Tony Cook nag-retweet
Tony Cook
2.4K posts

Tony Cook
@BTonyCook
Technology, Science, Business & other interesting stuff. Tweets are my own and are not the views of my employer.
Melbourne, Australia Sumali Aralık 2010
1K Sinusundan155 Mga Tagasunod
Tony Cook nag-retweet
Tony Cook nag-retweet
Tony Cook nag-retweet
Tony Cook nag-retweet

As a medical school professor, this may be the most unexpected finding in metabolic medicine right now.
A massive new study shows GLP-1 drugs like semaglutide don't just help with weight and blood sugar. They slash depression risk by 44% and anxiety disorders by 38%.
Hospitalizations dropped by 42%. Substance use-related sick leave fell by 47%.
Even suicidal tendencies declined.
These are staggering numbers that suggest metabolic health and mental health are far more connected than we ever taught in medical school.
This isn't just a weight loss drug producing side benefits. GLP-1 receptors are found throughout the brain. Preclinical research shows they directly affect mood, motivation, and reward circuits -- effects independent of weight loss.
It's more evidence for what I write about in "Lies I Taught in Medical School": the metabolic dysfunction driving obesity is the same dysfunction driving depression, anxiety, and addiction.
Full breakdown coming on the Health Longevity Secrets podcast.
Source: newsweek.com/semaglutide-gl…
#GLP1 #MentalHealth #MetabolicHealth #Longevity #HealthLongevitySecrets

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My Google Nest hub has been randomly playing Spotify lately. Turns out that @theblindfactory has a new ad where the woman says “hey Google play my favourite song”
Advertisers need to be careful with this.
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Tony Cook nag-retweet

"A pure gold exposure company."
Gerard Bond of @OceanaGold celebrate the company's IPO on NYSE Live! $OGC
The full interview: youtu.be/b8tW332LJrs

YouTube
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Tony Cook nag-retweet

#TheMasters
Bernhard Langer displaying the driver he used to win his second Green Jacket in 1993
It was the last time a persimmon driver was used by the winning player
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Sadly, this is NOT available in Australia (and possibly some European countries) This is going deny money to @gravitaur as there is plenty of interest in the doco.
What is happening @PrimeVideoAUNZ @PrimeVideo
That UFO Podcast@ufouapam
It’s out #Lazar
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Tony Cook nag-retweet
Tony Cook nag-retweet

Ozempic activates a 'repair mode' in cartilage cells, boosting joint thickness by 17% and potentially reducing the need for invasive surgeries.
For years, experts assumed that the joint pain relief seen with Ozempic was mainly due to weight loss. A landmark 2026 study has challenged that view. Researchers from the Shenzhen Institutes of Advanced Technology discovered that semaglutide—the active ingredient in Ozempic—acts directly on cartilage cells (chondrocytes) to promote regeneration.
By reprogramming the cells' energy metabolism (shifting from inefficient glycolysis toward more efficient oxidative phosphorylation via the GLP-1R-AMPK-PFKFB3 pathway), the drug helps trigger a restorative process that rebuilds the protective cartilage cushioning in joints—tissue long thought to be irreplaceable once lost.
The results are striking. In a small pilot clinical study, advanced MRI scans showed an average 17% increase in cartilage thickness after six months of treatment, along with signs of new cartilage growth in weight-bearing areas. Patients also experienced reduced pain and improved joint function.
This breakthrough points to a new way of treating osteoarthritis: not just managing symptoms, but addressing the underlying structural damage. While larger trials are still needed, semaglutide is emerging as a promising option that could help millions of people avoid or delay joint replacement surgeries and restore mobility through direct cellular repair—independent of its well-known weight-loss effects.
[Qin, H., Yu, J., Yu, H., et al. (2026). Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism. Cell Metabolism, 38(3), 582–597.e6. DOI: 10.1016/j.cmet.2026.01.008]

