, thank you!

By today, Longevity Gene has wrapped up all the projects that applied to our labcoat donation auction program. We’ve picked the 3 outstanding projects from the competitive applications. The winning ones are @LBF_org @OpenGenes and @FirstApproval.

We greatly appreciate it! Thank you!