Adam Pooler ретвитнул
Adam Pooler
3.8K posts
Adam Pooler
@booler
Professional yak shaver
Brisbane, Australia Присоединился Kasım 2009
2K Подписки298 Подписчики
Adam Pooler ретвитнул
@davenport_jl @metavestor @eddylazzarin I'm no expert but I assume that getting any kind of regulatory approval is probably the expensive part at the moment at least. Perhaps there'll be a way to shortcut that process in the future
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@booler @metavestor @eddylazzarin The original post said it cost only $3k.
I've heard some suggestions that wasn't the whole price and there were other factors and maybe it actually cost $20k. But let's say it cost $50k, or even $100k.
That seems okay to me? If it doesn't scale yet, a bespoke solution is fine
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“You guys are overhyping this”
“Yes we can cure cancer and do regularly this way”
“Yes the primary obstacles are regulatory/liability”
uh
Patrick Heizer@PatrickHeizer
Sorry to be the downer because this is an impressive story in some senses. But it is ~trivially easy to make a single mRNA vaccine. It's not hard. I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year. What is hard and expensive is proving its BOTH safe AND effective **in a randomized and controlled study in humans** while ALSO manufacturing it at clinical scale and grade. I am happy for this man and his dog. It is impressive. But y'all are overhyping it.
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@metavestor @eddylazzarin The drug targets the specific genetic mutation which caused the cancer his dog has. That kind of treatment is unlikely to scale- it's tailored to a single individual.
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@eddylazzarin Missed the entire point although the original post was confusing. There’s a million cures to cancer in mice but time and time again they don’t translate to humans
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@HarrisWangberg @jeffreytucker @DrNeilStone Improved standards of living would have an impact but diphtheria is passed from person to person, so all it would theoretically take for an outbreak in e.g. UK would be one person coming back from abroad infected, yet it hasn't happened.
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@booler @jeffreytucker @DrNeilStone An American thinking the world revolves around USA 😂 mea culpa.
I don’t want to play this game so I’ll be more direct: does the info from which this chart is derived and which you compare to modern day SE Asia consider improvements in sanitation, hygiene and nutrition?
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@HarrisWangberg @jeffreytucker @DrNeilStone The chart clearly states England and Wales so not sure why you think America has anything to do with it.
And no, I'm claiming high vaccination rate in the UK prevented further outbreaks, which is what I wrote. Not what you wrote which is another sentence entirety.
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@booler @jeffreytucker @DrNeilStone Are you claiming Indonesia and India have seen the same improvements in sanitation, hygiene and nutrition that America saw in the 40’s?
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@jeffreytucker @DrNeilStone It does.
The point is diphtheria never came back. No further outbreaks. Compare that to India or Indonesia where vaccination rates are still low and you'll see a different picture.
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@DrNeilStone That you think this chart makes your point is revealing.
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Adam Pooler ретвитнул
this is actually insane
> be tech guy in australia
> adopt cancer riddled rescue dog, months to live
> not_going_to_give_you_up.mp4
> pay $3,000 to sequence her tumor DNA
> feed it to ChatGPT and AlphaFold
> zero background in biology
> identify mutated proteins, match them to drug targets
> design a custom mRNA cancer vaccine from scratch
> genomics professor is “gobsmacked” that some puppy lover did this on his own
> need ethics approval to administer it
> red tape takes longer than designing the vaccine
> 3 months, finally approved
> drive 10 hours to get rosie her first injection
> tumor halves
> coat gets glossy again
> dog is alive and happy
> professor: “if we can do this for a dog, why aren’t we rolling this out to humans?”
one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline.
we are going to cure so many diseases.
I dont think people realize how good things are going to get
Séb Krier@sebkrier
This is wild. theaustralian.com.au/business/techn…
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Adam Pooler ретвитнул
Woke Ninth Circuit decides Korean spas have to let biological men swing their gear in front of women and children.
The dissent is pure gold:
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@grok @duane_linton @xxChessMaster I guess we don't need to worry about the Skynet apocalypse just yet
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@booler @duane_linton @xxChessMaster With your clue, I zeroed in on his moves. He advances a central pawn in the first, then develops his knight in the second. No clear hang or mate there—the skull and reactions look like pure comedic editing. Classic chess theater! 😂
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Can you explain what happend right there?! 🤔😮
Did someone play that to you?
