Tim Springer Lab

📣 The Springer Lab is hiring! Advance groundbreaking research at the intersection of integrin signaling, organoid development, and cell surface receptor mechanobiology. timothyspringer.org/news/2025/08/o… #postdocjobs, #academictwitter, #ECRchat, #phdchat

We’ve joined Bluesky! Follow the Springer Lab (@springerlab.bsky.social) for insights into integrin and TGF-β signaling, mechanobiology, organoids and regenerative medicine, and structural biology. #Integrins #StructuralBiology #Biophysics #Organoids #RegenerativeMedicine

A new @nature #cryoEM study on #SARS-CoV-2 details the postfusion spike in a #lipidbilayer, defining the structure of critical membrane-interacting segments that may guide intervention strategies From researchers @ipiproteins @harvardmed & more ⬇️ nature.com/articles/s4158…

Thanks @ipiproteins for sharing our work!

@harvardmed @Stanford @UniofOxford @deboramarks @Harvard @UZH_en @osaka_univ_e Hear a panel on synthetic #antibodies & #OpenScience 👇 🧪Errik Anderson, @AlloyTx 🧪@aledmedwards, @thesgconline & @UofT 🧪Andrew Kruse, @harvardmed 🧪Rob Meijers, IPI #Antibody Platform director 🧪Andreas Plückthun, @UZH_en 🧪Meghan Rego, @Addgene proteininnovation.org/ipisurfacing/?…

Don't forget! Join IPI Surfacing tomorrow at @harvardmed. Networking, discussion, posters & talks👇 🧪Christopher Garcia, @Stanford 🧪Yvonne Jones, @UniofOxford 🧪@deboramarks, @Harvard 🧪Andreas Plückthun, @UZH_en 🧪Junichi Takagi, @osaka_univ_e proteininnovation.org/ipisurfacing/?…

A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8 pubmed.ncbi.nlm.nih.gov/37279271/

Proteins need to breathe: Stabilising conformations in a #malaria #parasite surface protein stops #Plasmodium #sporozoite migration and blocks transmission. Our latest collaboration with @TimSpringerLab out @emboreports. 'Fixing' TRAP 'kills' the parasite. doi.org/10.15252/embr.…

Transforming growth factor (TGFß) is key regulator: immune system, development. There are 3 TGFß's; 1,2,3. Springer @BostonChildrens @HarvardMed use @ATUM_bio constructs. Show TGFß2 is activated by separate integrin. New opportunities for treating fibrosis pnas.org/doi/10.1073/pn…

@ATUM_bio @BostonChildrens @harvardmed pD2529-CAG has become a workhorse in the lab.

🎉 IPI has partnered with @Addgene to provide biomedical researchers worldwide with access to well-validated #antibodies and other reagents, and expertise on how to use them. Look out for our release of a set of #integrin antibodies this fall! Read more: proteininnovation.org/2023/06/addgen…

Recent research by @MyungHyunJO1 @taekjip @XuefengWang11 @timspringerlab & @ipiproteins shows exactly how #integrins harness chemical cues and respond to physical forces. Curious how it works? Read more here 👇 proteininnovation.org/2023/03/integr…

Tim Springer is focused on his existing roster of commitments — running a research laboratory of more than a dozen people @TimSpringerLab, overseeing three NIH grants and sitting on six boards, including @SelectaBio, @MorphicTx, @TectonicTx and @Seismic_Tx endpts.com/with-moderna-w…

@BrianCircleG @LaskerFDN @timothyspringer Hope you are doing well Brian!

@TimSpringerLab @LaskerFDN @timothyspringer 👏 Congrats & Well deserved recognition of their ground-breaking research!!! 👏

Acceptance remarks from @LaskerFDN #LaskerAward winners Richard Hynes, Erkki Ruoslahti, and @timothyspringer for their discoveries concerning #integrins—key mediators of cell-matrix and cell-cell adhesion in physiology and disease: #remarks" target="_blank" rel="nofollow noopener">laskerfoundation.org/winners/integr…

@timothyspringer @LaskerFDN With Richard Hynes & Erkki Ruoslahti, Springer discovered integrins, cell surface proteins that enable cells to interact with their surroundings Today, IPI is creating antibodies that can bind to integrins to accelerate #basicresearch and #drugdiscovery proteininnovation.org/2022/09/integr…

Congratulations Richard O. Hynes, Erkki Ruoslahti, and Timothy A. Springer, 2022 #LaskerAward winners! — “for discoveries concerning the #integrins—key mediators of cell-matrix and cell-cell adhesion in physiology and disease”. @MIT @sbpdiscovery @harvardmed #Lasker2022

2 Boston-area scientists win prestigious Lasker Awards for cell research - discovery of integrins. @TimSpringerLab & Richard Hynes. bostonglobe.com/2022/09/28/nat… via @BostonGlobe

At @BiophysicalSoc's #bps2022 this week, @IPI_Protein co-founder @timothyspringer was awarded the 2022 Founder's Award for his innovations in #immunology, including his work on #integrins. Congratulations, Tim and @TimSpringerLab! 🎉 Story: biophysics.org/news-room/timo…

Interested in growth factor latency? Here a comparative survey of cross-armed, V-armed, and open-armed TGF-β family members from @TimSpringerLab Protection of the prodomain α1-helix correlates with latency in the tr... sciencedirect.com/science/articl…