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A new ImmunologyExplained video looking at the common research and diagnostic technique of ELISA, used mainly to quantify antigen in a biological sample:
patreon.com/posts/elisa-77…
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InCytometry - Graham Bottley
33.6K posts
InCytometry - Graham Bottley
@InCytometry
Providing training in Flow Cytometry for thousands of researchers since 2011. Immunologist and Flow Cytometrist for 25 years. ImmunologyExplained Patreon
Wensleydale, UK Sumali Kasım 2011
2.2K Sinusundan3K Mga Tagasunod
@NickAnderegg That is irrelevant to your claim that it impacts immunity against other pathogens
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@InCytometry So? Does that make SARS-CoV-2 not be the most common virus with respiratory transmission in circulation right now?
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Here's one that refers to T cell exhaustion IN THE TITLE.
"However, the marked exhaustion pattern remains over time. This dysregulation could constitute a risk factor for reinfection and the development of other pathologies."
Complain to THEM, not me.
pubmed.ncbi.nlm.nih.gov/37240647/
InCytometry - Graham Bottley@InCytometry
@NickAnderegg No. You clearly don't understand the literature. No literature anywhere shows general T cell exhaustion.
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@NickAnderegg I decided to correct your incorrect statement
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@InCytometry The mechanism is different, but the risk is arguably HIGHER with SARS2 given the risk of reinfection. You decided to be a pedant and assume that two completely separate statements were written in the same train of thought. Did you forget about that? x.com/NickAnderegg/s…
Nick #RespiratorsFilterPathogens😷 Anderegg@NickAnderegg
See, this is the problem with "um acktchually-ing". I totally see why you think this! And I was ambiguous! - In the thread, I refer to the specific type of T cell exhaustion you are referring to! - In response to a question, I *did* then describe GENERAL T cell exhaustion.
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@InCytometry T cell exhaustion in SARS2 and HIV are different, I wouldn't disagree with that one bit.
With HIV, the compromised immune system is a risk for many common infections.
But with SARS2, the compromised immune system is a risk risk for the MOST COMMON infection
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@NickAnderegg I pointed out a clarification to your post, so yes, I am helping. I have not said that there is no impact on immunity. ALL viruses have some form of immune evasion or suppression.
Do you think you are helping by misleading people?
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@InCytometry Do you think you are helping by jumping into every thread to argue about semantics without engaging with the message being communicated?
You are ignoring all of the non-experts who use people like you to claim there is no immune impact WHATSOEVER
x.com/InCytometry/st…
InCytometry - Graham Bottley@InCytometry
@NickAnderegg I spend most of my time dealing with antivaxers, virus deniers, conspiracy theorists and cranks. You are none of those. However, scientific accuracy is absolutely vital, and there is a common claim that the virus causes general immune damage. It doesn't
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@NickAnderegg And that is important when your posts are read by non-scientists.
If they interpret your posts as meaning that the SC2 virus can damage immunity against other pathogens, then you are misleading them.
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@NickAnderegg I spend most of my time dealing with antivaxers, virus deniers, conspiracy theorists and cranks.
You are none of those.
However, scientific accuracy is absolutely vital, and there is a common claim that the virus causes general immune damage. It doesn't
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See, this is the problem with "um acktchually-ing". I totally see why you think this! And I was ambiguous!
- In the thread, I refer to the specific type of T cell exhaustion you are referring to!
- In response to a question, I *did* then describe GENERAL T cell exhaustion.
InCytometry - Graham Bottley@InCytometry
@NickAnderegg You said that it increased susceptibility to other infections and cancer. So yes, you did.
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@NickAnderegg I would agree that the virus can exhaust T cells against that infection specifically, yes.
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@InCytometry Would you agree with the statement that SARS-CoV-2 can exhaust T cells in a way that is *particularly* concerning when the virus is continuing to circulate at a high level?
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InCytometry - Graham Bottley nag-retweet
I did wonder if using a picture of a bacteriophage would upset some virus deniers & (rolls eyes) yes it did…
A virus which infects bacteria is a virus—I also love their utterly funky appearance!
Here’s a picture of a difference virus, one which affects mammals, can you name it?
Rosewind@Rosewind2007
Yeah—it’s worth saying this very clearly: Viruses exist We have abundant proof of their existence If you don’t understand that proof, this looks to be willful ignorance and very much a you problem Viruses are very much a real thing Image shows structural model
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@NickAnderegg But potentially yes, very much so.
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@NickAnderegg That depends on the time between infections, the severity of infection, the infectious dose the second time and whether there was viral persistence, which in itself is a major cause of T cell exhaustion
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@NickAnderegg You said that it increased susceptibility to other infections and cancer.
So yes, you did.
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And for the record, at no point have I said there's "general" T cell exhaustion. Why are you acting like exhaustion of the T cells responsible for fighting a ubiquitous, immune-evasive virus is not potentially lethal on its own?
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@NickAnderegg See what you are doing is reading a paper without understanding the methodology or the immunological context, and then you are extrapolating that to a downstream effect that doesn't occur.
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@NickAnderegg Oh my word.
Right.
There IS T cell exhaustion, but only in some clonal lineages. Not in all T cells.
That is a very, very important distinction.
And the papers you yourself link to show that. Have you not even read them?
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Literally take the issue up with the papers that use the term "T cell exhaustion" if it's actually being used incorrectly. I'm just an interpreter who is connecting the pieces.
You're still insisting that this interpretation is wrong WITHOUT A SINGLE REFERENCE PROVIDED
Arion Games Co.@ArionGames
@NickAnderegg No, it specifically shows T cell exhaustion IN SOME T CELLS ONLY. Specifics are very important in immunology.
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@NickAnderegg No. You clearly don't understand the literature.
No literature anywhere shows general T cell exhaustion.
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"All those papers that specifically describes 'T cell exhaustion'? Yeah, well, my anonymous twitter account says that I actually know more than all of them."
See, I know I don't know what I'm talking about, which is why I closely stick to the literature, which disagrees with you
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So what you're saying is that you're a pedant fixated on a specific definition of T cell exhaustion? Have you considered that terms evolve?
Why is your definition correct, but every other experienced immunologist or virologist using that term IN THE LITERATURE this way is wrong?
Arion Games Co.@ArionGames
@NickAnderegg Sigh. I am a viral immunologist who has worked on viral immune evasion for thirty years, have been working on the immune response to SC2 and have a current project investigating immune exhaustion. I know what I am talking about. And none of your links show what you claim.
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InCytometry - Graham Bottley nag-retweet
If you are interested in a Marie Sklodowska-Curie Fellowship application with our lab in tumour virology, please contact me. Example publications from the group nature.com/articles/s4138… and pubmed.ncbi.nlm.nih.gov/33303976/). #HPV #cancer
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@FreeManOnEarth9 @smthngnope @m1sfitm9gn_t @Jhon50996854042 Explain then how HLA-restriction maps geographically to viral epitopes then.
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At Cyto2024. I haven't been to a Cyto Conference for a few years, so it is nice to catch up with lots of other cytometrists!
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@smthngnope @Jhon50996854042 @FreeManOnEarth9 Amazing, isn't it.
I have made over half a million £ from that hobby so far, doing something I really enjoy, and with a worldwide appreciative audience.
They somehow see it as a negative thing.
Says a huge amount about their own outlook on life.
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@Jhon50996854042 @FreeManOnEarth9 @InCytometry yup, he's the guy making bucks doing two jobs he loves, whilst you all sit around talking shite on here about him, letting him live in your heads, rent free.
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