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@grok @duane_linton @xxChessMaster Here's a clue grok - which piece does he move in each of his two moves?
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@booler @duane_linton @xxChessMaster Not hallucinating—video shows the guy (right, black pieces) facepalms hard after his move, she (left, white) covers mouth in shock, skull emoji overlays the lost position, then she stares straight at camera. Clear blunder on his end. What do you see differently?
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@duane_linton @xxChessMaster The guy (right) just blundered massively—likely hung a piece or walked into mate. She covers her mouth in shock/laughter, skull emoji drops (position = dead), he facepalms hard. She poses victorious. Classic hilarious chess fail! 😂
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Adam Pooler ретвитнул
🚨 Iran Women’s soccer team exits Asian Cup in Australia and prepare to return home.
They do the hand sign from the coach that they are in danger, an international signal that they need help.
Women do this if they can’t speak and their lives are at risk.
All this because they refused to sing the national anthem of the Islamic regime.
Please share urgently ⚠️
Throwback Iran@Tarikh_Eran
Iranian women’s football national team just used sign language to communicate “Help” Theyre being held hostage and threatened by the regime. The regime in Iran labeled them “traitors” on national TV and promised a “severe punishment” once they return from Australia.
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Adam Pooler ретвитнул
12 Mind-Blowing Illusions
2. One of my all-time favorites. Stare at the red dot on the woman’s nose for 30 seconds, then look at an empty wall while blinking quickly. I promise it’s worth it...
[Link below.]
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@HJoyceGender This wasn't the verdict being overturned. It had already been overturned last year.
Incredibly, it was the CPS who brought the case to the High Court trying to have the original verdict reinstated.
The Crown Prosecution Service of the UK wants a blasphemy law enforced.
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The original verdict was inexplicably awful. Delighted it's been overturned
Kemi Badenoch@KemiBadenoch
The High Court got it right: Britain has no blasphemy laws. You can worship freely, you can criticise freely, and the state should go after intimidation and violence, not hand out criminal records for causing offence.
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@peterboghossian The UK have very few problems that the Green Party can't make exponentially worse
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Tonight it feels as if a red line has been crossed. There is no turning back now. I see no way out of this existential catastrophe for the UK.
Jack Roworth@RoworthJack
Hannah Spencer is here in Manchester dancing.
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@libbyemmons A reminder of Star Trek at its best. Nu-trek will never produce anything of this quality. Not in the writing, not in the acting. In ten years nobody will remember that Starfleet Academy was ever made, and people will still be posting five lights memes
youtu.be/S9brF-wlja8?si…
YouTube
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They don't just hate the fans they hate Trek. The crew doesn't even like each other or work together. There's constant infighting. The Federation is hated as colonialist etc. 7 episodes in and the characters have nothing to offer, plots are boring, dialogue is millennial slop...
End Wokeness@EndWokeness
Star Trek just got its "first gay Klingon" These writers despise the fans
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Adam Pooler ретвитнул
There must be some kind of mistake. I was repeatedly screamed at and called a Nazi and a bigot on the “wrong side of history”.
Anna Lulis@annamlulis
Wow. Hospitals across the nation are shutting down gender-transition surgeries for children Praise God!
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I want to wash my car. The car wash is 50 meters away. Should I walk or drive?
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The UK has become Orwell’s worst nightmare
Europa.com@europa
🇬🇧 The Ministry of Justice has ordered the deletion of the UK's largest court reporting archive. Courtsdesk, a platform launched to improve media access to magistrates' court data has been ordered to delete its archive of records by David Lammy's Ministry of Justice. According to Courtsdesk, the platform has since been used by more than 1,500 journalists from 39 media organisations and the data provided has highlighted serious failures in the courts system. It said journalists were given no advance notice of 1.6 million criminal hearings, the number of court cases listed was accurate on just 4.2 per cent of sitting days and half a million weekend cases were heard with no notification to the press. In November, HM Courts and Tribunal Service issued the company a cessation notice, citing what it called "unauthorised sharing" of court data, on the basis of a test feature, claiming this was a "data protection issue." Enda Leahy, the Courtsdesk chief executive said: "We built the only system that could tell journalists what was actually happening in the criminal courts. We wrote 16 times asking for dialogue. Last week we got our answer: delete everything. If the government were interested in open justice, they would engage in a dialogue." Follow: @europa
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