Tim Welsh

An amazing platform for ultrahigh throughput protein solubility screening! Check the paper: pubs.acs.org/doi/10.1021/ac… Well done Nadia, Tomas, @OellerMarc, @HAusserwoeger, Aviad, @TimWelsh_ , Rungzhang, @DaoyuanQian219, @VendruscoloLab, Sormanni lab and others!

Check out the new DigitISA assay for sensing biomolecular complexes in solution! Well done @GeorgKrainer @KadiLiisSaar @TimWelsh_ @magdaczek @BJacquat and colleagues from Owens, Alberti and Klenerman groups! nature.com/articles/s4146…

Our paper on the digital sensing of protein:aptamer interactions is finally published! One platform shows the ability to sense everything from single proteins up to biomolecular condensates and exosomes, while elucidating many biophysical parameters. Congrats to all authors!

A new method for determining the interaction strengths among compounds that form biomolecular condensates relies on measurements of just one solute in one phase. Read go.aps.org/3Guq7L6 @DaoyuanQian219 @TimWelsh_ @AbellJonny @GeorgKrainer @MichaelsLabETH @KnowlesLabCamb

While antibodies have a remarkable track record in therapeutics, achieving sufficient specificity remains an issue. A Review in @NatRevChem discusses the physicochemistry of non-specificity and outlines future opportunities to improve protein binding. go.nature.com/3O8fK1y

En route to Heidelberg for the #EESPhaseSeparation conference. Only a few more countries to cross before Monday morning! Come find me all week if you want to chat condensates, microfluidics, or bikes!

Check out our preprint discovering DNA-induced LLPS of antibodies based on surface patch driven non-specific interactions: biorxiv.org/content/10.110… Great work by @HAusserwoeger, @GeorgKrainer, @TimWelsh_, Tomas, @SchneiderMatth & Therese. Exciting collaboration with @novonordisk

@KnowlesLabCamb #condensates

When theorists and experimentals collaborate good things happen @DaoyuanQian219. Excited to share our work on the measurement and mechanistic insights of tie-lines in biomolecular phase diagrams. Also, maybe we should stop calling PEG an "inert crowder"? biorxiv.org/content/10.110…

More from @KnowlesLab at #bps2022 in #SanFrancisco. @eaandrzejewska @mus_greta, Alyssa & @TimWelsh_ presenting posters on pre-fibrilliar protein #aggregates and single-molecules studies, oligomer-membrane interactions, microfluidic spray-deposition & #biomolecular condensates.

Super happy to have contributed to this fantastic piece of work investigating the underlying nucleation mechanisms in solutions of phase separating proteins! biorxiv.org/content/10.110…

Excited to share our recent work in @NanoLetters investigating the electrostatic forces that stablize protein condensates! pubs.acs.org/doi/abs/10.102… Thanks to my amazing co-authors @GeorgKrainer, Jorge, @jerelleaj, @rcollepardo and more for their hard work! @KnowlesLabCamb

Pretty stoked to finish 4th overall (3rd male) in the British 24hr Cycling Time Trial National Championships Easily met my main goal of breaking the 55 year old Cambridge University record Taking a day to recover before training loads of new students on microfluidics this week!

@GeorgKrainer You don't want to know 😉 let's just say I'm looking forward to some sleep tonight

@TimWelsh_ Can you let us know the fraction of time slept?

CP4 - St Nicholas church #transengland21

Final #transengland21 activity. @theracingcoll Will be back for more in the future and try to have less mechanicals... strava.app.link/CdvlUQUOEgb

Finish 15:54. Brutal #transengland21

CP5 robin hood's bay #transengland21

CP3 highest Inn in Britain #transengland21