I Alexander SC

Benchmarking shotgun metagenomics dlvr.it/TSCQJn #MicroSky

Benchmarking of shotgun sequencing depth reveals the potential and limitations of shallow metagenomics and strain-level analysis dlvr.it/TS8TVG #MicroSky

Cognition without brains? Learning and memory in microorganisms dlvr.it/TS5Nwb

Bacteria are full of diverse molecular tricks. This Science article reports an interesting one that is being misrepresented by news coverage, including the coverage in Science. The study describes an enzyme complex that synthesizes alternating dinucleotide repeat DNA as part of an immune response. Protein templating DNA is a cool observation, even if the sequence is only a repeating dinucleotide. The headline-grabbing takeaway is the mechanism of the Drt3b subunit. While its partner, Drt3a, uses a canonical RNA template (reverse transcription), Drt3b synthesizes the complementary strand in the absence of a nucleic acid template. Instead, it uses specific amino acid residues (a glutamate and an arginine) to stabilize and "select" the incoming dNTPs. It is tempting to view this as a radical shift in our understanding of information transfer, a "protein-templated" genetic sequence. However, we should be cautious with the "paradigm shift" narrative. Why this isn't "rewriting" the Genetic Code: Despite claims in the news coverage, this finding does not represent a new form of hereditary information transfer. This is not a protein "reading" itself to create a complex message; rather, it is a highly specialized structural constraint. The protein is essentially a "stuttering" machine, physically keyed to produce a simple, repetitive sequence. The "information" is hard-coded into the protein's fold to perform a single, specific defensive task, rather than acting as a general-purpose template for diverse genetic messages. The Parallel to tmRNA: This observation is not entirely unprecedented when we look at how bacteria handle biochemical "dead ends." It reminds me of transfer-messenger RNA (tmRNA). In trans-translation, when a ribosome stalls on a broken mRNA, the tmRNA molecule steps in to provide both the tRNA component and a short mRNA "tag" to rescue the ribosome: - The "Non-Standard" Template: Much like tmRNA provides an external sequence to fix a stalled process, the DRT3 ncRNA and the Drt3b protein provide "internal" instructions to create DNA where no genomic template exists. - Specialized Rescue: Both mechanisms are niche "emergency" responses, one for proteostasis (tmRNA) and one for viral defense (DRT3). In the end, this discovery doesn't replace our understanding of the genetic code; it expands the "toolbox" of how cells can synthesize polynucleotides when the standard rules don't apply. It is a beautiful reminder that in the microbial world, if a chemical shortcut is possible, evolution has likely found it.

Terminal Genome Viewer github.com/zeqianli/tgv Another one that is around for a while: ASCIIGenome github.com/dariober/ASCII…

Micro-scale spatial metagenomics opens a new era in microbiome ecology dlvr.it/TRrM4y

Startups are providing tantalizing glimpses of AI-assisted antibody discovery and claiming game-changing potential, even as new models remain hidden and industry awaits full disclosure and benchmarking nature.com/articles/s4158… [🔓read free with login]

Generalist biological artificial intelligence in modeling the language of life go.nature.com/3NdkqaE

[RNA-Seq Data Analysis Software] We have released RNA-Seq Data Analysis Software. With our software, you won't need to outsource or rely on collaborators. You can start analyzing data yourself right away, without the need for high-spec computers or knowledge of Linux commands.

Nature research paper: Capturing dynamic phage–pathogen coevolution by clinical surveillance go.nature.com/4saG9iC

Enjoy! iies.unam.mx/libros/Manual-…

Porfa compartan lo más que puedan, la visibilidad hace toda la diferencia 🙏🏻…

New online! Epistasis and co-adaptation in bacterial genome evolution dlvr.it/TRFVPp

@Juancamilo9110 @Lycantocles Entonces es demasiada apegada a los juegos jaja

@Lycantocles Podrá pegarse al guión (lo desconozco porque no lo juego), pero la actuación es un completa mierda. Parece serie de pre adolescentes. No pude ni terminar el primer capítulo, por lo patética que se veía.

Ya lo dije, pero lo repito todas las veces que sean necesarias: Fallout es la mejor serie basada en un videojuego de la historia. vidaextra.com/analisis/mejor…

@AmargadoT @templo_del_geek Justo así se siente el juego no sé de qué hablas

@templo_del_geek 9, la única cosa que no me gusta tanto es que el tono de tanta comedia/gore quita impacto hacia la muerte o sensación de peligro sobre los secundarios. Cómo que se vuelve rutinario que mueran de la forma más horrible posible y sigan como si nada.

¿Qué nota le pones a la segunda temporada de #FalloutSeason2? 👀 ¿Es mejor que la primera temporada? 🤔 #FalloutOnPrime #falloutseason2spoilers

@ticketelhamster @zaynmalik Pero que ya no se vea intrépido comiendo botanas mexicanas

🚨México y otros países de LATAM no podían faltar en las nuevas fechas de ZAYN! ⚠️Pronto más detalles… ¡Feliz cumpleaños @zaynmalik! 🔥✨ #Zayn #tickethamster #viral

@LorenaR79399 @CAPUFE Hola. Como están , hay algún avance?

@CAPUFE Son las 06:00 am y @CAPUFE seguimos varados en las cumbres de maltrata y desde las 10:08 pm abrieron paso ¿ Entonces que pasa, porque no avanzamos?

🔴 CIERRE DE CIRCULACIÓN🔴 Autopista Acatzingo - Cd. Mendoza, km 227, dirección Acatzingo. Cierre a la circulación por atención de choque por alcance múltiple entre tracto camiones y automóviles. En la zona se registra #neblina. Toma tus precauciones. Consulta la ubicación aquí: maps.app.goo.gl/XmbPS8QhmENBis…

@hostofaghostt @CAPUFE @GN_Carreteras Como están? Mi familia quedó varada y no hemos recibido actualización. Han avanzado algo?

No pueden tener a tanta gente varada en la carretera por más de 12 hrs en frío y sin comida, hagan algoooo!!! @CAPUFE @GN_Carreteras AYUDA en las cumbres de maltrata!!!!

@Thousand_O @Lore1719 @maqueda_viviana @CAPUFE Espero que todo bien a ambos. Hay actualización ? Mi familia quedó barada y no creo que se les apagó sus celulares

@Lore1719 @maqueda_viviana @CAPUFE Ok muchas gracias esperemos por acá comienze la circulación

Congrats to Broad Clinical Labs, Roche and Boston Children's Hospital for making a Guinness record for fastest genome sequencing! They were able to sequence and analyse the whole genome in <4 hrs, surpassing the previous benchmark of 5 hrs and 2 mins. A NEJM paper reports application of this rapid workflow in seven NICU patients that returns genetic diagnosis in < 8 hrs. Amazing! News: broadclinicallabs.org/broad-clinical… NEJM paper: nejm.org/doi/full/10.10…