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Tony Cook nag-retweet

Jevons paradox is happening in real time. Companies, especially outside of tech, are realizing that they can now afford to take on software projects that they wouldn’t have been able to tackle before because now AI lets them do so.
We’re going to start to use software for all new things in the economy because it’s incrementally cheaper to produce. Marketing teams at big companies will have engineers helping to automate workflows. Engineers in life sciences and healthcare will automate research. Small businesses will hire engineers for the first to build better digital experiences.
And as long as AI agents still require a human who understands what to prompt, how to review when an agent goes off the rails, how it guide back, how to maintain the system that was built, how to fix the ongoing bugs, and more, we will still have humans managing these agents.
This is why all the advice you get of not going into engineering is wrong. The world is going to increasingly be made up of software, and the people that understand it best will be in a strong economic position. This will happen in other roles as well where output goes up and demand increases.
Lenny Rachitsky@lennysan
Engineering job openings are at the highest levels we’ve seen in over 3 years There are over 67,000 (!!!) eng openings at tech companies globally right now, with 26,000 just in the U.S. We don’t know if there would have been more open roles if not for AI or if AI is actually leading to more open roles, but since the start of this year, the increase in open eng roles is accelerating even more.
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Tony Cook nag-retweet
Dear Aunty.. Some suggested programming while you're on strike today:
The Goodies
Monkey
Dr Who
To The Manor Born
Yes Minister
Mother & Son
The Late Show
Frontline
Parkinson
Countdown
#LongTimeViewer
#ABC #ABCStrike

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Tony Cook nag-retweet

What a lovely surprise this morning! ☀️Independent detections of similar transients in European plate archives — exactly the kind of cross-validation this field needs. So it’s not just Palomar anymore.
The study was carried out by a retired NASA scientist.
This is how a signal begins to emerge from the noise.
arxiv.org/pdf/2603.20407

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Tony Cook nag-retweet

Helium is the only element that escapes Earth’s atmosphere permanently. Once released, it rises through the troposphere, passes the stratosphere, and leaves the planet. It cannot be manufactured. It cannot be synthesised at industrial scale. It accumulates over billions of years in the same geological reservoirs as natural gas. And one third of the world’s supply just went offline because Iran hit the facility that extracts it.
Qatar produced roughly 63 million cubic metres of helium in 2025, accounting for 30 to 36 percent of global supply from a total of approximately 190 million cubic metres. QatarEnergy’s three large helium purification plants at Ras Laffan form the world’s biggest helium production base. When LNG production stopped after Iranian drone strikes on March 2 and the subsequent missile damage on March 19, helium extraction stopped automatically because helium is recovered during natural gas liquefaction. You cannot produce helium without producing LNG. The byproduct dies with the primary product.
Spot helium prices have roughly doubled since the crisis began. Industry consultants warn that prolonged disruption could push contract prices toward $2,000 per thousand cubic feet. A major industrial gas supplier has already begun assessing customers a helium surcharge. Phil Kornbluth, the most cited helium market consultant, stated the assessment directly: the world cannot compensate for the loss of a third of its helium supply.
South Korea imports 64.7 percent of its helium from Qatar. SK Hynix and Samsung operate high-volume fabs producing the DRAM and high-bandwidth memory that power every AI accelerator, every data centre GPU, and every cloud computing cluster on Earth. Helium cools silicon wafers during fabrication. It serves as a carrier gas in deposition and etching tools. It enables leak detection in vacuum systems. Modern extreme ultraviolet lithography requires helium-cooled environments for precise temperature control. Without helium, the fabrication process degrades or stops.
SK Hynix and Samsung hold two to three months of helium inventory. Two to three months is not a buffer. It is a countdown. If Ras Laffan remains offline beyond that window, South Korean memory production faces rationing. TSMC in Taiwan is somewhat more diversified but still uses Qatar-linked supply chains. The entire AI hardware supply chain, from HBM3E memory stacks to advanced logic chips, sits inside helium-dependent ecosystems.
Beyond semiconductors, helium cools the superconducting magnets in more than 14,000 MRI machines operating worldwide. It pressurises rocket fuel tanks and purges propulsion systems in aerospace. CERN’s Large Hadron Collider depends on helium cryogenic systems. There is no substitute for helium in any of these applications at industrial scale.
The United States and Qatar together account for more than 70 percent of global production. The US federal helium reserve and private suppliers offer partial relief, but global prices and spot availability are still governed by Qatar’s market share. Japan’s Iwatani has drawn on US reserves. Canada and the Rockies are seeing renewed investor interest. None of this replaces 63 million cubic metres in weeks.
The war hit uranium first. Then oil. Then nitrogen. Then water. Then plastic. Then medicine. Then sulfur. Now helium. Eight layers. Each one deeper. Each one closer to the infrastructure that sustains modern civilisation. The chip that processes your data, the magnet that scans your body, and the rocket that launches your satellite all depend on an atom that leaves the planet when you lose it.
open.substack.com/pub/shanakaans…

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Tony Cook nag-retweet

This fun interactive tool allows you to draw circles anywhere in the world to see how many people are around you. A 3km circle around my home in Melbourne shows that I have almost 84,000 people nearby I can annoy in person with my maps! Play with the tool here: tomforth.co.uk/circlepopulati…

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